Bliley Lorillard
Annual Report to Shook, Hardy and Bacon February 1980 to January 1981
Abstract
Encloses Annual Report of Atmospheric Health Sciences, Inc. (AHS). Reports activities for the first year were "scientifically informative, financially successful, but disappointing, poor in advancing atmospheric health research." Summarizes smoking and health projects performed for Shook, Hardy & Bacon (SHB) as well as other projects executed for other groups. Notes that all AHS activities deal with "the evaluation of the effects of chemicals and substances in the atmosphere on humans, healthy and otherwise." Lists reports submitted to SHB. Includes financial report and daily log. Duplicates Bates 2062774413.
Fields
- Type
- REPORT
- Letter
- Author
- Aviado, Domingo M., M.D. (CTR Consultant; Special Projects Recipient)Dr. Aviado was a University of Pennsylvania professor and did work for tobacco companies. Dr. Aviado did secret dog inhalation studies in 1970s which were apparently covered up. Dogs were inhaling. No research papers were ever done, apparently (B.C. 7/7/94).
- Recipient
- Shinn, William W. (TI Communications; Shook, Hardy, CTR Attorney)TI Communications Committee and was also a lawyer for CTR. William W. Shinn worked for Shook, Hardy & Bacon.
- Sirridge, Patrick M. (Attorney, Shook, Hardy and Bacon)
- Recipient (Organization)
- Shook, Hardy and Bacon
- Named Person
- White
- Froeb
- Schmidt, C.
- Aranow
- Repace, J. L.
- Cox, A.
- Named Organization
- Shook, Hardy and Bacon
- SHB
- Atmospheric Health Sciences
- AHS
- New England Journal of Medicine
- University of Pennsylvania Medical School
- FTC
- Federal Trade Commision
- EPA
- Environmental Protection Agency
- Science magazine
- College of Medicine and Dentistry of New Jersey
- Columbia College of Physicians and Surgeons
- Johns Hopkins University
- Health Effects Institute
- Harvard University
- University of Pennsylvania
- Medical College of Pennsylvania
- Stanford University
- University of California San Francisco
- University of Southern California
- University of Rio
- University of the Philippines
- University of Athens
- University of Cairo
- Clean Air Scientific Advisory Board Committee
- Webster and Sheffield
- Kirkland and Ellis
- American Petroleum Institute
- Kirschtein, Kirschtein, Ottinger and Cobrin
- Adams, Escrofa and Geral
- Dow Chemical
- Lowell, Muccifori, Adler, Ravaschiero and Amabile
- JRB Associates
- Office of Toxic Substances of EPA
- Office of Drinking Water of EPA
- Consumer Products Safety Commission
- Mobil Oil Corporation
- Johnson and Johnson Baby Products Company
- MacMillan Co.
- Wiley
- Springer-Verlag
- NIEHS Publications Office
- Region
- United States
- Philppines
- Argentina
- Egypt
- Brazil
- Greece
- Keyword
- Aldehydes
- Alcohols
- Surgeon General's Report
- Critques
- Pollutants
- Polycyclics
- Benzene
- Herbices
- Pesticides
- Chlorinated Solvents
- Urea-formaldehyde
- 1,2 dichloropropane
- Pyridine
- Hexachlorobutadiene
- Alky epoxides
- Antimony metal
- Toluene glycidol
- Clean Water Act
- Trichloroethylene
- Tetrachloroethylene
- Vinyl chloride
- Methyl chloroform
- Dichloroethane
- Carbon tetrachloride
- Carcinogens
- CO
- Carbon monoxide
- Corticosteroids
- Cotinine
- Expenses
- smoking and health controversy
- Thesaurus Term
- Tobacco industry law firm
- tobacco use
- government agency
- industry sponsored research
- disease
- lung cancer
- nicotine
- non-smoker
- low-yield cigarette
- additive
Document Images
pHON'~201o879.3111
DOWn, Go M. AVLtDO, M.D.
