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_ it_ .., ........ L. (- HK027004~ 30629 q,6,8 PATHOLOGY IN ANIMALS EXPOSED TO HIGH CONCENTRATIn.~IS OF CARBON MONOXIDE FOR SIX MONTHS PROC CONF ENVIRON TOXIC 0(0): 23-27~ 1970 MACKENZIE, WF/ PATRICK, RL, MONTELEONE, PN P.~: THIS STUDY EXAMINES THE HISTOPATHOLOGICAL EFFECTS OF LONG TERM EXPOSURES TO "HIGH" CONCENTRATIONS OF CARBON MONOXIDE (C0) IN SEVERALSPECIES OF ANIMALS. THE FIRST PART (~0628) OF THIS STUDY EXAMINED THE HEMATOLOGICAL EFFECTS OF C0. ~ETHOb.%: HISTOLOGICAL EXAMINATIONS WERE PERFORMED ON 68 RATS, 40 MICE, 2 BABOONS, 4 RHESUS MONKEYS, AND BEAGLE DOGS, EXPOSED TO 460 MG/M3 CO FOR 71 DAYS FOLLOWED BY 575 MG/M3 CO FOR 97 DAYS, AUTOP- SIES WERE PERFORMED ON MOST ANIMALS IMMEDIATELY FOLLOWING LAST EXPOSUREJ SEVERAL ANIMALS WERE HELD FOR ~ MONTHS FOR REVERSIBILITY STUDIES, FINDINGs: HISTOLOGICAL CHANGES HERE CONFINED TO RATS AND CON- SISTED OF AN INCREASE IN HEART AND SPLEEN WEIGHTS, HO ANATOMIC CHANGES HERE FOUND IN ANY OTHER SPECIES, THE ONLY MICROSCOPIC LESIONS FOUND WERE PULMONARY AND GASTROINTESTINAL EDEMA AND HEMORRHAGE IN TWO RATS WITH POSSIBLE CIRCULJ~TORY FAILURE, THE IMMEDIATE RESPONSE TO EXPOSURE IN ALL SPECIES WAS DEPRESSION OF ACTIVITY, BUT WITHIN A WEEK THE ANIMALS "APPEARED RELATIVELY NORMAL," DISCUSSlC)R: "BASED ON THE PATHOLOGIC STUDIES, IT IS INDICATED THAT CO HAS NO DIRECT EFFECT ON THE BODY THAT PRODUCES A DEGENERA- 'TIVE ANATOMIC CHANGE," "ALTHOUGH NO LESIONS ASSOCIATED WITH THE EXPOSURE HERE FOUND IN CIR 9~q CDHI3 O102_:~

i! HK0270042 • , .:t i 30629 THE DOGS, "1~0 INTERESTING DISEASES UNASSOCIATED WITH THE EXPOSURE WERE FOUND IN BOTH EXPOSED AND CONTROL ANIMALS, THE FIRST CAUSED SMALL GRANULOMATA WITHIN THE LUNG OCCASIONALLY CONTAINING THE DEBRIS OF A DEAD NEMATODE LARVA AND ALSO AREAS OF CHRONIC PERI- BRONCHITIS AND AREAS OF CHRONIC INTERSTITIAL PNEUMONITIS," THE SECOND DISEASE WAS SEVERE ORCHITIS, mTHE ANIMALS AT RISK IN THIS EXPERIMENT WERE YOUNG HEALTHY ADULTS IN THE CASE OF THE RODENTS AND DOGS AND HEALTHY ADOLESCENT PRIMATES, THEY ARE NOT REPRESENTATIVE OF THE HUMAN POPULATION AT RISK IN A • CIVILIAN COMMUNITY OR, FOR THAT MATTER, IN THE AIR FORCE AS A WHOLE, HOWEVERa IT DOES SEEM THAT THE BODY'S ABILITY TO ADJUST TO HIGH C0 LEVELS IS MUCH GREATER THAN HAD BEEN PREVIOUSLY SUSPECTED,,,'n /OM/ (PART OF A SERIES: SEE ALSO DOCUMENT # 30628) US AIR FORCE AER MED RES LAB, WRIGHT PATTERSON Am, OHInl LAB EXP BIOL, ST LOUIS, MO; JOHNST MEM HOSP, JOHNSTOWN, PA HISTOPATHOLOGICAL STUDY A, AUTOPSY STUDY A, RATS, MICE, BABOONS, MONKEYS, DOGS. PRIMATES, THOUSAND, CARBON MONOXIDE EXPOSURE A, HISTOLOGICAL FINDINGS Aj CHRONIC ADMINISTRATION A/ BEAGLE DOGS, RHESUS MONKEYS, CARBON MONOXIDE EXPOSURE DURATION A, PHYSICAL ACTIVITY DECREASE A, BEHAVIOR CHANGES CARBON MONOXIDE ASSOC A, ACCLIMATI7.ATION A, SKIN IRRITATION A, SURVIVAL RATE A, HEMATOLOGICAL CHANGES A, .Food CONSUMPTION DECREASE A, BLOOD VOLUME INCREASE A, BLOOD VISCOSITY INCREASE A, DATA COMPARABILITY A, SPECIES SUSCEPTIBILITY A, SPECIES DIFFERENCES A, HEART WEIGHT INCREASE A, SPLEEN WEIGHT INCREASE A, ANIMAL MODEL EXTRAPOLATION CONCESSION, ACCLIMATIZATION, CARBON MONOXIDE ADAPTATION, CARBON MONOXIDE EXPOSURE, CARBON MONOXIDE TOLERANCE, CTR 98 COH6 01026

• J • 1 i t HK0270043 r k 30629 CARBON RONOXIDE TOLERANCE A, LEFT VENTRICLE HYPERTROPHY A, PARASITIC INFESTATION A," BEAGLE STUDY HL LUNG GRANULOHA A~ PERI~RONCHITZS As PNEUMONITIS A/ PENTOBARB]~AL ANESTHESIA A, MICROSCOPY, LYMPHOSARCOMA A, HEART ENLARGEMENT A, ORGAN HEIGHT UNCHANGED As KIDNEY WEIGHT A, LIVER HEIGHT INCREASE A, NEUROLOGICAL DISTURBANCES A, ~ISTOLOGICAL EXAPIINAT|ON A, GASTROINTESTINAL HEMORRHAGE A, AORTIC LIP1D DEPOSITION A, NEMATODES/ ENGLISH LANGUAGE, WRIGHT PATTERSON AIR FORCE BASE ~HIO RESIDENCE, USA RESIDENCE, ST LOUIS MO RESIDENCEs JOHNSTOWN PA RESIDENCE £TR 98 COH6 0")02~~