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HK0270'121 37089 6 PREDICTI~IG THE CARBOXYHB, IOGLOBIN LEVELS RESULTING FROM CARBnN MONOXIDE EXPOSURES UNPUBLISHED PAPER 0(0): 1-46; 1973 PETERSON, JE/ STEWART, RD/ BACHAND, E, BARETTA, ED, DODD, HC, DONOHO0, KK, GRAFF, SA, HAKE, CL, NEWTON, PE ~U~_IZ~t~! DATA FROM A SERIES OF HUMAN EXPOSURES TO CARBON MONOXIDE (CO) HERE ANALYZED TO EXAMINE THE EFFICIENCY OF A THEORETICAL EQUATION IN PREDICTING THE BLOOD C0 LEVELS RESULTIHG FROM CARBON MONOXIDE EXPOSURES. FINDINB~: nTHE EQUATION HAS FOUND TO PREDICT CARBOXYHEMOGLOBIN (COHB) LEVELS FOR BOTH MEN AND WOMEN AT [VARIOUS] EXERCISE RATES ,,, WHEN THEY HERE EXPOSED TO STEADY CO CONCENTRATIONS OF 50, 100, AND 200 PPM FOR 0,33 TO 5,25 HOURS, IN ADDITION, THE EQUA- TION ACCURATELY SUMMED THE RESULTS OF A DISCONTINUOUS EXPOSURE TO CO," ~.~JI~ON: "EVEN THOUGH THE ,,, EQUATION HAS NOT BEEN COMPLETELY TESTED AT ALL LEVELS OF ALL PARAMETERS (AND SUCH TESTING IS, IN FACT, IMPOSSIBLE), PRESENT INDICATIONS ARE THAT IT DESCRIBES UPTAKE AND EXCRETION OF CO VERY HELL, THIS EQUATION APPEARS SUITABLE FOR GENERAL USE IN PREDICTING THE CONSEQUENCES OF SPECI- FIC CIRCUMSTANCES AS HELL AS FOR SUMMING MORE OR LESS LONG-TERM EXPOSURES TO VARYING CONCENTRATIONS," /nMl ME]) COLL WISC ALL BRADL MED SCI LAB, MILV/AUKEE, HIS/ MEI) COLL WISC ALL BRADL MEI} SCI LAB, MILWAUKEE, WIS

% HK0270122 37089 HEMATOLOGICAL STUDYs MATHEHATICAL STUDY, METHODOLOGY STUDY, INHALATION STUDY, MALE FEMALE DATA, HUNDRED, BLOOD CARBON MONOXIDE ANALYSIS, MATHEMATICAL MODEL, CARBON MONOXIDE EXPOSURE DURATION, DOSIMETRY, INHALANT DOSE/ CARBOXYHEHOGLOBIN, CARBON MONOXIDE INHALATION, CARBON MONOXIDE EXCRETION, CARBON MONOXIDE EXHALATIONs METHODOLOGY ANALYSIS, CARBON MONOXIDE ELIHINATION, CARBON MONOXIDE UPTAKEs LUNG CARBON HONOXIDE RETENTION, ENDOGENOUS CARBON MONOXIDEs BLOOD CARBON HONOXIDE HI~ CARBON HONOXIDE HETABOLISM, BLOOD CARBON HONOXIDE SATURATION, INDIVIDUAL VARIABILITY, PHYSICAL EXERCISE TEST~ BLOOD CARBON MONOXIDE INCREASE PHYSICAL ACTIVITY CAUSATION 1/ DRUG ADMINISTRATION ROUTE~ OXYGEN THERAPY~ INHALATION THERAPY, COMPUTER ANALYSIS, ARTERIAL OXYGEN TENSION, ARTERIAL CARBON'. DIOXIDE TENSION, LUNG DIFFUSING CAPACITY, RESPIRATORY RATE, STATISTICAL ANALYSIS, OXYGEN CONSUMPTIONs BLOOD VOLUME, OXYHEHOGLOBIN SATURATION, SEDENTARY ACTIVITY, HEMOGLOBIN, EXPIRED AIR CARBON MONOXIDE DETERMINATION, BICYCLE ERGOMETER, CORRELATION COEFFICIENTS, SEX FACTORS, THRESHOLD LIMIT VALUE/ ENGLISH LANGUAGE, MILWAUKEE WIS RESIDENCE, USA RESIDENCE, GRANTOR COORDINATING REs COUNCIL, GRANTOR US ENVIRONMENTAL PROTECTION AGENCY, CAUCASIANS, VOLUNTEERS CIR 98 COHG 010,i-E,