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,e, HK0270049 szsoo S ULTRASTRUCTURAL INTIMAL CHANGES IN THE RABBIT AORTA AFTER MODERATE CARBON MONOXIDE EXPOSURE ATHEROSCLEROSIS 16(1): 67-82; 1972 KJELDSEN, K/ ASTRUP, P, WA~ISTRUP, J/ HVIID, B, NORGAARD, A, BRETLAU, P, HANSEN, HJS, NIELSEN, M ~_9.S~L: ULTRASTRUCTURAL CHANGES WERE EVALUATED IN THE INTIMA AND SUBINTIMA RABBIT AORTA FOLLOWING LIGHT CARBON MONOXIDE,(Cq) EXPOSURE, THIS IS AN EXTENSION OF LIGHT MICROSCOPY STUDIES WHICH FOUND AN ASSOCIATION BETWEEN ARTERIAL AND MYOCARDIAL LESIONS AND CO EXPOSURE, I~..l.lfo.IA.~: EIGHT MALE ALBINO RABBITS WERE FED A NORMAL DIET; FOUR WERE EXPOSED TO 0.018 VOL. I CARBON MONOXIDE FOR 2 WEEKS, WHILE THE OTHER 4 SERVED AS CONTROLS AND WERE EXPOSED TO ATMOSPHERIC AIR, AT THE END OF THE STUDY TISSUE FROM THE ARCH AND THORACIC AORTA V/AS TAKEN FOR TRANSMISSION AND SCANNING ELECTRON MICROSCOPY, ~: "THE LUMINAL AORTIC COATS OF THE EXPERIMENTAL ANIMALS SHOWED PRONOUNCED CHANGES, CHARACTERIZED FIRST OF ALL BY A SEVERE EDEMATOUS REACTION WITH EXTENSIVE SWELLING, FORMATION OF SUBENDO- THELIAL BLISTERS, AND PLAGUE FORMATION. FURTHERMORE, THE MYOIN- TIMAL (:ELLS SHOWED VACUOLATION AND OCCASIONALLY THE ENDOTHELIAL CELLS SHOWED SEVERE DEGENERATION WITH CYTOLYSIS AND CONDENSATION. APART FROM ACTUAL PLAQUE FORMATION, THE SURFACE STRUCTURES WERE MARKEDLY SWOLLEN AND IRREGULAR. OCCASIONALLY SPOTTY OR STREAKY LESIONS OCCURRED, WHERE THE NORMAL FOLDING ARCHITECTURE HAD. CHANGED INTO A CHARACTERISTIC 'COBBLESTONE-LIKE' PICTURE FORMED BY PROTRUDING, GROSSLY EDEMATOUS ENDOTHELIAL'CELLS.N DIscuss I_O~: "THE RESULTS SUPPORT EARLIER FINDINGS OF TOXIC EFFECTS OF LOW CONCENTRATIONS OF CARROXYHAEMOGLOBIN ON THE ARTERIAL ETR 98 COl'IS 01028

w T • I HK0270050 11,.- 31800 HALLSs THEREBY PROVOKING INCREASED ENDOTHELIAL PERMEABILITY AND FORMATION OF EDEMA, LEADING TO CHANGES INDISTINGUISHABLE FROM EARLY ATHEROSCLEROSIS,,,, THE MEDICAL IMPORTANCE OF THESE FINDINGS DERIVES FROM THE FREQUENT OCCURRENCE IN SMOKERS OF HIGH CARBOXY- HAEMOGLOBIN LEVELS, QUITE OFTEN BETWEEN 10 AND 20Z AND THE HIGH INCIDENCE OF ARTERIAL DISEASES IN SMOKERS, THUS INDICATING THAT THE CARBON MONOXIDE CONTENT OF TOBACCO SMOKE IS A FACTOR OF MAJOR IMPORTANCE IN THE DEVELOPMENT OF OBLITERATING ARTERIAL DISEASES," ISLK/ U COP HOSP, COPENHAGEN, DEtlMARK/ U COP HOSP, COPE~IHAGEN, DENMARK INHALATION STUDY A, CARDIOVASCULAR STUDY As HISTOPATHOLOGICAL STUDY A, AUTOPSY STUDY A, RABBITS, ~IALE DATA As TEN, CARBON MONOXIDE EXPOSURE As CARBON MONOXIDE TOXICITY As ARTERIOSCLEROSIS INDUCTION A, ARTERIOSCLEROSIS BLOOD CARBON MONOXIDE ASSOC A, ARTERIOSCLEROSIS CARBON MONOXIDE AGSOC As AORTIC LESIONS As CELL ULTRASTRUCTURE CHANGES As AORTIC HISTOPATHOLOGY ~ CARBON MONOXIDE CARDIOVASCULAR EFFECTS A/ ALBINO RABBITS, ATHEROGENESIS A, CARBOXYHEMOGLOBIN ~a AORTIC ARTERIOSCLEROSIS AJ AORTIC INTIMA LESIONS A, AORTIC FIBROUS PLAQUES A, AORTIC FATTY STREAKS Aa VASCULAR EDEMA A, VASCULAR PERMEABILITY INCREASE A, CYTOPLASMIC VACUOLATION ha CELL DEGENERATION A, HYPOXIA A, CORONARY ARTERY DISEASE SMOKING CAUSATION i, ARTERIOSCLEROSIS SMOKING CAUSATION i~ ARTERIOSCLEROSIS NICOTINE CAUSATION 2 HI, ATHEROGENESIS HI, BLOOD CARBON MONOXIDE SMOKING CAUSATION 1, ~RTERIOBCLEROSIS CARBON MONOXIDE CAUSATION l~ ARTERIOSCLEROSIS SITE A~ CIGARETTE SMOKE CARBON MONOXIDEs CARBON MONOXIDE TOXICITY, CIGARETTE SMOKING/ ELECTRON MICROSCOPY, THORACIC AORTA As MICROSCOPY/ ENGLISH LANGUAGE, DENMARK RESIDENCE, COPENHAGEN REGIDENCE~ GRANTOR DANISH STATE RES FOUND C][a 90 CEINI3 01029