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1 ,4 HK0270023 30628 6 HEMATOLOGICAL EFFECTS OF LONG-TERM CONTINUOUS'ANIMAL EXPOSURE TO CARBON MONOXIDE PROC CoNF ENVIRON TOXIC 0(0)" 7-22J 1970 VERNOT, EHI MACKENZIE, WF, MACEWEN, JD, MONTELEONE, PN, GEORGE, ME, CHIKOS, PM, BACK, KC, THOMAS, AA, HAUN, CC ~.U.Eg.O.~ THIS STUDY EX/V~INES THE HEHATOLOGICAL EFFECTS OF LONG-TERM CONTINUOUS EXPOSURE TO CARBON MONOXIDE INDOGS AND MONKEYS. THE SECOND PART OF THIS STUDY EXAMINES THE HISTOPATHOLOGICAL EFFECTS, ~.I BLOOD CARBON MONOXIDE, HEMOGLOBIN, HEMATOCRIT, OXYGEN DIS" SOCIATION CURVES~ AND OTHER HEMATOLOGICAL DATA WERE EVALUATED IN 42 RHESUS MONKEYS AND 32 DOGS EXPOSED TO CARBON MONOXIDE AT VARIOUS CON- CENTRATIONS (57,5-575 MG/M3) FOR VARIOUS LENGTHS OF EXPOSURE (100 DAYS - 13 WEEKS), FINDINGS: THERE WERE A SERIES OF MEASURABLE CHANGES RESULTING FROM THE DEVELOPMENT OF NORMOCYTICsNORMOCHROMIC POLYCYTHEMIA, BLOOD CAR- BON MONOXIDEe HEMOGLOBIN AND HEMATOCRIT INCREASED WITH INCREASING CARBON MONOXIDE CONCENTRATIONS~ THE RESPONSE IN MONKEYS WAS RELA- TIVELY GREATER THAN THAT OF THE DOGS, ~'," [NONE] (PART OF A SERIES= SEE ALSO DOCUMENT #30629) /O~V US AIR FORCE AER NED RES LAB, WRIGHT PATTERSON AFB, OHIO/ US AIR FORCE AER MED RES LAB, WRIGHT PATTERSON AFB, OHIO; JOHNST M~ HOSP, JOH~ISTOWN, PA CTR 98 COHG 01023

I HK0270024 30628 HEMATOLOGICAL STUDY A, INHALATION STUDY A, DOGS, MONKEYS, PRIMATES, HUNDRED, CARBON MONOXIDE EXPOSURE A, POLYCYTHEHIA A, HEHATOLOGICAL CHANGES A, BLOOD CARBON HONOXIDE INCREASE A/ BEAGLE DOGSs RHESUS MONKEYSs CHRONIC ADHINISTRATION As CARBON HONOXtDE EXPOSURE DURATION As HERATOCRIT INCREASE CARBON HONOXIDE ASSOC As HEHOGLOBIN INCREASE CARBON HONOXIDE ASSOC As ERYTHROCYTE INCREASE As SPECIES DIFFERENCES A, SPECIES SUSCEPTIBILITY A, ACCLIRATZZATION A, ~ETHODOLOGY CONCESSION A, BLOOD CARBON HONOXIDE SATURATION A, ARTERIAL OXYGEN TENSION DECREASE A, HEHOGLOBIN OXYGEN DISSOCIATION CURVE A, VENOUS OXYGEN TENSION As TISSUE OXYGEN CONSUHPTION A, CARBON HONOXIDE POSITIVE DOSE RESPONSE Aj CARBOXYHEMOGLOBIN A/ AIR CARBON HONOXIDE CONTENT A, RETICULOCYTE COUNT As BLOOD VOLUME INCREASE A, BLOOD VISCOSITY INCREASE A, PENTOBARBITAL ANESTHESIA A, LEUKOCYTE COUNT A, BLOOD CLOTTING A,'ERYTHROCYTE COUNT A~ STATISTICAL ANALYSIS~ BLOOD 2 3 DIPHOSPHOGLYCERATE A, CARBON MONOXIDE EXPOSURE, HEHOGLOBIN INCREASE, CONFINED SPACE ATHOSPHERE, INFRARED CARBON HONOXIDE ANALYZER/ ENGLISH LANGUAGE~ WRIGHT PATTERSON AIR FORCE BASE 0HIO RESIDENCE, USA RESIDENCE, JOHNSTOWN PA RESIDENCE, SEATTLE WASH RESIDENCEs CONFEREN˘:E • -].~ C]R .gB COI,IB OIL ~.~