Bliley Lorillard
[CTR Research Proposals]
Abstract
Summarizes tobacco industry research projects designed to mitigate the relationship between smoking and disease. Offers projects intended to refute "misleading statements regarding cigarette smoking, commonly apprearing in anti-smoking propaganda." Includes several population-based data collection projects. Presents geographic studies designed to establish differences in lung cancer distribution that fail to correspond to differences in smoking habits. Outlines project description, purpose, term, cross reference, and "recommended auspices."
Fields
- Type
- REPORT
- Summary
- Author (Organization)
- CTR
- Named Person
- Berkheiser
- Saiger
- Hammond
- Kreyberg
- Ochsner
- Gillliam, Dr.
- Rosenblatt
- Diehl, Dr.
- Wynder
- Auerbach
- Langston
- Passey
- Wolfe, Dr.
- Russek
- Herman, D.
- Perrone
- Poche
- Leuchtenberger
- Saffioti
- Radford
- Hockett
- Yerushalmy
- Hester
- Kinsey
- McNiven
- Harris
- Dmochowski
- Trentin
- Huebner
- Toolin
- Stewart, S.
- Named Organization
- CTR
- Surgeon General's Advisory Committee
- Senate
- SAB
- Region
- Hawaii
- Japan
- Yugoslavia
- Poland
- Ireland
- Sweden
- Puerto Rico
- USA
- Mexico
- Africa
- Keyword
- Ten City Survey
- Classification 132-163
- Amish Menonites
- Mormans
- nuns
- Seventh Day Adventist
- Framingham
- Kasparian
- Polonium
- Nitrosamines
- Sprunt
- Harris inhalation index
- I-2
- II-25
- A (II-1,3,4)
- A (II-2)
- A (II-5,44)
- II-10
- A (II-8,9,10,22,23,32,33)
- A (II-14,15,16)
- Thesaurus Term
- Industry sponsored research
- Cancer
- Disease
- Tobacco use
- Tobacco industry structure
- Lung cancer
- Cigarette ingredient
- Cardiovascular disease
- Smoke
- Data analysis
- Animal research
- Respiratory disease
- Pollution
Document Images
A (II-14, 15~ 16)
Pro~ect:
A'nalyze the accuracy o,~ vital stati~stics
reportin~ primary and secondary lun~ cancers.
Purpose:
To demonstrate ~hat many cancers of the lun~
reported uudor Cl~assific~ion IS2-I~3 of
vital statistics arose in other sizes and
were~seconda~y in the lung. Further @urpose
' to refute Dr. DiehI's letter to the Sen=re
which in substance stated tha~ practically
all of the cancers so reported were primary.
Term: Short.
Reconuzended Auspi,ces :
Outside, Ad Hoc.
A (II.2S, 30, 31)
II - 28. Pro~ect:
Purpose:
A study of areas that constitute pockets
of high lung cnncor incidence without rel.stion
to smokin~ habits (compnrinz New Orleans, Ten
Cit[ Sux-vcy, E1 Paso, New Yo~k City, Pittsburgh
and perhaps ~exlcan vlomen and Dr. Palmer's
pro~ect in. the southern part of Africa).
To illustrate that there are areas which
have a hIch incidence of lunz cancer not
cor{espondinz to smokin~ hsbits.
Term: Long, with possible short-term results.
Recommended Auspices: (h:tsilde.
30.
P~o~ect:
A study of areas which, constitute pockets
of low lunE cancer incidence not correspondin~
to smokins habits. (Consider survey of desert
and mountain state areas, most of which were
omitted by H~mmond in his s~udy.)
Purpose: To demonstrate th=t cancer incidence is no¢
related to ~okin~ hzblts.
Term: Lon~, %vith possible sho~t-term results.
Recommended Auspices: Outside.
II
II -Sl. Pro~ec~:
A study o~ the incidence of lunG: cancer and:
other pertinent diseases in non-smoklng popu-
lations (compare ~mish, ~enonltes, nuns and!
Mormons; consider a re-do of the Seventh Day
Adventist studies done by Wynder~ as to which
question has been raised.)
Purpose: To establish the incidence of lung cancer in
~on-smoking populRtions,
Term: Lon~.
Recommended Auspices: Outside.
A
(II-47; IV-l,9; %'-2)
II
Pro~ect: Collect emphysema cases among non-smokers
and amonc yovnc people.
Cross-Reference: IV
Purpose:, To demon~tTate that both non-smokers nnd-
yo~n~ people who have smoked briefly
have emphys~ma~ thus dilutln@ any asso~lation
between smelting and emphysema.