• ~0 K~ET~O~M
aHORT wrrr~t N. J. 07078
January 20, 1981
Mr. William W. Shinn
Mr. Patrick M Sirridge
Shook, Hardy and Bacon
20th Floor Mercantile Bank Tower
1101 Walnut
Kansas City, MO 64106
Dear Bill and Pat:
I am enclosing my .Annual Report, with separate portions for scientific
and financial. In each of the two parts, I differentiated the Smoking and
Health Projects from Other Projects (court cases, public policy, etc. ).
I am prepared to revise the Report if you contend to distribute copies
to your clients. I intend to be in Kansas City on Monday morning,
January 26, as planned.
Yours very truly,
Domingo M. Aviado, M. D.
P.S. The revised report on aldehydes, and the new report on alcohols
(Tobacco Additives) are also enclosed.
Enclosure s:
.,Annual Report
F~nancial Report
Aldehyde s
Alcohols ~.~
DMA/ag
Europeon Office:
c/o Innolech International
38, rue de la Division Leclerc
941 ] 7 Arcueil Cedex
France
Phone (331} 664-18-60
Telex: 204- 017F
ATMOSPHERIC HEALTH SCIENCES, INC.
P. O. Box 307, Short Hills, New Jersey 07078
Phone (201) 379-3141
ANNUAL REPORT TO SHOOK, HARDY AND BACON
Febuary 1980 to January 1981
Asion Office:
c/o Mabuhay D.-vclopmen! Co.
63 Tamarind Road
Makati, Manila
Philippines
• Phone {6~2) 88-04-94
Telex : 7425330
Atmospheric Health Sciences, Inc. (AHS)was incorporated
in the State of New Jersey on Febuary 11, 1980. Its major client is
Shook, Hardy and Bacon (SHB) which has agreed to support three-quarters
of the consulting activities of AHS. The remaining quarter has been
supported by governmental agencies and private industry. The activities
during the initial year can be summarized as scientifically informative,
financially successful, but disappointingb, poor in advancing atmospheric
health research. This report summarizes the projects performed for
SHB as well as other groups, to illustrate that coincidentaLly, the
activities of AHS has one central theme: the evaluation of the effects of
chemicals and substances in the atmosphere on humans, healthy and
otherwise.
SHB Projects on Smoking and Health
The year started with an assignment to review the 1980 Surgeon
General's Report and is concluding with a review of the 1981 Report.
Between the two projects, there were opport~,-%ites to explore the role
of cigarette smoking in groups of individuals with diseases of the cardio-
pulmonary system. Thus pneurnoconiosis, byssinosis, my"asthenia and
chronic obstructive lung disease were explored in detail The subject
of involuntary or passive smoking, of special interest to the consulting
scientist of AHS, was repeatedly explored including an appearance in a
public hearing and submission of material to Editors.
Page - Z -
SHB Project I: Critique of 1980 Surgeon General's Report.
A~ter the release of the report entilded The Health Consequences
of Smoking for Women, the literature files were examined and approx/mately
a thousand articles were separated as relevant to the subject. Critiques
on five chapters were prepared: (i) patterns of cigarette smoking;
(2) mortality; (3) morbidity; (4) cardiovascular diseases; and
(5) nonneoplastic bronchopulmonar¥ diseases. The critique on the
chapter on cancer in the 1980 Report was being prepared together with
that on cancer in the 1979 Report, when other timely subjects demanded
a postponement of completion of the critique. This project is not complete;
however, the literature on the uncompleted chapters have been set aside
for future use for: cancer, pregnancy and infant health, peptic ulcer
disease, interaction of smoking with drugs and food constituents,
psychosocial and behavioral aspects of smoking in women.
SHB Project 2: On~oin~ review of literature on Smokin~ and Health.
