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HK0270110 5 EFFECT OF CIGARETTE SMOKING AND BREATHING cARBoII Mr)Nr)XIDE nN CARDIOVASCULAR HE/'IODYI'LA/IICS IN ANGIMAL PATIENTS CIRCULATION 50(2). 340-347~ 1974 ARONO~'I, WS/ CASSIDY, J, VANGROW, JS, MARCH, H, KERN, JC, GOLDSMITH, JR, KHEMKA, M, PAG~JO, J, VA~q'ER, /I/ ISBELL, MW, BOSWELL, R PURPOSE: WHETHER OR NOT CIGARETTE SMOKING AND BREATHING CARBON MONOXIDE (CO) AFFECT CARDIOVASCULAR HEMODYNAMICS WAS EVALUATED IN ANGINAL PATIENTS, METHODS: CARDIAC CATHETERIZATION TO MEASURE VARIOUS HEMODYNAMIC FACTORS WAS PERFORMED TWICE, ONE WEEK APART, ON EIGHT MEN WITH SEVERE ANIGNA PECTORIS WHO REPORTEDLY SMOKED BETWEEN 20 AND 30 CIGARETTES DAILY, AFTER CONTROL MEASUREMENTS WERE MADE DURING THE FIRST CARDIAC CATHETERIZATION, THE SUBJECT SMOKED FOUR-FIFTHS OF THREE STANDARD BRAND, NONFILTER, HIGH-NICOTINE CIGARETTES AT HIS NORMAL PACE, INHALING THE SMOKE, MEASUREMENTS HERE TAKEN AT VARIOUS INTERVALS AFTER SMOKING EACH CIGARETTE, AFTER CONTROL MEASUREMENTS WERE MADE DURING THE SECOND CARDIAC CATHETERIZATION, THE PATIENT BREATHED 150 PPM OF CARBON MONOXIDE FROM A TANK THROUGH A MASK UNTIL THE INCREASE IN CORONARY SINUS C~ WAS SIMILAR TO THAT EXPERIENCED AFTER SMOKING THEIR THIRD CIGARETTE, LEFT VENTRICULOGRAPHY AICD CORONARY ANGIOGRAPHY WERE PERFORMED AFTER COMPLETIOR OF THE MEASUREMENTS, FINDINGS: SMOKING HIGH-NICOTINE CIGARETTES ALLEGEDLY CAUSED A SIGNIFICANT INCREASE IN SYSTOLIC AND DIASTOLIC ARTERIAL PRESSURE, HEART RATE, LEFT VENTRICULAR END-DIASTOLIC PRESSURE, AND CORONARY CTR 9B CONG 0104.2

HK0270111 37043 SINUS, ARTERIAL, AND VENOUS CO LEVELS, NO SIGNIFICANT CHANGE IN LEFT VENTRICULAR PRESSURE RISE, AORTIC SYSTOLIC EJECTION PERIODs AND CARDIAC INDEX, AND A SIGNIFICANT DECREASE IN STROKE INDEX AND CORONARY SINUS, ARTERIAL, AND VENOUS OXYGEN TENSION LEVELS IN EIGHT ANGINAL PATIENTS WITH DOCUMENTED CORONARY DISEASE, INHALING CARBON MONOXIDE ALLEGEDLY CAUSED A SIGNIFICANT INCREASE IN LEFT VENTRICULAR END-DIASTOLIC PRESSURE AND CORONARY SINUS, ARTERIAL, AND VENOUS CO LEVELS, NO SIGNIFICANT CHANGE IN SYSTOLIC AND DIAS- TOLIC ARTERIAL PRESSURE, HEART RATE, AND SYSTOLIC EJECTION PERIOD, AND A SIGNIFICANT DECREASE IN LEFT VENTRICULAR PRESSURE RISE, STROKE " INDEX, CARDIAC