Tobacco Documents Online

Mr. Paul b-~ntth H. Wakeham Minute~ of Visit to High Tot July 25, 1967 In the company of the following persons I visited High Tor Foundation lsboratories on Oak Tree Road In Palisades, New York on Thursday, July 20, 1967: H. T. Austern, Covington ~t Bttrling A1 Forsyth, attorney for U. S. Tobacco Company Word B. Bennett, of U.S.Tobacco Company William Bates, Liggett ~t Myers Tobacco Company Robert Grtfflth, Brown & Willtarnson Tobacco Company Murray Senkus, R. J. Reynolds Tobacco Company Alex Spears, P. Lorillard Company Louis Beck of Chemical Research and Development Corporation Mr. Tanenbaum, his lawyer ?/e were met by Dr. Perry Hudson who first discussed the general problem of testing cigarets for biological effects. He stated he had investigated various methods before adopting the subcutaneous injection method. In this procedure the animal was injected with rather large amounts of tobacco smoke condensate for a period of 8-10 day~ after which the animals were watched for physiological effects. In the Initial experiments the quantity of condensate injected was too large re~ulting in a necrosis, that is a sloughing off of the skin with the release of the aecumtflated condensate. This process is in effect a foreign body reaction on the part of the animal. By the use of , ~smaller quantities of condensate Dr. Hudson and ht.~ associate, Dr. McDuffy (Mrs. Perry Hudson) claimed to have demonstrated an 87/o incidence of flbro- carcinomas in a sample of 100 mice treated with the extract of untreated tobacco smoke. No mali,.,maant neoplasms were produced from the "Chemoaor' treated tobacco. Dr. Hudson is now anticipating criticism of his technique tests. ,....: and conse~luently is beginning a serious of long-term skin painting _ " 1000033521 ' Considerable discussion was had with ,Dr. Vlscelll, the senior chemist in the laboratory, regarding the method of preparin~ the smoke condensate extract. It was quite clear from the description of thta preparation that Dr. Vlscelll was removing approximately 75)~ of the condensate in order to obtain a de- nicottntT-~l fraction suitable for Injection. This fact alone would mitigate against any tmeful conclusions regarding whole smoke to be obt atned from their biological experiments.

Mr. Pa,:-~mi~h -2- July High Tor Foundation is described as an exl~.riment in the learning of biological science. Excel~ for ~e ~rev senior st~ mem~rs mentton~ ~e. ~e rest ~ the ~rsonnel s~m to ~ high s~l and ~er~uate co~e s~n~ ~o In smo~ come.ate ~e~atton, tn the chemic~ work, md in ~e biologtc~ ~ments. Un~r ~e circ~atan~ one Is not aur~ts~ at the lack G In conversation w[~ Mr, Louis ~ck d~In~ the ~turn rida to New York, Mr, ~ck was s~rongly c~vinc~ that they have now ~d~uately demons[rat~ biol~cel eff~t for ~e "Ch~o$ol" treat~ ct~a a~ that ~etr reacts co~tttute pr~f of s '"s~ clg~et." H~ d~s n~ a~ee wl~ ~. ~y Huron with res~ct to ~e lack ~ Im~ance of ~a)p~en~. ~. Hudson several times In hl~ denied the ~alue ~ r~uclng ~a)p~ene since h~ did n~ feel th~ bloI~ic~ eff~ts were du# to "chemical carcln~enes~." He s~m~ to ~ retreating ~om ~. earlier ~ition ~at '"Ch~osol's" major ~n~lt Is In ~e r~uctton ~ ~nz(a)p~ne In smoke, ~ob~ly b~ause.he now dou~s the vadiltty ~ his analysis. Mr. ~k 1~ still quite s~ong tn his ~lld ~at the ~nz(a)p~ene content of "Chemoaol" treat~ tobacco smoke Is r~ue~ and Is lm~ant as an i~lcator o~ a "s~er elg~et." He places ~t reliance on ~e ~a~ ~at the slides ~e~ fr~ s~ti~ d ~e dlseas~ antma~ were ~amln~ by ~. Auerbach, ~. Arth~ P~dy .Stot~ of the Collie of ~lclana and S~g~ Col~Ia University, and by s~eone from the Natlon~ l~titute ~ Health. When I ~int~ out to him ~e pi~ls and bla~es which might arise In w~k e~t~ out by ~ple who have such cl~e ~sonal involvem~t tn the ex~rlment ~ a whole, and that the entire work sh~Id ~ re~t~ by ~ I~e~ent tnvestt~tor, Mr. ~ek sta~d that ~ey could not. watt forever wl~ this finding while "2~ other testa were ~lng ~ne." He is cle~ly impatient to get on with ~e exploitation ~ "Chemosol."