Bliley PM
Subject: European Exposure/Misclassification Study - Questions on Design
Abstract
Provides agenda and outlines potential objectives and research questions for planning meeting on Center for Indoor Air Research (CIAR) study of environmental tobacco smoke (ETS) in Europe. Indicates CIAR study design produced in response to recently completed International Agency for Research on Cancer (IARC) ETS epidemiologic study to address "smoking misclassification" and other issues with IARC study design and methodology. Regards ETS markers as " RSP, solanesol, nicotine, 3-ethenyl pyridine, UVPM?, FPM?), as well as indoor and outdoor air pollutants (e.g. VOCs)". Indicates "Philip Morris USA Confidential" (attachments missing).
Fields
- Company
- Philip Morris Cos., Inc.
- Type
- Fax
- Memorandum
- Author
- Patskan, G.
- Author (Organization)
- Philip Morris U.S.A.
- Recipient
- Andrade, Anthony J. "Tony" (PM Associate General Counsel, Switzerland)Associate General Counsel for Philip Morris. Worked for Shook, Hardy and Bacon. Vice President, PM Worldwide Regulatory Affairs, 1994. Responsible for management and direction of ETS focused department. Reported to Steven Parrish, Senior VP of PM External Affairs.
- Carchman, R.
- McAlpin, L.
- Walk, R (Research Fellow)
- Reif, H
- Copied
- Goodheart, J.
- Logue, M.
- Pottorff, M.
- Purcell, C.
- Winokur, M.
- Named Person
- McAlpin, L.
- Named Organization
- Center for Indoor Air Research
- CIAR
- International Agency for Research on Cancer (IARC) (WHO cancer research arm)International Agency for Research on Cancer - The cancer research arm of the WHO. Conducted a multi-center epidemiology study on ETS, initiated in 1988, data collection completed in 1994 and results were published in 1998
- International Agency for Research on Cancer
- Keyword
- 3-ethynylpyridine
- Air pollution
- Air sampling equipment
- Analysis
- Controls
- Cotinine
- DOC CODE: P0622
- Environmental tobacco smoke
- ETS
- Exposure factors
- Indoor air pollution
- Protocols
- RSP
- Solanesol
- UVPM
- VOCs
- Volatile organic compounds
- Subject
- Adults
- epidemiology
- Government agencies
- Human subjects
- Industry front groups
- industry response
- industry sponsored research
- International level
- nicotine
- Nonsmokers
- Research studies
- secondhand smoke
- Surveys
- Tobacco industry scientists
- tobacco industry structure
- Additives
Document Images
I~o, 7545
USA.
To:
From:
Subject:
Distribution
George Patskan
PHILIP MORRIS U.S.k.
INTEROFFICE CORRESPONDENCE
Richmond, Virginia
European Exposure/Misclassificafion Study - Questions on Design
Date: Ju~y 26, 1994
Prior t~ tho initiation of an ETS exposur~ study in Europe cer'~n questions will ne~ to
b~ answered. While this will bca CLAR, study it is important for the sci~ntis~s at Philip Morris m
discuss the ux:hnical issues surrounding this study. The primary qu~tiorf~ssuc will b~ to clearly
d~fme the objectives of the studics, kseping in mind how the dat~ can b~ utilize~ A preliminary
set of obj~,ctivcs is attached. Once the objectives have been clearly defined other re2smd technical
issues should be discussed. Lists of some of the questions are also attached. I am sugges~ng that
we me~t m discuss thee issues for a day during the wc~k of August 8, 1994. Please contact
Lorc~n McA1pin to arrange a time for ~is me, ctingo
Proposed Agenda:
i. Review the design of the IARC epidemiology study
2. Define clear and specific obj~tives for the European smoking misctassification and exposure
studies
3. Outline experimental protocols
4. Address specific questions/technical issues (e.g., analytes, numbers of subjects, sampling
equipment)
At~chment
A. Andrade
R. Caxchman
L, McAlpin
H. Reif
R. Walk
cc: J. Goodheart
M. Logue.
M. Pottorff.
C, Purcell
M, Winokar
DOC CODE: P0622
1994 4: [£PM .~to, 7545 £, 3
PhiLip Morri~ USA
Confi~entlat
OBJECTIVES OF STUDIES
1. Gather data rep~sentative of the subjects and controls in the IAIZC study (i.e. adult,
nonsmolmrs from the general population)
:2. A~ses~ the misclassification of smokers ss nonsmokers by cotinine measurements and
ques~onnalres
3. During a 24 hr period, assess the level of exposures to ETS marJmr~ (P, SP, solanesol,
nicotine, 3-ethenyl pyridine, UVPM ?., FPM ?), a~ well as indoor and outdoor air pollutants (e.g.
vocs)
QUI~STIONS
• Which countries and cities should be included?
• What ~ampling methods should be used?
• What analyses should be made?
• Are them sub-objectives which influence the study design?
• When are the results required?
This list ~s by no means exhaustive, it merely presents some exampk:s.
DOC CODE: P0622
