Tobacco Documents Online

Researcher Project Title/ Description CTR Special Projects Period John R. Carter Autopsy study designed to examine accuracy of lung cancer diagnoses (Investigators checking autopsy ~records of University Hospitals for period extending from 1948 to 1974 for errors in diagnoses) Final report accepted for publication by Cancer (not yet published) June 30, 1980 ' (Personal & Confidential--. For Counsel Only) Budget $86,305; addition- al $5,780 approved 8-29-77 to locate and analyze past medical histories of patients who died early in pro- ject Date Approved June, 1974 H. J. Eysenck Maintenance of Twin Registry 2 years (Through 4-80) $30,000 total; $6,600 for cost overruns March, 1978 July, 1977 Alvan R. Feinstein Support biostatistician to assist Dr. Feinstein 2 years $50,000 June, 1976 [In abeyance until selection made] Franklin Institute Determination and characterization of tobacco glycoprotein as an artifact 2 months $20,130 May, 1979 Generation of 25 milligrams of artifact $7,700 , September, 1979 Research satis- factorily com- pleted 1-80 $2,300 for cost overruns January, 1980

Researcher Arthur Furst Project Title/ Description CTR Special Pro~ect~ Period Study the Effects of Combined Asbestos and Benzo(a)pyrene on lungs of mice 2 years; data currently being analyzed Budget $61,500 $3,000 additional for increased cost of slides Date Approved March, 1977 December, 1979 Richard Hickey "Epidemiological and Etiological Studies on the Relation of Air Pollution, Smoking and Other Environmental Variables to Human Chronic Diseases" 1-1-80 to $80,G36 12-31-80 Letter of confir~.~ tion from CTR for extension of project dated 3-20-80 Duncan Hutcheon "A Pilot Project to Investigate the Environmental Pharmacology of Industrial Inhalants" 1 year $89,870 4 month $35,000 extension April, 1979 Pending Joe Janis Suzanne Knoebel Statistical model of lung cancer mortality Through summer, $6,000 1979 Extension through $6,800 10-31-80 Determine reliability of non- invasive technique to measure changes in cardiac function, if any, during inhalation of tobacco smoke 1 year; preliminary $23,825 report dated 7-79 February, 1979 May, 1980 December, 1977

Researcher Mariano La Via Project Title/ Description CTR Speclal Projects Period Support for graduate student to assist in basic research in field of immunopathology 2 years; Assistant selected July, 1978 Budget $24,000 Date Approved Letters of approval dated April, 19787 letter of confirma- tion from CTR dated 9-11-78 Thomas F. Mancuso ~ "Demographic Studies of Mortality in Ohio" (Step-by-step progression of identification of high risk pop- ulation sub-groups and attempts to determine specific causes for high risk) 14 months (said he plans to write report this summer.) $38,700 October, 1975; July of 1976 re- quested 12-montl~ extension without additional funds for completion of work Low level radiation study $10,000 March, 1979 Eleanor Macdonald "Regional Patterns of Cancer of 1 year; $106,443 Major Sites in 5 Large Regions of Texas & Regional Patterns of Mortal- ity in Houston, 1940-1969: (Study of 5-1-80 through $123,121 factors associated with high cancer 4-30-81 rates in states or regions of U.S.) Extension approved February, 1979 Extension approved May, 1980 Funds to cover costs of retirement program as required by new Texas law $2,916 . October, 1979 Kenneth Moser Investigation of Potential Role of 3 years Polymorphonuclear Leucocyte Elastase Concentration in Pathogenesis of Emphysema Total projected cost from $198,000 to $212,000 December, 1976

ill I Researcher Ingram Olkin Project Title/ Description CTR S~ecial Pro~ects Period "A Study of the Models Used in the Analysis of Certain Medical Data" (Review of the appropriateness of treating biomedical data with the multivariate techniques of assumed ~normality) 2 years Final report sent to CTR on 7/6/79, and report for publi- cation in progress Budget $12,000 Date Approved Letter of confirma- tion from CTR dated 4-19-76 Charles Puglia/ Jay Roberts "Adaptation to Components of Tobacco ,Smoke" (a study of the response of the lung to oxidants contained in cigarette smoke; adaptation of the heart to nicotinic effects) I year; 6 month extension obtained from CTR with no increase in funding $44,014 May, 1979 Henry Rothschild Henry Russek/ Second extension of pilot study exam- ining disproportionately high mortal- ity rates of respiratory tract cancer in southern Louisiana to determine if genetic and environmental factors are possible causes (Rigdon helping) Extension includes an investigation of respiratory cancer and employment in sugar cane industry 1 year $35,251 "Behavior Patterns and Strategies for 12-18 months $48,500 June, 1979 December, 1979 Linda Russek the Mastery of Stress, Anxiety Re- duction and Perceptual Functioning" (a comparison of the efficacy of different methods of relaxation in the face of stress; a study of dif- ferences between Type A and Type. B individuals)

Researcher John Salvaggio Project Title/ Description CTR Special Projects Period Budget Investigation of Physical, Chemical and Immuno-Chemical Properties of Components Present in Tobacco Smoke 4 years First year received $59,450; 6-1-76 requested increase in second year budget from $34,385 to $43,101 and in third year from $37,030 to $52,325; fourth year budget is $63,146 fifth year budget is $65,755 Date Approved May, 1976 Increase in funding approved May, 1977 4th year approved May, 1979 May, 1980 Carl Seltzer Continuation of work on constitu- tional differences between smokers and nonsmokers 7-1-79 through 6-30-80 7-I-80. through 6-30-81 $70,000 $70,000 April, 1979 April, 1980 Theodor Sterling "A Continuing Critical Review of the Major Factors in the Etiology of Diseases Emerging from Statisti- cal Studies" 7-i-77 through 6-30-80 Extension to 5-30-81 $610,000 $283,130 Letters of appr~ dated March-ApriI~, 1977 March, 1980

CTR Special Projects Researcher Project Title/ Description Period Theodor Sterling "Computer Analysis of Health-Related Data" (Modification of funding pro- cedure in main project designed to conform with governmental requirement ~hat university facility cannot be used for nonuniversity projects) Date Budget Approved No change in cost of project (14% of project budget Procedural change approved September, 1977, to begin allocated to Simon 10-1-77 Fraser University, remainder to orig- inal grantee) "Evaluation of the Interaction Between Geographic, Geocultural, Smoking and Health Variables and Indices" 18 months $54,710 September, 1979 Theodor Sterling/ Harold Perry "Retrospective Analysis of Environmental Contacts of Patients with Respiratory Cancer, Other Cancers, and Other Diseases" 2 years $127,932 $17,634 additional Letters of approval dated October, 1978 November, 1979