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J HK0270067 32066 5,7 PATHOLOGICAL EFFECTS OF MODERATE CARBON MONOXIDE EXPOSURE STAUB REINHALT LUFT 32(4): 146-149, 20-23~" 1972 ASTRUP, P R~VIEW: THE AUTHOR SUMMARIZES INVESTIGATIONS HE HAS CONDUCTED INTO THE EFFECT OF PROLONGED CARBON MONOXIDE EXPOSURE ON ATHEROGENESIS AND FETAL DEVELOPMENT IN RABBITS. (14 REFS) DrscusE~U: "[A] MODERATE CARBON MONOXIDE EXPOSURE HAS A SEVERE EFFECT ON THE FOETAL DEVELOPMENT IN RABBITS BY REDUCING THE BIRTH WEIGHT AND BY INCREASING THE NUMBER OF STILL.BORN AND OF BABIES DYING WITHIN 24 HOURS, INCREASED CARBOXYHEMOGLOBIN CONCENTRATIONS IN SMOK- ING PREGNANT WOMEN RAY HAVE A SIMILAR EFFECT,,,, "SOME OF THE BABIES OF THE EXPOSED [RABBIT] MOTHERS WERE BORN WITHOUT A LEGj THUS DEMONSTRATING ALSO A TERATOGENIC EFFECT OF CARBON MONOX" IDE,,, "[L]IPID ACCUMULATION IN THE ARTERIAL WALLS IS HIGHLY INFLUENCED BY THE COMPOSITION OF THE AIR THE ANIMALS BREATHE, INCREASED BY HYPOXIA AND CARBON MONOXIDE AND DECREASED BY HYPEROXIA,,,, \ "THE RESULTS'OF OUR EXPERIMENTAL WORK DEFINITELY PRovED A DAMAGING EFFECT OF CARBON MONOXIDE ON THE ARTERIAL WALLSj LEADING TO AN IN- CREASED PERMEABILITY FOR VARIOUS PLASMA COMPONENTS, TO THE FORMATION OF SUBENDOTHELIAL EDEMA AND TO INCREASED ATHEROMATOSIS, IECHI U COP HOSP, COPENHAGEN, DE(~r~RK REVIEW, ANIMAL MODEL EXTRAPOLATION, ARTERIOSCLEROSIS INDUCTION A, CTR 98 C.BHG 01030

HK0270088 32066 ARTERIOSCLEROSIS CARBON MONOXIDE ASSOC A, ARTERIAL LESIONS A, NEONATAL MORTALITY A, STILLBIRTH INCREASE A,. TERATOGENIC EFFECTS A,. CIGARETTE SMOKE CARBON MONOXIDE C~NTENT, CARBON MONOXIDE EXPOSURE A, CARBON MONOXIDE INHALATION A, ATHEROGENESIS A,ARTERIOSCLEROSIS PATHOGENESIS A, ATHEROMATOSIS A, FETAL HYPOXIA A, CARBON MONOXIDE TOXICITY, CARBON MONOXIDE TOXICITY A/ ARTERIAL LIPID DEPOSITION A, ARTERIAL WALL CHANGES A, BIRTH WEIGHT DECREASE CARBON MONOXIDE CAUSATION 2, NEONATAL MORTALITY MATERNAL SMOKING CAUSATION 2, STILLBIRTH MATERNAL SMOKING CAUSATION 2, BLOOD CARBON MONOXIDE INCREASE SMOKING CAUSATION 1, CARBOXYHEMOGLOBIN, ATHEROGENESIS HYPOTHESIS A, ATHEROGENIC DIET A, CIGARETTE SMOKING, ARTERIAL PERMEABILITY CHANGES A, ARTERIAL ENDOTHELIUM A, VASCULAR EDEMA A, OTHER FACTORS CONCESSION, RABBITS, ATHEROGENESIS HYPOTHESIS, BIRTH WEIGHT DECREASE MATERNAL SMOKING CAUSATION 1, CARBON MONOXIDE EXPOSURE~ CARBON MONOXIDE INHALATIONe ARTERIOSCLEROSIS SMOKING CAUSATION 1, ARTERIOSCLEROSIS CARBON MONOXIDE CAUSATION 1~ ARTERIOSCLEROSIS RISK FACTORS, CARBON HONOXIDE EXPOSURE DURATION A, BLOOD CARBON MONOXIDE INCREASE A, HYPEROXIA A, HYPOXIA As PREGNANCY A, CONGENITAL MALFORMATIONS A, ARTERIOSCLEROSIS PATHOGENESIS, NONSMOKERS, FETAL DEVELOPMENT, FETAL DEVELOPMENT A, ARTERIOSCLEROSIS DIAGNOSIS, FEMALE SMOKING HABITS/ PERIPHERAL ARTERIOSCLEROSIS, ARTERIOSCLEROSIS RISK INCREASE~ ~IICOTINE CARDIOVASCULAR EFFECTS A, OXYGEN A, HITROGEN A, MONKEYS, AORTIC CHOLESTEROL INCREASE A, AORTIC INTIMA LIPID CONTENT' A, ARTERIOSCLEROTIC PLAQUES A, MICROSCOPY, ELECTRON MICROSCOPY, ARTERIAL HISTOLOGY A, PLATELET AGGREGATION INCREASE A, PHYSIOLOGICAL FACTORS, BIOCHEMICAL FACTORS, PLETHYSMOGRAPHY, GLOMERULUS FILTRATION RATE, X RAY THERAPY, THRESHOLD LIMIT VALUE~ AIR POLLUTION CONTROL, ENVIRONMENTAL HAZARDS PREVENTION, INHALATION CHAMBER A, SMOKING AMOUNT, CHOLESTEROL DIET A, ARTERIAL INJURY A, ALTITUDE FACTORS, CAPILLARY FILTRATION, BLOOD LIPID~ ARTERIAL PRESSURE, ARTERIAL PRESSURE A, ANGINA PECTORISs CIGARETTE SMOKE COMPOSITION/ ENGLISH LANGUAGE, COPENHAGEN RESIDENCE, DENMARK RESIDENCE, JUflGFRAUJOCH SWITZERLAND~ SURGEON GENERALS REPORT, ARTERIOSCLEROSIS ETR 98 cor,IG 01031

I B HK0270069 32066 PATIENTS, COROHARY ARTERY DISEASE PATIENTS, |NFAHTS, FETUS A 0BSTETRICAL PATIENTS, CTR 98 E:ONB 0:1032