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HK0270172 • 37252 5 CARBOXYHEMOGLOBIN DETEPJIINATION IN EVALUATING NEONATAL JAUNDICE • AMEN J DIs CHILDR 127(2)' 214-2.17; 1974 ALDEN, ER/ LYNCH, SR, WENNBERG, RP PURPOSE~: IN A STUDY AIMED PRIMARILY AT DIFFERENTIATiNG'HEMOLYTIC FROM NON-HEMOLYTIC CAUSES OF NEONATAL JAUNDICE AND DETERMINING THE RELA- TIONSHIP OF CARBOXYHD~OGLOBIN (COHB) CONCENTRATION TO THE SEVERITY OF HEMOLYTIC DISEASEI THE EFFECTS OF MATERNAL SMOKING ON NEWBORN COHB LEVELS WERE ALSO INVESTIGATED, ~: BLOOD CARBON MONOXIDE, HEMOGLOBIN, AND SERUM BILIRUBIN WERE DETERMINED FOR FOUR NORMAL INFANTS WHOSE MOTHERS SMOKED DURING LA3ORs11 NORMAL INFANTS OF NONSMOKING MOTHERS, 10 INFANTS WITH ERY- THROBLASTOSIS FETALIS BORN TO NONSMOKING MOTHERS, ANDt6 INFANTS WITH IDIOPATHIC HYPERBILIRUBINEMIA, SAMPLES OF MATERNAL AND CORD BLOOD WERE OBTAINED DURING DELIVERY AND FROM INFANTS AT 24 HOURS AFTER BIRTH, ~_I~IJZt.[~CL~_L CARBOXYHEMOGLOBIN LEVELS IN WOMEN WHO SMOKED WERE SIGNIFI.- CANTLY HIGHER THAN THOSE IN NONSMOKERS, MEAN CORD BLOOD • CARBON MONOXIDE CONCENTRATION WAS SIGNIFICANTLY HIGHER FoR SMOKERS AS COMPARED TO NORMAL NONSMOKERS, AND INSIGNIFICANTLY HIGHER AS COMPARED TO THE ERYTHROBLASTOTI.C GROUP, AT 24 HOURS OF AGE, THERE WERE NO SIGNIFICANT DIFFERENCES IN CONB LEVELS BETWEEN NORMAL INFANTS OF SMOKERS AND NONSMOKERS, WHILE COHB REMAINED SIGNIFICANTLY ELEVATED IN THE HEMOLYTIC DISEASE GROUP, ]~CU_E,~..ION: "IF THE MOTHER SMOKES OR HAS BEEN IN A POLLUTED ENVIRON" MENT SHORTLY BEFORE DELIVERY, THE INFANT'S C0HB MAY BE ELEVATED DUR- ING THE FIRST DAY OF LIFE,,,,SINCE INVESTIGATION OF IDIOPATHIC JAUN- plCE IS RARELY INITIATED IN THE FIRST DAY OF LIFE, THE PROBLEM OF HA" TERNAL SMOKING IS ESSENTIALLY CONFINED TO THE EVALUATION OF SEVERE ClR 98 CLqI,IG 0:1047

WC HK0270473 ;,J • 37252 HEMOLYTIC DISEASE OF THE NEHBORN," /GSI)/ U WASH SCH MED, SEATTLE, WASH; MADIGAN ARMY NED CENT, FORT LEWIS, WASH/ U WASH SCH BED, SEATTLE, WASH; U WITW NED SCH, JOHAIINESBURG, SOUTH AFRICA CLINICAL STUDY, HEMATOLOGICAL STUDY~ FEMALE DATA, MATERNAL DATA, CLINICAL DATA, HUNDRED, BLOOD CARBON MONOXIDE INCREASE SMOKING ASSOCa FETAL BLOOD CARBON MONOXIDE MATERNAL SMOKING ASSOC, FETAL BLOOD CARBON MONOXIDE MATERNAL BLOOD CARBON MONOXIDE ASSOC, INFANT BLOOD, UMBILICAL CORD BLOOD, TOBACCO SMOKING, FEMALE SMOKING HABITS, HONSMO,KERS~ BLOOD CARBON MONOXIDE MECHANISMS, HEMATOLOGICAL DISORDERS, NEONATAL HYPOXEMIA, JAUNDICE/ FETAL BLOOD CARBON MONOXIDE MATERNAL SMOKING CAUSATION ~, BLOOD CARBON MONOXIDE INCREASE PASSIVE SMOKING CAUSATION 1, BLOOD CARBON MONOXIDE INCREASE AIR POLLUTION CAUSATION 1, BLOOD CARBON MONOXIDE SATURATIONs BLOOD CARBON MONOXIDE CONTENT, BLOOD CARBON MONOXIDE DECREASE, MATERNAL BLOOD GROUP, MATERNAL INFLUENCE, HYPERBILIRUBINEMIA, CARBOXYHEMOGLOBIN, RH BLOOD GROUP, RHESUS FACTORS, SERUM BILIRUBIN CHANGES# ERYTHROBLASTOSIS FETALIS, HEMOLYTIC DISEASE, HEMOGLOBIN DETERMINATION, FETAL HEMOGLOBIN, ISOIMMUNIZATION, CARBON MONOXIDE METABOLISM, CARBON MONOXIDE SOURCES,, CARBON MONOXIDE PRODUCTION, CARBON MONOXIDE SUSCEPTIBILITY/ BLOOD CARBON MONOXIDE ANALYSIS, GAS CHROMATOGRAPHY, BLOOD TRANSFUSIONS~ HEMOLYSIS, HEMOCHROMATOSIS, CARBON MONOXIDE EXPOSURE, AIR POLLUTION EXPOSURE, HEMATOORIT, CO0~BS TEST, ~RYTHROCYTE, GESTATION PERIOD, PREGNANCY DURATIDN, BREAST FEEDING, RESPIRATORY DISTRESS SYNDROME, BLOOD GROUP~ INFANT INFECTION, VIRUS INFECTION, DIABETES, HYPOTHYROIDISM, HYALINE MEMBRANE DISEASE, POLYCYTHEMIA, RETICULOCYTE COUNT, HEMATOLOGICAL EXAMINATION/ [~TF~ 9B COI'IG O'104B

• 37252 HK0270174 ENGLISH LANGUAGE, SEATTLE WASH RESIDENCE, FORT LEWIS WASH RESIDENCE, USA RESIDENCEs JOHANNESBURG RESIDENCE, SOUTH AFRICA RESIDENCE, GRANTOR USPHS, OBSTETRICAL PATIENTS, INFANTS, CHIldREN E~IR 9B COHI5 0'1049