Bliley Brown & Williamson
Confidential Work Product Prepared by Outside Researchers at the Request of Counsel for the Tobacco Institute, with Whom B&W Maintains A Common Legal Interest, and Forwarded to B&W in-House Counsel, B&W Management and Various Other Industry Management, with Whom B&W Maintains A Common Legal Interest, Providing Information Regarding the Saftey Assessment of Ingredients Added to Tobacco
Fields
- Type
- REPORT
- Author
- Doull, J.
- Frawley, J.
- George, W.
- Loomis, T.
- Squire, R.
- Recipient
- Covington & Burling
- Copied
- Wells, John Kendrick, III (BW, Assistant General Counsel)In a 1/17/85 memo, BWT corporate counsel J. Kendrick Wells said he had advised Earl Kornhorst, BWT's VP for research, development and engineering, on the need to prune scientific reports from his files. Wells marked certain reports with an X to designate those that were "deadwood in the behavioral and biological studies area". The Janus studies--secret program of biological research on the effects of smoking which showed tumor growth in animals--should be treated as "deadwood". These documents should be segregated, boxed and put in the basement for possible shipment to BAT Industries in England, but no one "should make any notes, memos or lists of the documents" (LAT 8/2/94).
- Anders, J.
- Appleton, S.
- Blixit, C.
- Carchman, R.
- Daylor, F.
- Dietz, D.
- Spears, A.
- Suber, R.
Document Images
.q SAFETY A.qS£SSMENT OF
Jo~u~ Doull, Ph.D., M.D.
John ~. Fm&wley,
William George, Ph.D.
Te~ L~mls
Ro~er', A. Squire, Ph.D., D.V.M.
Detester 199~
~-5~'703565
PRIVILEGED AND CONFIDENTIAL -- Produced as lequ~[ed by lhe C()ur! s March 7, 19980~del~n
The Sidle of MJ.Itesolo el ~1 v Phd~p Mo.~.s. el al Court File No C 1 94 8565 IIs use ~s sublet! Io
Ihe Protective Order ~n t/lal case
Mill~lusola Tobacco 1 itigalio~: B&W PrivilegedlP~otectu(lll~) CameCa Materials
---
- 2 -
commonly added ~o clqarec:e ~obacco is vanillln.
The au:hurs of :hAS =epor~, whose qua!IflCa:~ns are
Ingredlen~s.
The ~a~e~la! examined was ex~ensiv~, and !nclude~
summar7 ~a~a of all :elevanu published and unpublished
levels, an~ annual ;aundage ~a~a for ~he Ing~edlen~s were also
evalua~a~. Each sclen~Is~ independently vlsi~ed u~e
o
were ~ade available a~d were examlne~ as nec~ssa~I, an~ e~c~
E52703565
- ] -
App~ox~ma~e~ ~4~ o~ all
clgarem:e mobecco An ~e United S~a~es
Recogni:e~ As Sa~e" ~G~S~ ~ m~e ~A
leaf mo~acco ccmpcnen:s. T~e pym~iysls pm~duc~s of such
ore: one-~hlr~ oc=u: a~ levels ~elow 1
T~e au~ho:s :ev:ewe~ ex:ensive ~a~a on ~e
u~uOl~s~e~ s~u~les ...c..d~ ~c~g :.~ese
- 4 -
f:o~ ~.~ v_.i~'.o aria ~n v_.Ivo tests on me~abol£sm, ~eno=ox~ci~
envA:or~en~al c~emAcals. The ob~e¢%~ves o~ ~ese s~udies are
~e~e.-m.i~e ~e exposure :eve~s e~ ~hic~ adverse e~ec=s ~a~ occur
a~!nls:ered, and they also may vary among species. Such
Inform. a~ion is, :~erofore, of%en essential for ~ete~Inlng
levels o~ h~n exposure.
6S2703570
o ;o
cigarette tobacco have included skin painting, £nhalat!on, end
and fetal and neonatal development.
in~redlen~s added ~o clgaret%e ~obacco, emphas~s was g~ven ~o
pro~r!e~a~f-flavor fo~ulatlons, and exposure, If any, woui~ ~e
to~icol~glcally Insigniflcan%. Exp~sur~ :o many of %hess flavor
Ai:hough all :'~es of :ox/colOglca! da~a have some
- 5 o
ci~a=e~e ~'~bacco, parmlcu~a=~¥ =elevanm ace inhalamlon s~udies
Anvo~vlng actual smoking experiments An animals which compare
smo~e ~om bu~nin~ cigarettes ~o~ exmende~ periods, and mox~-
~:~acco have nom ~een obse~ed ~o induce adverse e~ec~s in
:~ese experlmen~s. :n ~ac~, in ~any cases added In~=eClen:s
- 7
ne~a:ive.
8ase~ upon analyses o! aA4 o5 ~e ~ox!coloqical data
~ols:ure, ad~ ~avo:, and reduce "~am" an~
~n ~e United $~a~es. ~os~ are presenm
addA~Ave-~ee
has ena~oled~nu~ac~umems ~o d~velop
and nlco~ine yAel~s ~an ~oul~ o~e~ise ~e avaiL-
C _~2'703~73
- 8 -
h~es~ levels Ln ¢~a~e~=es occu~ a~ ~evels =anq~nq f=om 0.05~
to i~.Sa~ by weAght. These ~ng~e~£ents, along wash p~ocessAng
tobac=o in the ~anu~acmu~e o~ clgaret~e$, and have been exten-
slvel~ ~esme~ ~oc salem,. All cemalnln~ In~edlents occu~ a~
~=ou~ smoking.
The au~=~ o~ ~4s re,or% independently examined
and ~ound none Co ~e ~omenmlall~ ~oxlc au levels of use.
In :~e ~anu~acmume o~ c!~a=e~:es by Unlmed S~a~es ~anu~ac~umers
a=e no~ ~azard~s under ~he conditions o~ use.
