Tobacco Documents Online

I =" HK027000t ( Cortez, ~'on Ton.'Lcco ~Es~-=,no~--'I3".S..A... L,,'o. .110 ,leAST DOT~ ST~'0~"I" 1%"J~Ir T01~, I~. T. ].0022 I~,00~ 8os .s .S, D. I. PROFILE (SetecIlve Dissemi~atLon of I-~ormar~ou) Name: ('P~ot~,..,.--t" C... Profile: " "~a.l.t~'v,' ~w.,,. r)ate of Rum Resu3ts: .... //.~ ?'~.s3 3o(,2-1 31~oo 3 s"~ .2 ~" Z&789 370#3 37089 3 7:, r'). 7~& 7~'~ 7~'~" 3 77/o 3 79 ~st CTR 9B CONL3 01016

. ~ HK0270002 "27283 5,7 RELATIVE AFFINITY OF HUMAN FETAL H~IOGLOBIR FOR CARBON MONOXIDE AND OXYGEN BLOOD 33(i): 37-45; 1969 ENGEL, RR/ RODKEY, FL, 0'NEAL, JD, COLLISON, HA/ BERK, P, ERLANDSON, ME, LEIKIN, SL, FELD, M PURPOSE: THE RATIO OF CARBON MONOXIDE (C0) TO OXYGEN BOUND BY ADULT HEMOGLOBIN IS 217 TIMES GREATER THAN THE RATIO OF THESE GAS TENSIONS. IN AN EQUILIBRIUM MEDIUM, ALTHOUGH THE STRUCTURE OF ADULT AND FETAL HEMOGLOBIN ARE WELL DEFINED~ THE RELATIVE CO AFFINITY OF FETAL HEMO- GLOBIN HAS NOT BEEN INVESTIGATED, THIS STUDY DETERMINED FETAL HEMO- GLOBIN CO AND OXYGEN BINDING VALUES, ~ETHOD~: SAMPLES OF MATERNAL, FETAL, AND PLACENTAL BLOOD WERE OB- TAINED FROM 15 PATIENTS UNDERGOING CAESAREAN SECTION, AN EQUILIBRA- TION METHOD WAS USED TO MEASURE CO AND OXYGEN UPTAK~ AND THE RELATI[VE AFFINITY CONSTANT OF HEMOGLOBIN WAS CALCULATED, ~: FETAL AND PLACENTAL BLOOD HAD A 20% LOWER RELATIVE AFFI-' NITY FOR CO THAN ADULT (MATERNAL) BLOOD: I,E,J FETAL HEMOGLOBIN HAD LESS PREFERENTIAL BINDING OF CO OVER OXYGEN THAN ADULT HEMOGLOBIN, BY CORRECTING FOR THE FRACTION OF ADULT HEMOGLOBIN IN PLACENTAL BLOOD IT WAS CALCULATED THAT FETAL HEMOGLOBIN HAS A RELATIVE AFFINITY CON- STANT OF 172 ± 12, DISCUSSION: BECAUSE OF THE DIFFERENCE BETWEEN ADULT AND FETAL HEMO- GLOBIN, "THE DIFFUSION GRADIENT FOR C0 ACROSS THE PLACENTA CAN NOT BE EQUATED WITH THE DIFFERENCE IN CARBOXYHEMOGLOBIN PER CENT SATURATION (COHB), THIS RELATIONSHIP IS OF INTEREST WHEN COMPARISONS ARE MADE BETWEEN MATERNAL AND FETAL COHB LEVELS TO DETERMINE THE DIRECTION OF CO TRANSFER. SUCH COMPARISONS ARE PERTINENT WHEN CO IS USED TO EVAL- CTR 98 COI'IG 0101?

