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28B14 HKl128010 5 CARDIAC RADIOTELEMETRY PSYCHOPHYSIOLOGY 8(1): ER~II~I, C,~l,// JOH;ISON, RATE RESPONSES TO CIGARETTE SI'IOKI~G: 7~-81, 1971 L.C., BRYSON, ['1, A STUDY UTILIZh~G 2 -" ~/,:'.-p:-P-_Y1 / P~,P ' RADIOTELEMETRY OF THE ELECTROCARDIOGRA~, INSTEAD OF THE! CONVENTIONAL DIRECT WIRE TECHNIQUE, WAS USED TO OBSERVE HEART RATE DURING SPONTANEOUS CIGARETTE SMOKING, '~L.T..ED.D..~: HEART RATE WAS MONITORED IN 10 MALE PSYCHIATRIC HOSPITAL PATIENTS (AGES 34-~3 YEARS) USING SMALL PORTABLE RADIO TRANSMITTERS, PERMITTING THE SUBJECTS TO MOVE ABOUT FREELY, THE OBSERVATION PER- IODS AVERAGED 1,8 HOURS OVER A 26 HOUR INTERVAL., REPRESENTING AN AVERAGE DF 50 CIGARETTES AND 511 PUFFS, ~: THE CARDIAC RATE DID NOT CHANGE BEFORE, DURING, OR AFTER THE SHOK!tUS OF A CIGARETTE, THERE WAS ~JO EVIDENCE THAT SMuKING AFFECTED THOSE SMOKERS WITH AN IN:TIALLY HIGHER HEART RATE, THERE WERE NO CONSISTENT RATE ALTERA- TIONS WHICH WERE NOT RELATED TO SOME OBVIOUS BEHAVIORAL ACTIVITY, TH~ SMOKI~;S RATE WAS NOT A SIGNIFICANT VARIABLE, P_~S~: "AT LEAST "/WO AUTHORS HAVE POINTED OUT THAT LABORATORY STUDIES O-- S~OKING IN MAN ARE NOT STRICTLY COMPARABLE TO A PERSD,"I~S SPg';TA:;ZC'.:S $::OKING gEHAVIC, R, THEY POINT OUT THAT THE PULSE RATE '.'; ;J.:BULA:;T SUBJECTS HAS NOT BEEf" STUDIED AND THAT PSYCHIC DISTHR- ~::;:-S, ~EEP BREATHII'IG, DRI::KIfIG A CUP OF HOT ',':ATER, ALL PRODUC:- =::-ECTS C~: THE HEART AS GREAT AS THOSE PRODUCED S't S,-:O~IIIG, THROUG~- O'.'T THE H.~STDRY OF PHYSIOLOGIC RESEARCH THERE HAS BEE.'; THE ?'..~ESTIC.'; ',','~:'E..THER RESPONSSS RECORDED Itl THE LABORATORY CO'JLD ~REnlCT R."Sr~S';~E~ ,:, T,.:: ;.',TL'-,',L [-tIVIRF, T.iL':'iT, I'; EI...'-"TRC)pHY(;IOLOG]C ST'tplr:~; "l'J.: EIF~ 98 Eor'lG 01 "11:?,,~,.

HKl128011 2881~ PROBLEM IS COMPOUNDED BY THE LABORATORY MILIEU WHICH IS OFTEN NEW AND FRIGHTENING TO THE SUBJECT, DUE TO THE ELECTRODE LEADs, THE SUBJECT HAS BEEN RESTRAINED EITHER IN FACT OR BY REQUEST .... "CLEARLY THIS DATA I$ AT VARIANCE WITH THE MAJORITY OF PREVIOIJ$ INVESTIGATIONS, ONE LIKELY EXPLANATION IS THAT IN THE MAJORITY OF PREVIOUS STUDIES THE CIGARETTE WAS PRESENTED WHEN THE SUBJECT'S HEART RATE WAS AT ITS LOWEST POSSIBLE LEVEL .... OBVIOUSLY INDIVIDU- ALS AT BASAL METABOLIC STATES HAVE ONLY ONE DIRECTION TO GO ..... ANOTHER PERTINENT DIFFERENCE IN THIS STUDY WAS THE LACK OF CONTROL OF THE SMOKING RATE, "To HAVE RIGOROUSLY CONTROLLED ALL THE FACTORS [WHICH INFLUENCE THE AXCUNT OF NICOTINE ABSORBED BY A SMOKER] WOULD HAVE DESTROYED THE INTENT OF THE STUDY AND PROBABLY WOULD HAVE INTRODUCED FACTORS EVEN ~ORE SIGNIFICANT, THE SMOKING RATE AND NICOTINE CONTENT OF THE CICARETTES WERE NOT FACTORS IN THIS STUDY," /BVIG/ DUKE U SCH FiED, DURHA:~, NC CARDIOVASCULAR STUDY, ELECTROPHYSIOLOGICAL STUDY, HEART RATE CHANGES SMOKING NONASSOC, "ALE DATA, TEN, CIGARETTE SMOKING/ HEART RATE CEAHGES MULTIPLE FACTORS CAUSATION i, HEART RATE CHANGES BE- HAVICR CHANGES ASSOC, CIGARETTE BRANDS, PUFF FREQUENCY HI, CIGARETTE NICOTINE CONTENT HI, J~IICOTINE ABSORPTION HI, HEART RATE CHANGES HI, S~CKI~.S BEHAVIOR, BASAL METABOLISM HI, ELECTROCARDIOGRAPHY, StrOKING A/.L3U;:T, PUFF COUNT, SMOKING RATE HI, S[.IOKING ;.~ITIATION, HEART RATE _..~,.,,~_m .,ICOTINE CAUSATION 3, ETIOLOGICAL CRITERIA HI, SMOKING CAR- ii --.r , ,,~ r., , g p _,,OV~,~,.L]~,-,R EFFECTS'HI, RESPIRATORY REFLEX, P-YSIOLOGICAL DATA .... l.~I,f HI, TELEMETRY/ ;IICOTINE CAT_CHOLA,.II,,_ RELEASE, [IICOTIIIE ..... :RGY, ,V3tJ~:.:OK:.RS, R ~'..~¢= CHANGES, CIGAR S~'~.')KI'IG, PIPE SHOKIt;G SIFI~_,,T," = GANGLIO,'~ STIr;'JLATIOtJ, EPINLPHRINE EXCRETIOI;, INHALATION "=~ "= LUNG ' "" ..~.R=~, CIGARETTE S ,O,k= RETENTION, PULSE RATE, CIGARETTE BUTT 'LE"'~:"~, ~'.~OKING HABITS Qi}T.STIONNAIRE/ ENGLISH LAII'3'JAGE, ~URHAtl IIC .........-.r~.,-:..~,.~, USA RESIDE;ICE, PSYCHIATRIC PATIENTS, u,,-..,~PITAL ...... p/,T1C, r-~ .......... ~U,.,~ ORY PATIEr;TS CTR 98 CLING 01185