Term: Long~ with possible shore-term results.
Recommended Auspices: Outside.
z. project:
Collect cases of epidermoid lung cancer in non-
smokers.: Prepare a slide demons~ration.
Cross-Reference:
and ~
Purpose:
To demonstrate that epidermold lung cancers do
occur in non-smokers and thus refute assertions
that these cancers only occur in smokers.
Term: Short.
Recommended Auspices:
Ad HOC.
A
IV- 9. project:
Collect autopsy data showing so-called "pre-
cancerous" changes in non-smokers occurring
as aresult of systemic causes, e.g., substances
such. as cortico-sterolds or some vlta~in deficiency,
etc,
Cross-Reference: III and V
Purpose:
To demonstrate that so-called "pro-cancerous"
changes occur from systemic conditions brought
about by medicines in co,men use, as well as
other systemic factors, and not necessarily
through direct contact with inhalants.
Term:
Recommended AuSpices:
Long-term, with possible short-term results,
Outside.
V-- 2. Project_:
Collect and prepare visual demonstrations
of sl, ides showing Auerbach-type:changes in
the lungs of a large number of non-smokers.
Cross Reference: IV
Purpose: To demonstrate the so-call:ed pre-cancerous
changes are found in the lungs of non-smokers.
V
Ter~: Short..
Reconnnended Auspices:
Ou ts id o.
Pro~ ect:
Purpose:.
Arrange for a vew of the literature with
regard to emohysema, particularly to document
that the cau.~3 or causes of emphysema are
To document how little is known about the
cause or causes of emphysema.,
Term,: Short o
"~ecommendedAusp~ccs:
Outside.
A (III-2)
[(
III
llll - 2,
CollectS11 o~ th~unpub,lished negative
animal experiments ~,th tobacco (including
skinpain,ting nnd ir~hal,ation) o
Cross-Referenc~:i VI
Purpose:
To bring togo~her the negative results with
respect to efforts to produce the pertinent
diseases in animals with, tobacco.
Term: Short.
Recommended, Auspices::
.~d Koc.
A (III-14)
Ill - 14. Project:
Studies to determine whether there are cancers
"without so-called "pre-cancerous" changes and
to demonstrate that there are so-called "pre-
cancerous" ch-~nges which do not progress to
cancer. Collection of slides showing these.
A slide and history demon.stra~ion of
"pre-cancer" in ~eas ot~r than
(e.g. uterine cervix, oral cavity,
skin, e~c.), which ~ve recessed ~ re~in~
the s~e £~oughout a ~r£od of ye~s
She~ diagnosis~
~oss-Re~erence: V
~ose: To demons£ra~e tha~ the so-called "pre-
cancerous" changes referred $o by Auerbach
and o~rs ~e no~ in fact prec~sors
C~cer.
Te~: ~ng, with possible shor$-tem results.
Reco~ended A~pices: Outs£de.
I'II -- IT,
A (III-17; IV-5)
Pro;~ect.:
Clinical studies to be conducted by Lan~ston
and others to show that duration and amount
smoking have no relation to the age of peak
incidence of lung cancer,
Cross-Reference:
Purpose:
To fortify Passey's observations that the
amount and duration of smoking do not affect
the time when lung cancer appears and thus tO
Cast doubt on any causal hypothesis.
Term: Long, wlth. possible short-term results.
Recommended Auspices: Outside and Ad Hoo (Langston study
now inproEress),
Project:
Conduct a study to compare the age of peak
incidence of lung cancer in d~fferent geo-
graphical areas. Endeavor to tie this in-
formation to the peak age of starting smoking,
if posslble, and also to the average age at
death in the particul'ar, area.
Cross-Reference: II
• " Purpose:
To determine whether the peak age of lung
~ancer incidence is affected by variables
and, £~,so,, to demonstrate wha~ variables
affec~ it. Also to refute Kreyberg"s theory
of a 40-year l'atent period.
Terg: Short.
Recommended Auspi.ce~:
Outside.
III
~II - 26, Pro~ect:i
Purpose:
Documentation of the discrepant data in the
Alb~ny and ~T~mingham studies concerning
Ca~d~ovascul~r disease (expansion of ob-
servations o~ Dr. ~o~ffe.) Correlate Albany
and Framln~h=a findln~s with Russek findings that
there is mo~,~ hear~ disease inno~-smokers th~n
in ex-smokerso
To demonstrate the inadequacy of exlstlnE
ep,ldemiological data indicating smoking as a
cause.of hen~ disease.
Term: Short.
Recommended Auspices:
Ou~slde.