Approximatel~, 2000 articles were received to add to the files
that exceed 30,000. The files are currently being reorganized because
the topics of primary interest to the tobacco industry and to governmental
agencies were not anticipated when the comprehensive fi/es were started
in 1972. Half-day a week was spent to read articles as they were received
and to select articles that were relevant to the ongoing projects.
SHB Project 3: Review ol literature on Lun~ Cancer.
Since the principal investigator has not previously reviewed
the literature on cancer, a special effort was made to complete the files
on lung cancer. The files which include over 3000 articles are complete
in all aspects of lung cancer - etiology, pathogenesis, diagnosis, therapy
and experimental carcinogenesis. Governmental publications are also
included in the files, as they relate to carcinogens in the drinking water,
in food, in the atmosphere and in the occupational setting. The files are
proving to be useful in the other SHB projects, such as asbestosis, in-
voluntary smoking, silicosis and coal pneumoconsiosis.
Page - 3-
SHB Project 4: Bronchopulmonary Effects on Nonsmokers.
The appearance of White and Froebs' articles in the New
England Journal of Medicine in March 1980 led this consultant to review
several aspects of the article. A five-part critique was submitted
discussing the technology and interpretation of results relating to small
airway function (6). A/though letters were written to two publications,
only the Editor of the New England Journal of Medicine accepted the
submission for publication (7).
SHB Project 5: Pharmacolog)r of Nicotine.
The files on nicotine as a pharmacologic agent include 1500
articles, of which a hundred were selected for preparing a manuscript
for delivery at the University of Pennsylvania Medical School. The
paper was presented on May 28, 1980 as the Carl 1~. Schrnidt Honorary
Lecture (8) and is being rewritten for publication in a Pharmacology or
Medical Journal.
SHB Project 6: Coal Workers Pneumoconiosis.
A review of the literature indicated that experts question
any significant role of cigarette smoking in contributing to the respiratory
impairment of pneurneconsiosis of coal workers (9).
St-IB Project 7: Carbon Monoxide.
The techniques for carbon monoxide analysis proposed by the
FTC have been reviewed but no written report was prepared summarizing
the 300 articles relating to the subject. The availability of a manuscript
on an EPA-spons~red project written by Aranow raised questions on the
validity of excercise testing to evaluate cardiac effects of very low levels
of carbon monoxide. This consultant and his colleague visited clinics
• _l~at have experts in cardiac function evaluation and some of them are
willing to conduct a study to answer questions raised by Ar~now's most
recent unpublished study and earlier publications.
Page - 4 -
SHB Project 8: Indoor Pollution.
The appearance of a §cience article b7 Repace on the presence
of unreasonable levels of particulates indoors from smoking led to a
submission of a letter to the Editor.
SHB Project 9: New Jersey Assembly Public Hearing.
This consultant testified in a July Z4 public hearing, questioning
the health reasons of the proposed law, prohibiting smoking in public
places (10).
SHB Project 10: Corticosteroid Secretion.
The literature on the hypothetical relationships of corticosteroid
secretion, phychosocial stress and susceptibility to malignancy of smokers
was reviewed (11).
SHB Project 11: Cotinine as Nicotine Metabolite.
The measurement of urinary excretion of cotinine was discussed
as an investigative tool to estimate nicotine absorption from the
respiratory tract (IZ).
SHB Project 12: Byssinosis.
The literature on the interaction between cotton dust and
cigarette smoke was reviewed (13). Subsequent to the completion of the
review, additional articles appeared in the current literature that will
require a more comprehensive examination of the files which now total
300 articles on byssinosis.
SHB project 13: Myasthenia Gravis.
This consultant's appearance at the New Jersey State Assembly's
public hearing led to a request from the Chairman to explain the unusual
reaction of myasthenic patients to cigarette smoke in public places. A
supplementary statement on the subject was submitted to the Chairman
(14).
SHB Project 14: Low Yield Cigarettes.
