Tobacco Documents Online

't 34239 HKI474084 -~,r 7 CARBON t~ONOXIDE: SFI,0KIHG, AIR POLLUTION, CARDIOVASCULAR DISEASE, AND PHYS I OLOG I CAL HO~-~OEOSTAS IS LANCET 2(7828): 571-572; 1973 HICKEY, RJ/ CLELLAND, RC, BOYCE, DE LLT~: THE REPORTED (DocUMENT #32615) GREATER INCREASE IN CARBOXYHEMOGLOBIN (COHB) LEVELS IN SMOKERS COMPARED WITH NONSMOKERS AFTER EXPOSURE TO A CIGARETTE-SMOKE-FILLED ATMOSPHERE CONTAINING 38 PPM CARBON MONOXIDE (CO), AND THE "PUZZLING" IACK OF A SIGNIFICANT RELATION, FOR NONSMOKERS, BETWEEN THE AMOUNT OF CO ABSORBED AND DURATION OF EXPOSURE COULD BE EXPLAINED BY A CONSTITUTIONAL HYPOTHESIS: "THE HIGHER COHB FOR SMOKERS THAN FOR NON-SMOKERS...IS INFLUENCED SIGNIFICANTLY BY THE INDIVIDUAL CONSTITUTION OR GEN.OTYPE WHICH AFFECTS BOTH SMOKING BEHAVIOUR AND EFFICIENCY OF DETOXIFICATION.OF CO AND COHB," "THE SUSTAINED LOW COHB OF NON-SMOKERS MAY BE A CONSEQUENCE OF THEIR CONSTITUTIOt~ALLY HIGHER METABOLISING CAPABILITIES THAN THOSE OF SMOKERS, FURTHER, THE EFFECT OF NICOTINE (AND CAFFEINE) ON EFFICIENCY OF DETOX- IFICATION C; C0 OR COHB MAY BE BENEFICIAL," THIS HYPOTHESIS IS REPORTEDLY SUPPORTED BY DATA FROM ARONOW'S STUDY (DocuMENT #31562) OF ANGINA PATIENTS EXPOSED TO Los ANGELES FREEWAY AIR AND FRSH CASTLEDIN'S STUDY (DOCUMENT #33831) COtIPARING COHB LEVELS OF "PRIMARY" WITH THOSE OF "SECONDARY" PIPE AND CIGAR SMOKERS (DEFINED ACCORDING TO WHETHER THEY WERE NOT OR WERE FORMER CIGARETTE SMOKERS, RESPECTIVELY), ALTHOUGH THESE lATTER AUTHORS ATTRIBUTE THE DIFFERENCES IN CO~B LEVELS TO DEGREE OF INHALATION, IT IS CONTENDED THAT THESE DIFFERENCES COULD AS WELL BE EXPLAINED BY THE CONSTITUTIONAL HYPOTHESIS, /BW/ (SEE DOCUMENTS #32615, 31562, 33831,) U PE{iilS, PHILADELPHIA, PA/ U PEI;NS, PHILADELPHIA, PA CIR 98 EOHG 01222

,L',d ' 34239 Hl"rA 474085 LETTER TO EDITOR, CARBON MONOXIDE EXPOSURE, CIGARETTE SMOKE EXPOSURE, BLOOD CARBON MONOXIDE INCREASE, BLOOD CARBOXYHEMOGLOBIN INCREASE, CARBON MONOXIDE ABSORPTION, CIGARETTE SMOKING, NONSMOKERS~ BIOCHEMICAL MECHANISMS, CONSTITUTIONAL FACTORS, METABOLIC FACTORS, CARBON MONOXIDE DETOXIFICATION/ CONSTITUTIONAL FACTORS HI, NICOTINE BENEFICIAL EFFECTS CLAIMED, SMOKING METABOLIC EFFECTS HI, NICOTINE PHYSIOLOGICAL EFFECTS HI, INDIVIDUAL VARIABILITY HI, CARDIOVASCULAR DISEASE CONSTITUTIONAL FACTORS CAUSATION ~, SMOKING CONSTITUTIONAL FACTORS CAUSATION 1, SMOKING INHALATION DEGREE HI, ENERGY METABOLISM, HOtCEOSTASIS HI, AIR POLLUTION HEALTH EFFECTS, CARBON MONOXIDE PHYSIOLOGICAL EFFECTS, NITRIC OXIDE TOXICITY~ AIR NITRIC OXIDE, TOBACCO SMOKE NITRIC OXIDE, ADDITIVE: EFFECTS, AIR CARBON MONOXIDE CONTENT~ CARBON MONOXIDE EXPOSURE DURATION, PIPE SMOKING, CIGAR SMOKING, BIRTH WEIGHT DECREASE MATERNAL SMOKING CAUSATION 2 HI, BLOOD CARBON MONOXIDE INCREASE SMOKING CAUSATION 2 HI// ENGLISH LANGUAGE, PHILADELPHIA PA RESIDENCE, USA RESIDENCE, Los ANGELES CALIF, CORONARY ARTERY DISEASE PATIENTS [ ]'" I~ 98 C I[} Ill I~ 01~3