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LAW OFFICES SHOOK, HARDY & BACON TWENTIETH FLOOR MERCANTILE BANK TOWER I101 WALNUT KANSAS CITY, MISSOURI 64106 (816) 474-6550 OVERLAND PARK, KANSAS OFFICE 40 CORPORATE WOODS, SUITE 650 INDIAN CREEK PARKWAY P. O. BOX 25128 (913) 383-3555 February 8, 1985 Arnold Henson I..._~ Alexander Holtzman ~.÷Josiah S. Murray III Ernest Pepples ~ Arthur J. Stevens B. Witt Gentlemen: For the past five years, Dr. Domingo Aviado has received a Special Fund 4 grant in support of his consulting activities in the smoking and health area In 1984, the amount of the grant was $102,000 for professional time and expenses. We recommend that Dr. Aviado be given support in 1985 in the same amount ($102,000) to be funded again through Special Fund 4. - " • As ~n previous" years, Dr. Av~ado" has performed consultancy work through a professional corporat on named Atmospheric Health Sciences, Inc. During 1984, he devoted approximately 204 days of the working year to projects related to smoking and health. These projects included his ongoing review of generally relevant literature, special reviews of literature relating to bronchogenic carcinoma, environmental carcinogenesis and pulmonary metastases, analysis of environmental tobacco smoke materials and preparation of related critiques, attendance at various scientific meetings, -work on the smoking aboard aircraft issue and participation at a CAB hearing, and analysis of studies involving atherosclerosis and smoking behavior. Dr. Aviado has been especially busy in the last few months working with the newly formed industry committee on environmental tobacco smoke. Dr. Aviado continued his informal association with the EPA Clean Air Advisory Committee and other governmental groups. Such work, along with his occasional consultation with chemical, and pharmaceutical companies, made Dr. Aviado a valuable source

SHOOK, HARDY ~, BACON February 8, 1985 Page Two of information for us. He also continues to be helpful in identifying possible medical consultants in the New Jersey area. During 1984, Dr. Aviado was very active in the American College of Clinical Pharmacology and served as interim Editor of the Journal of Clinical Pharmacology for part of the year. He also maintained his status as a well known scientist by publish- ing several papers and co-editing a medical textbook. We have reviewed Dr. Aviado's activities for 1984 and feel that renewed support is warranted. As in previous years, we will review the grant at the end of the year to determine a similar consulting arrangement is advisable for 1986. An response to this recommendation would be appreciated. ~ ~-. .... ~ PMS:sh cc: Ms. Janet C. Brown Mr. Edwin J. Jacob Mr. Francis K. Decker, Jr. Sincerely, Patrick M. Sirridge