J . HK0270003 '27283 UATE PLACENTAL FUNCTION, AND HHEN CO IS IMPLICATED AS MEDIATING AN ADVERSE EFFECT ON THE FETUS FROM MATERNAL SMOKING,., "[TJHE PRESENT FINDING OF A LOWER RELATIVE AFFINITY BETWEEN CO AND FETAL HEMOGLOBIN COULD NOT HAVE BEEN PREDICTED FROM THE FACT THAT' THE TWO HEMOGLOBINS DIFFER SIMPLY" IN THEIR STRUCTURE. "THE LOWER RELATIVE C0 AFFINITY OF FETAL HEMOGLOBIN APPEARS TO BE INCONSEQUENTIAL IN MAINTAINING NORMAL INTRA-UTERINE HOMEOSTASIS, EVEN IN THE RARE CASE OF CO POISONING DURING PREGNANCY THE FETUS WILL USU- ALLY SUCCUMB OR INCUR PERMANENT BRAIN DAMAGE BEFORE THE HOTHER," /GSD/ U MINN SCH t'IED, MINNEAPOLIS, MINN/ US NAV MED RES I, BETHESDA, rqD ANALYTICAL STUDY, METHODOLOGY STUDY, HEMATOLOGICAL STUDY, CLINICAL STUDY~ HEMATOLOGICAL DATA, CLINICAL DATA, FEMALE DATA, MATERNAL DATA, HUNDRED, BLOOD CARBON MONOXIDE ANALYSIS, BLOOD CARBON MONOXIDE UPTAKE!, BLOOD CARBON MONOXIDE CONTENT, BLOOD CARBON MONOXIDE CHANGES, BLOOD CARBON MONOXIDE AGE FACTORS ASSOC, HEMOGLOBIN OXYGEN AFFINITY CHANGES, FETAL HEMOGLOBIN/ FETAL BLOOD CARBON MONOXIDE MATERNAL SMOKING CAUSATION 2, FETAL DEVELOPMENT, FETAL BLOOD SUPPLY, TOBACCO SMOKING, FEMALE SMOKING HABITS, SMOKING REPRODUCTIVE SYSTEM EFFECTS, BLOOD CARBON MONOXIDE MECHANISMS, BLOOD CARBON MONOXIDE SATURATION, BLOOD CARBON MONOXIDE TENSION, HEMOGLOBIN CHANGES~ HEMOGLOBIN STRUCTUREj HEMOGLOBIN OXYGEN DISSOCIATION~ HEMOGLOBIN OXYGEN SATURATION, HEMOGLOBIN BIOCHEMISTRY, CARBOXYHEMOGLOBIN, 0XYHEMOGLOBIN, HATERNAL BLOOD, PLACENTA BLOOD FLOW, PLACENTA PERMEABILITY, PLACENTAL TRANSFER~ INFANT BLOOD, FETAL HYPOXIAs CARBON MOHOXIDE TOXICITY, CARBON MONOXIDE SUSCEPTIBILITY, IN UTERO TRANSMISSION, HOMEOSTASIS, ANALYTICAL METHODS VALIDITY, EXPERIMENTAL METHODS CONCESSION, METHODOLOGY E:]-~ cIB COHG O101El

HK0270004 27283 VALIDITY, METHODOLOGY CONCESSIONj EXPERIMENTAL DATA EXTRAPOLATION HI, DATA COMPARA31LITY, HEMATOLOGICAL CHAN6ES/ HEHOGL, OBIN DETERMINATION, CESAREAN SECTION, BLOOD TRANSFUSIONS, THALASSEMIA, BLOOD PH CHANGESa HEMOLYSIS, ~RAIN DAHAGE, TEMPERATURE FACTORS, BLOOD CARBON MONOXIDE A, DOGS, RATS, HEMATOLOGICAL EXAHINATION/ ENGLISH LANGUAGE, BETHESDA ND RESIDENCE, MINNEAPOLIS NINN RESIDENCE, USA RESIDENCE, GRANTOR US NAVY BUR NED SURG, OBSTETRICAL PATIENTS, INFANTS, FETUS, CHILDREN C~R .90 CL%II3 01019