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HK0270075 3, 5 ABSORPTION AJ'ID RELEASE OF CARBON MONOXIDE DURING BREATHING OF LOW CO COtlCENTRATIONS BY SMOKERS AND NONSMOKERS STALB REINHALT LUFT 32(4): 43~46J 1972 NN'|SEN, O/WILK£, H, MALOP~JY, G, GOETHERT, M PURPOSE1 "SINCE MANY A MAN WHO HAD ALREADY ABSORBED CO BY CIGARETTE SMOKING HAS AFTERWARDS TO BREATHE C0-CONTAINING AIR IN TRAFFIC OR AT WORK, IT IS NECESSARY TO CLARIFY HOW THE CO ABSORPTION OF SUCH PERSONS IS AFFECTED, IN COMPARISON WITH NON- SMOKERS," THIS STUDY EXAMINES THE ABSORPTION AND RELEASE OF CARBON MONOXIDE (CO) DURING INHALATION OF LOW CO CONCENTRATIONS BY CIGARETTE SMOKERS AND NONSMOKERS, ~L EXPIRED AIR CO AND BLOOD CARBON MONOXIDE LEVELS WERE EXAMINED IN 21 FEMALES AND 57 MALES, AGED 19 TO 40 YEARS, (IN- CLUDING 40 S~$OKERS) EXPOSED TO 50 OR 200 PPM CO FOR 3.5 HOURS. THE SUBJECTS WERE NOT ALLOHED TO SMOKE DURII~IG THE TESTS. AB- SORBED CO VIAS CALCULATED AS THE DIFFERENCE BETV/EEN INSPIRED AND EXPIRED CO. N~I_N.JZI_I~_S..L NONSMOKERS ABSORBED MORE CO IN A GIVEN PERIOD THAN DID SMOKERS, CO UPTAKE WAS RAPID AT FIRST, THEN CONTINUED SLOWLY, IN SMOKERS EXPOSED TO 200 PPM CO AFTER SMOKING, THE ALVEOLAR C0 PLOTTED AGAINST TIME RAN PARALLEL TO AND ABOVE THAT FOR NON- SMOKERS FOR THE ]ST ~.5 HRJ EQUILIBRATION WITH THE AMBIENT CO WAS REACH,ED IN BOTH CASES AFTER 8-]0 HR. AFTER REMOVAL OF THE SUBJECTS FROM THE EXPOSURE CHAJ~ER, CO EXPIRATION FOLLOWED THE SAME COURSE IN REVERSE. (]TR 98 COHI3 01033

I i I HK0270076 33623 AFTER BREATHING 50 PPM CO FOR 3,~ HR, NONSMOKERS AND SMOKERS (INITIAL ALVEOLAR CO CONCENTRATIONS 0 AND 24 PPM RESPECTIVELY) HAD ABSORBED ~'~ AND 24 ML CO FROM THE AIR, RESPECTIVELY, SMOKERS REACHED A STATE OF EQUILIBRIUM FASTER THAN NONSMOKERS AT THIS EX- POSURE LEVEL, DISCUSSION: #IN THE LIGHT OF OUR PRESENT KNOWLEDGEj CO CAN BE EXPECTED TO HAVE A TOXIC EFFECT ONLY WHEN THE CO SATURATION OF THE ORGANISM EXCEEDS A CERTAIN THRESHOLD VALUE, SINCE THE CO CON- CENTRATION IN THE ALVEOLAR AIR OF SMOKERS EXPOSED TO LOW CON- CENTRATIONS OF CO IS HIGHER THAN THAT OF NONSMOKERSa THIS THRES- HOLD VALUE CAN BE EXPECTED TO BE REACHED SOONER BY SMOKERS THAN BY NONSMOKERS, OUR EXPERIMENTS GAVE NO CLUE AS TO THE EXTENT TO WHICH THIS EFFECT MIGHT BE COMPENSATED BY AN ~IABJUSTMENTr TO CO," U HAHB U H~B I PHAIVI, HAtIBURG, GERMANY/ I PHARM, HAMBURG, GERMAIIY IOM/ < TOXICITY STUDY, INHALATION STUDY, AIR POLLUTION STUDY, PHYSIOLOGICAL STUDY, MALE FEMALE DATA, HUNDRED, CIGARETTE SMOKING, ~ONSMOKERS, CARBON MONOXIDE INHALATION, ALVEOLAR CARBON MONOXIDE, CARBON~ MONOXIDE ABSORPTION, BLOOD CARBON MONOXIDE INCREASE/ EXPIRED AIR CARBON MONOXIDE INCREASE SMOKING ASSOC, CARBON MONOXIDE EXPOSURE DURATION, CARBON MONOXIDE ABSORPTION HI, BLOOD CARBON MONOXIDE SATURATION, CARBON MONOXIDE ELIMINATION, BLOOD CARBON MONOXIDE INCREASE SMOKING ASSOC, CARBON MONOXIDE TOXICITY, CARBON MONOXIDE EXHALATION, LUNG CARBON MONOXIDE RETENTION,METHODOLOGY ANALYSIS, METHODOLOGY CONCESSION, SMOKING PHYSIOLOGICAL EFFECTS, SMOKING RESPIRATORY EFFECTS,AIR POLLUTION HEALTH EFFECTS, CARBON MONOXIDE ADAPTATION, THRESHOLD LIMIT VALUE, CARBOXYHEMOGLOBIN, 4, CI-F~ 98 COHLS 0I03~

-D i I HK0270077 35623 ALVEOLAR CARBON HONOXIDE INCREASE SHOK]NG CAUSATION 1/ AIR CARBON HONOXIDE CONTENTs SMOKING A.B. STINENCEs CIGARETTE SHOI(E CARBON MONOXIDE CONTENTs SMOKING AHOUNTs MINUTE VOLUMEs BLOOD CARBON MONOXI DE ANALYSIS s. UP'AN FACTORSs INTERNAL. COI'~UST1 ON ENGINE$s CIGARETTE LENGTHs MOTOR VEHICLE EXHAUST~ INFRARED CARBON MONOXIDE ANALYZER/ ENGLISH LANGUAGE, HAHBURG RESIDENCE', GERHANY RESIDENCEs VOLUNTEERS C1-R $8 CDHB 0'103'.S