INDEX, AND'CORONARY SINus, ARTERIAL, AND VENOUS OXYGEN LEVELS, ~: "NICOTINE CAUSED THE INCREASED SYSTOLIC AND DIASTOLIC ARTERIAL PRESSURE AND HEART RATE AFTER SMOKING, CARBON MONOXIDE CAUSED THE NEGATIVE INOTROPIC EFFECT WHICH 'INCREASED THE LEFT VEN- TRICULAR END-DIASTOLIC PRESSURE AND DECREASED THE STROKE INDEX AFTER SMOKING," /EAF/ VA HOSP, LONG BEACH, CALIF/ VA HOSP, LONG BEACH, CALIF; U CAL COLL MEg, IRVINE, CALIF; CAL STATE DEPT PUBL HEALTH, BERKELEY, CALIF SMOKING TESTs INHALATION STUDY, CARDIOVASCULAR STUDY, TENs MALE DATA, BLOOD CARBON MONOXIDE INCREASE SMOKING ASSOC, BLOOD PRESSURE INCREASE NICOTINE ASSOCa INOTROPIC EFFECTS, CIGARETTE SMOKINGa CARBON MONOXIDE INHALATIONs SMOKING HEMODYNAMIC EFFECTS, ANGINA PECTORIS, SMOKING INHALATION, LEFT VENTRICLE END DIASTOLIC PRESSURE INCREASE, BLOOD OXYGEN TENSION DECREASE, STROKE INDEX DECREASE, SMOKING CARDIOVASCULAR EFFECTS, CARBON MONOXIDE CARDIOVASCULAR EFFECTS, NICOTINE CARDIOVASCULAR EFFECTS, BLOOD E:I~R 98 COHG 0'1043

| HK0270112 37043 PRESSURE INCREASE SHOKING ASSOC/ SYSTOLIC BLOOD PRESSURE 1NCREASE SMOKING ASSOC, DIASTOLIC ~LOOD PRESSURE INCREASE SHOKING ASSOC~ SMOKING AMOUNT, CIGARETTE NXCOTINE CONTENT, HEART RATE |NCREASE SHOKING ASSOC, HEART INDEX, ARTERIAL OXYGEN TENSION DECREASE SHOKING ASSOC, VENOUS OXYGEN TENSION DECREASE, BLOOD PRESSURE CARBON HONOXIDE NONASSOC, HEART RATE CARBON HONOXIDE NONASSOC, SHOKING POSITIVE DOSE RESPONSE, OXYHEHOGLOBIN DISSOCIATION CURVE, HEART RATE |NCREASE NICOTINE ASSOC, SYSTOLIC DURATION CHANGES/ AORTA, PULHONARY ARTERY~ HEART OUTPUT~ HEART CATHETERIZATION, CORONARY SINUS, VENTRIGULOGRAPHY, CORONARY ANGIOBRAPHY, INDOCYANINE GREENs DYE DILUTION HETHODs OXIHETRY, BLOOD CAR30N MONOX|DE ANALYSIS, PHYSICAL EXERC|SE~ ~!ICOTINE FREE CIGARETTES, BLOOD PRESSURE INCREASE NICOTINE CAUSATION ~ HEART RATE iNCREASE NICOTINE CAUSATION 1, BLOOD CARBON HONOXiDE INCREASE: SHOKING CAUSATION 1~ CARBOXYHEMOGLOBIN, ~YOCARDIAL OXYGEN CONSUHPTION, CHROMAFFIN TISSUE, CAROTID CHEHORECEPTORS, AORTIC CHEHORECEPTORS, SYHPATHETIC GANGLIA CELL$~ STATISTICAL ANALYSIS, HICOTiNE CATECHOLAHiNE RELEASE/ ~NGLISH LANGUAGE, US~ RESIDENCE~ LONG ~EACH CAL|F RESIDENCE, |RViNE CALIF RESIDENCE, ~ERKELEY CALIF RESIDENCE, CORONARY ARTERY DISEASE PATIENTS E]R 00H13