This consultant was requested to comment on the literature on
the health effects of low yield cigarettes. Approximately 500 articles on
Page - 5 -
epidemiologic studies and animal toxicology have been collected but the
material has not been summarized.
SHB Project 15: Tobacco Flavoring Additives.
This consultant was requested to initiate a literature retrival
system on the toxicity of tobacco flavoring additives. From the two
publications listing the additives, he has proceeded to summarize the
information on aldehydes (151 and alcohols (161 and has collected the
information on other organic compounds, inorganic compounds and
plant constituents. Additional summaries for additional groups of
flavorants are planned for 198 I.
SHB Project 16: 1981 Surgeon General's Report.
As this Annual Report was being completed, the 1981 Surgeon
General's Report was released, entitled The Changing Cigarette. Since
the literature on the subject has been collected, this consultant will
proceed to write a critique and will devote the remainder of the first-
year contract to this subject.
Additional SHB Projects _.
There was ample opportunity for this consultant to assist in
several assignments, most of which are related to smoking-associated
diseases and one on pesticides. They were as follows:
(a) .Carcinogenesis and Tuberculos~ (L. H. Price in Louisiana).
Peripheral Arterial Disease and Alkaloidal constituents of
tobacc0"and medicinal plants (Argentina).
(c) Health Effects of Public Smoking in a Far Eastern country
(Philippine s ).
(d) Silicosis and Sandblasting (M. Young)~
(e) Combustion of Silica for Self-extinguishing cigarettes
(California).
(f) Interaction of cigarette smoke and asbestos particles
(asbe stosis ).
(g)
(i)
Page -~6 -
Me dical and Psychos ocial Aspects of Smoking-As aociate d
Burns (C. E. Bias in California).
Soil persistence of pesticides (Aldrin/Dieldrin).
Health Effects of Public Smoking in a Mid-Eastern country
(Egypt).
Unive r sit~,- Related Activities
This consultant has remained as Adjunct Professor of Pharma-
cology at the College of Medicine and Dentistry of New Jersey (Newark).
However, he has explored the possibility of an academic appointment at
Columbia College of Physicians and Surgeons (New York) and at the
5ohns Hopkins University (Baltimore)but these plans have not been
finalized, since details of research f~ding have not been settled. Early
in 1981, Mr. Archibald.Co~ the President of the Health Effects Institute
at Harvard University has expressed his intention of having this consultant
participate in research activities of the newly-formul~tted research
institute that will be distributing research funds.
For the record, this consultant has also visited the following
medical centers: University of Pennsylvania, Medical College of
Pennsylvania, Stanford University, University of California-San Francisco,
University of Southern California, University of Rio, University of the
Philippines, University of Athens and University of Cairo.
Consultantships with Governmental Agenc)r and
Private Industry.
Atmospheric Health Sciences, Inc. received .~ contract~from
several groups that occupied one-quarter of its activities:
A. Environmental Protection Agency.
As a member/consultant of the Clean Air Scientific Advisory
Board Committee, the following documents were received: criteria
Page - 7 -
pollutants, polycyclics, hazardous pollutants and proposed Clean Air
Amendments. This consultant spent an unusuall7 excessive amount of
time disappropr~ate to the income derived from the Agency. Furthermore,
requests for assistance from other governmental agencies were not
honored because of limited time.
B. Law Firms :
i. Webster and Sheffield (New York) representing a tobacco firm's
case on a beautician who developed lung cancer.
Kirkland and El/is (Washington) representing the American
Petroleum Institute on proposed governmental regulations
on benzene.
3. Kirschtein, Kirschstein, Ottinger and Cobrin (New York)
representing a generic firm on possible patent infringement
of a drug.
Adams, Escrofa and Gerel (Washington) on behalf of Dow
Chemical on workmen compensation cases involving chlorinated
s olve nt s.
