Tobacco Documents Online

References i. Benowitz NL, Hall SM, Herning RI, Jacob III P, Jones RT, - OsmanAL ~ Smokers of low-yield cigarettes do not consume less nicotine. N Engl J Med 1983b; 309:139-142 2. Armitage AK Some recent abservations relating to the absorption of nicotine from tobacco smoke. In: Dunn WL, ed. Smoking behavior: Motives and incentives. Washington DC: Winston, 1973:83-91 3. Rosenberg J, Benowitz NL, Jacob P, Wilson KM Disposition kinetics and effects of intravenous nicotine. Clin Pharmacol Therap 1980; 28:517-522 4. Beckett AH, Gorrod JW, Jenner P The effect of smoking on nicotine metabolism in vivo in man. J Pharm Pharmacol 1971; 23 (Suppl.): 62S-67S 5. Benowitz NL, Knyt F, Jacob III P, Jones RT, Osman AL Cotinine disposition and effects Clin Pharmacol Ther 1983; 34:604-611 ii

6. Gori GB, Lyich CL Smokers intake from cigarettes in the l-mg Federal Trade Commission tar class. - Regulatory Toxicol Pharmacol 1983; 110-120 7. Gritz ER, Baer-Weiss V, Benowitz NL, Van Vunakis H, Jarvik ME Plasma nicotine and cotinine concentrations in habitual smoke- less tobacco users. Clin Pharmacol Ther 1981; 30:201-209 8. Matsukura S, Sakamoto N, Seino Y, Tamada T, Matsuyama H, Muranaka H Cotinine excretion and daily cigarette smoking in habituated smokers. Clin Pharmacol Ther 1979; 25:555-561 12

Table 1 Mean steady state concentration of cotinine in plasma during the last dosing interval on the fourth day (ug/liter) Dose of nicotine in ug/kg/day (in ug/kg per injection) No 1 No 2 No 3 No 4 No' 5 No 6 120 (5) 79.15 118.08 109.33 85.08 71.08 89.50 240 (10) 168.33 204.75 192.33 195.75 167.42 182.00 360 (15) 240.92 276.41 292.33 314.83 249.42 291.00 480 (20) 407.25 413.16 415.00 376.58 311.67 360.75 X (SD) 92.04 (18.1) 185.1 (15.2) 277.49 (28) 380.74 (40.29) 90 UO [O

Table II ~ Mean nicotine content of three different brand of cigarettes using data colle~ted by Gori and ~Lynch (6) and our/~e~ I. :otinine level ng/ml Cigarettes per day • FTC rating Mean nicotine per c~garette mg Ratio to C Brand A B C 301 204 29.0 30.5 0.18 0.861 0.Ii 0.55 1.57 1.01 208 31.5 0.i0 0.548 1.0

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Table II Mean nicotine content of three different brand of cigarettes using data colle ted by Gori and Lynch (6) and our ~ i. Brand Cotinine level ng/ml Cigarettes per day A B C 301 204 208 29.0 30.5 31.5 FTC rating .. 0.18 0.ii 0.I0 Mean nicotine per cigarette mg 0.861 0.55 0.548 Ratio to C 1.57 1.01 1.0