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Bliley Lorillard

[Regarding Kissen's Proposed CTR Special Project and Battelle's Dog Inhalation Study]

Date: 21 Apr 1967
Length: 2 pages
00552848-00552849
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Abstract

Transmits confidential memorandum in longhand regarding "Kissen's work", indicating Hockett's endorsement for support from Council for Tobacco Research (CTR). Transmits Battelle Memorial Institute's proposal for "an inhalation study for dogs". Modifies study objectives because "[i]t is not intended, nor expected that there is anything about the test that would permit complete extrapolation of results on dogs to human beings". Requests feedback (attachments missing).

Fields

Rank
1
Company
Lorillard
Type
LETTER
Author
Hardy, D.R.
Author (Organization)
Shook, Hardy & Bacon (Tobacco Industry law firm)
Tobacco Industry law firm based in Kansas City, KS.
Recipient
Grant, P.R.
Recipient (Organization)
Lorillard Tobacco Co. (American cigarette manufacturer)
American cigarette manufacturer; makes Kent, MaxSatin, Newport, Old Gold, Style, and True cigarettes.
Copied
Russell, John C. (LOR Attorney, Perkins Daniels & McCormack, later in-house)
J. C. Russell was employed by Lorillard, Inc. and served as Counsel from 1965 to 1969. He was also on the Committee of Counsel. (Source: LOI/LOC Summary of Officer & Directors - LOI/LTC Liability Notebook)
Named Person
Hockett, Robert Casad, Ph.D. (CTR Scientific Director)
Scientific Director of the Council for Tobacco Research from 1972-1974 (WSJ 2/11/93; Allman complaint). Bio-Research Institute BRI conducted a study for the CTR. When Syrian hamsters were exposed to smoke twice a day for 59 to 80 weeks, 40% of those of a cancer-susceptible strain and 4% of a resistant strain developed malignant tumors (WSJ 2/11/93). Before publishing the study in 1974, BRI's founder, Frederic Homberger, sent a manuscript to Robert Hockett, then scientific director of the CTR. Dr. Homberger says he had to do so because halfway through his study, the CTR had changed it from a grant to a contract so they could control publication. They were quite open about that (WSJ 2/11/94. Soon thereafter, Hockett and CTR lawyer Edwin Jacob went to Dr. Homburger's summer house in Maine. Hockett and Jacob did not want BRI to call anything cancer, they wanted it to be "pseudo-epitheliomatous hyperplasis," a euphemism for lesions preceding cancer (WSJ 2/11/93). Dr. Homberger said no, this is not right, it is cancer. Jacob told Dr. Homberger that BRI would never get a penny more if the paper was published without the changes. At the last minute, Dr. Homberger changed the final proofs to read "microinvasive" cancer, a microscopic malignancy. Nevertheless, BRI was never funded by the CTR again (WSJ 2/11/96) Hochett made a statement, as scientific director of the CTR circa February 1972 that neither tobacco and health research in general, nor that of the Council for Tobacco Research has established that tobacco use or cigarette smoking in particular is a major health hazard (Allman complaint, pp. 41-42). Robert C. Hockett was Scientific Director, Vice President and Research Director of CTR. See Bio-Research Institute, TTLA Almanac - Names. (N.M.'s CTR Who's Who)
Kissen, Dr.
Anderson, Eugene (ATC Board of Directors from 1980 to 1983)
Defense, Attorney with Chadbourne & Parke Representing ATC.
Spears, Alexander White, III (LOR President & CEO)
Associated with CTR, used as an expert in the Mississippi case.
Auerbach, Oscar, M.D. (Research Scientist, VA Hospital, E. Orange, NJ)
Named Organization
*Council for Tobacco Research-- U.S.A. Inc. CTR (Formerly Tobacco Industry Research Committee (TIRC))
Created and funded by the tobacco industry to award grants to study of the link between smoking and disease. Part of a four decade effort to cast doubt on the links between smoking and disease.
Battelle Memorial Institute
Keyword
Inhalation (Smoke inhalation)
Thesaurus Term
research activity
Respiratory (bronchodilation) (Effects)
animal model
animal smoke inhalation
expenditure

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Page 1: 00552848
Philip Grant: Esq. Vi~ce -Presiden~ ~hd- Ge-ne~a~ -Counsel P. Lorilla-rd Co~6an~- ' - - 2uu East 42nd ~- - ~ - - -- S,..~ree ,. - - " _ New York, New York~uu~ ~ ~z T - . - _ Dear Phil : - _ - _. in accord~ce-w~th our telephone conversatZon, i-am enclosing herewith for your infor~atior~ a_ con~ide.nti~l memo- randum in- longhan~ which Dr. H~kett sent me and which your info~matio~ bnly~ togethe~ with copies of ~sev~xa~-a~ticLes and editorials respec%in~ Dr~-Kis~en's work. As ~ shared on the telephone, ~he proposal is that as a special project C.T.R. would suppo;ct Dr. Kissen for a two yea£ period to the extent of $56,000 per year, with a proviso that Dr. Kissen would be noti~ fled six m~nth~ before expiration as to whether or not C.T.R. planned to continue the support beyond the two year period. The une, er~ining and notes on the various articles are mine ~d are worth your conside~-ation because they show the imporh~nce of the area which Kissen is investigating. Thi~ mat.- ter se~ms worthv;hile and is reconh~ended st~-ongly bzDr. i am also enclosing a copy o~ a iettcr dated February 24 from Battelle Memori31 Institute m~king a pr=posal to Dr. Hockett on an inhalation study for do~s You %<J_!l note that I have brac%[- eted the t~vo paragr6;phs in the center of Page 2 because 1 do not believe the wording of the p~-oposal is , ~-~"e~ paragraphs will undoubtedl3, be re~-~orded, but +},~..u o;)]~c[ive is to uze the methods mentioned in these p~ragraFhs to det~-~m~ne
Page 2: 00552849
Philip Grant -~r not the dogs are ~e~,~c~ the same amount of smoke e,_-.an. e~u ~ _ lVa.,enu amount as hun,'_an=bein~s get It is not intended, nor expected that +'~ne~-~ is anvthing~ about the test that would permit complete extrapolation of results on dogs to human beings. It is anticipated ~-~ ~' : ~ ~nzs work "~ be ~,~yu~ the six . ml~:.~.t extended ~ ..... d month ~eriod if it appears ~-~. {~'~ p~m .... n.~. It is also .... =~ -- ~ ~p~t~s that ~,<~ r~rut~ some of Auerbach's work the results here may ~=~nu = I wou! reciate your g~v~ng me your decisions with regard~ to these__ :two projects as early next weeK~ as possible. /{//~ " Last Tuesday, I talked with Gene Anderson and told him of the qenera! ~- _ resu~u~ with regard to the reports which you are going to have-Dr Spears examine next week° I will await word from you on this befe~e givin~ Anderson a copy of the reports ;--~ ~-, ~. ~ ,~-. - o " Sincerely, David R. Hard], DRH/v Enc. cc: John Russell

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