Lowell, IVIuccifori, Adler, Ravaschiero and A/nabile (Toms
River) representing two New 5erse¥ firms on urea-formaldehyde
poi s oning.
Contract Firm: JIRB Associates (McLean, VA)
Review of health effect documents for the Of/ice of Toxic
Substances of EPA, on priority chemicals under Section 4 of
Toxic ~ubstance Control Act: i~ 2 dicldoropropane; pyrid~e;
hexachlorobutadiene; alk¥1 epoxides; antimony metal and
salts; methlrlethyl ketone, meth¥1isobutyl ketone, toluene
glycidol.
Review of drinking water criter£a documents for the Office of
Drinking Water of EPA, under the Clean Water Act: trichloro-
ethylene, tetrachloroethylene, vinyl chloride, methyl chloroform,
dicldoroethane, and carbon tetrachloride.
Page - 8 -
3. Review of chemicals for the Consumer Products Safety
Commission: formaldehyde.
D. Mobil Oil Corporation.
Review of health effects of herbicides, pesticides, paint
constituents and plastic resins.
E. Johnson and Johnson Baby Products Company.
Prepare position papers on development of new drugs for treatment
of newborn, infants and children, with special reference to prevention and
management of congenital diseases.
F. Publishers.
1. MacMillan Co. : to assist two nurses and a physician in writing
a textbook of pharmacology for nursing and allied professions.
Wiley: to write a chapter for Patty's Industrial Toxicology.
3. Springer-Ver!a~: to write a chapter on sympathomimetics for
treatment of bronchial asthma.
4. NIGHS Publications Office: to write a chapter on cardiotoxicity
of commercial solvents.
G. European Office.
Established a European Office in Paris to assist European
companies in registration of drugs. A French firm organized a meeting
on arteriopathy in Rio de Janeiro last April. Trip to Greece and E~rpt
was also arranged by the European office. An Italian firm has approached
AI-IS to assist in introducing a new drug in the United States.
H. Far Ea'stern Office.
Established Far Eastern Office in Manila to assist in organization
of international meetings. American firms have requested A/IS to assist
in the registration of pesticides and also to distribute clinical testing kits
to identify drug addicts.
Page - 9 -
Reports Submitted to 5~nook, Hardy and Bacon:
Critique of 1980 Surgeon General's Report: Patterns of Smoking
Among Women: 13 pages with I0 references, March 8, 1980.
Critique of 1980 Surgeon General's Report: Overall Mortality
Among Women: 17 pages with 22 references, March 26, 1980.
Critique of 1980 Surgeon General's Report: Cigarette Smoking
and Morbidity Among Women, 6 pages with II references, March
26, 1980.
Critique of 1980 Surgeon General's Report: Smoking and Cardio-
vascular Disease in Women: 18 pages with 57 references, ?
Critique of 1980 Surgeon General's Report: Smoking and non-
neoplastic bronchopulmonary disease in women,
Small Airway Resistance, 31 pages with 58 references, April
2, 4, 9 and 11, 1980.
o
Small Airway Dy.sfunction in Passive Smokers (Letter to Editor)
New England Journal of Medicine 303:393, August 14, 1980.
Pharmacology of Nicotine: 16 pages, May 28, 1980.
Coal Workers Pneumoconiosis and Cigarette Smoking: 7 pages .
with Z0 references, June 24, 1980.
10.
Testimony of Doming. M. Aviado: New Jersey State Assembly,
16 pages with 25 references, July 24, 1980.
II.
12.
Cigarette smoking, corticosteroid secretion, psych.physical
stress and susceptibility to neoplasm: a critique of their hypo-
thetical relationship: 12 pages with 25 references, July 28, 1980.
Cotinine metabolism: ?
13.
14.
Cigarette smoking and cotton dust bysi,~nosis.
references, August 20, 1980.
4 pages with 13
Supplementary statement of myasthenia gravis: 7 pages with
7 references and enclosures, September 24, 1980.
