BATCo
1996-1997 Research Agenda - Request for Applications
Fields
- Named Organization
- World Health Organization
- University of Minnesota
- University of Lisbon
- NYU Medical Center
- Concordia University
- University of Vermont
- Colorado State University
- University of Pittsburgh
- University of Gothenburg
- San Diego State University
- University of Missouri-Rolla
- University of Tulsa
- Wake Forest University
- University of Toledo
- Tufts University
- US Public Health Service
- National Institute of Standards and Technology
- Virginia Commonwealth University
- US FDA
- University of Washington
- University of Illinois
- Philip Morris USA
- Brown & Williamson Tobacco Corporation
- Japan Tobacco Incorporated
- US EPA
- Meharry Medical College
- Oak Ridge National Laboratory
- US Department of Energy
- TRC Environmental Corporation
- Washington University
- Campbell University
- Danish National Institute of Occupational Health
- Penn State University
- Science Advisory Board
- Svenska Tobaks AB
- Ecusta
- Texas A&M University
- Meckler Engineers Group
- University of Arkansas for Medical Sciences
- University of Aarhus
- Proctor & Gamble
- Ford Motor Company
- Virginia Polytechnic Institute
- NIEHS
- Standard Commercial Corporation
- Shorewood Packaging
- Pennsylvania State University, The
- University of Mysore
- University of Tennessee, The
- DIMON International
- Cornell University Medical Centre
- New York University Medical Centre
- Ottawa
- Mead Paper
- Mundet International Limited
- Quest International Flavors USA
- Somerville Packaging Corporation
- United Technologies Carrier Corporation
- Gas Research Institute
- Touro College
- United Technologies Research Centre
- ITRI
- University of Alaska Fairbanks
- Dorgan Associates
- NYU Medical Centre
- ICF Kaiser Engineers Incorporated
- National Medical Advisory Service Incorporated
- University of North Arizona
- Synesthetics Incorporated
- Apex Environmental Incorporated
- Tulane University Medical Centre
- Rexair Incorporated
- Battelle
- St Louis University
- Building Science Corporation
- IRC Canada
- University of Denvar
- Johnston Controls Incorporated
- National Centre for Occupational Health South Africa
- Prairie Swine Centre Incorporated
- Health Effects Institute, The
- University of Kentucky
- University of California
- University of Texas
- University of Reading
- Southern Illinois University
- RJ Reynolds Tobacco GmbH
- University of Maryland
- Johns Hopkins School of Hygiene and Public Health
- Illinois Institute of Technology
- Brookhaven National Laboratory
- Virginia Polytechnic Institute and State University
- Universal Corporation
- Lorillard Corporation
- Utah State University
- American Health Foundation
- Harvard School of Public Health
- University of Wisconsin Hospital
- Ohio State University
- University of Maryland School of Medicine
- Boston University School of Public Health
- Jacksonville University
- National Institute of Health Guidelines Committee
- Northeastern University
- University of North Carolina
- University of Minnesota
- Named Person
- Lebowitz, Michael D
- Woods, James E
- Levetin, Estelle
- Eisenberg, Max
- Kessler, Irving
- Matanoski, Genevieve M
- Utell, Mark J
- Wolf, Alfred P
- Adams, Eric W
- Arora, Sanjay
- Aust, Steven D
- Bascom, Rebecca
- Bell, Iris R
- Benjaminson, MA
- Billick, Irwin H
- Blumenthal, Malcolm N
- Brennan, Terry
- Burleson, Gary R
- Burrell, Robert
- Cheek, Jeffrey
- Chen, Qingyan
- Croome, Derek J
- Crouse, William E
- Cain, William S
- Das, Salil K
- Delumyea, R Del
- Dorgan, Charles
- Dowell, Russell T
- Driscoll, Kevin
- Dunn, Bonnie
- Evans, Hugh L
- Fales, Henry M
- Frampton, Mark W
- Larson, Susan M
- Francis, Bettina M
- Gardner, Donald
- Last, Jerold A
- Gearhart, Jeffrey
- Getchell, Thomas V
- Giardino, Nicholas J
- Giese, Roger
- Gilbert, Stephen L
- Hedge, Alan
- Lehrer, Samuel B
- Glicksman, Leon R
- Ford, Timothy
- Jenkins, Roger A
- Gong, Henry
- Meckler, Milton
- Gordon, Terry
- Greene, Robert
- Haghighat, Fariborz
- Hajjar, David
- Hasselblad, Victor
- Hemenway, David
- Reif, John
- Roboz, John
- Rogers, John M
- Sen, Mihir
- Sharma, Vinod Kumar
- Silver, Wayne
- Smith, Douglas A
- Stoner, Gary D
- Stuart, Bruce
- Temple, Robert W
- Turner, Simon
- Tyler, Walter S
- Ultman, James
- Wallace, Lance
- Wispe, John
- Yager, James
- Yang, Chin S
- Zhang, Yuanhui
- Guerin, Michael R
- Lewis, Roger
- Lippman, Morton
- Witschi, Hanspeter
- Kilpatrick, James
- Akland, Gerald
- Burge, Harriet
- Bush, Robert
- Djordjevic, Mirjana
- Dockery, Douglas W
- Doty, Richard L
- Hoidal, John R
- Johnting, Jennifer
- Kanarek, Marty S
- Kleeberger, Steven R
- Kleinman, Michael T
- Knutson, Earl
- Kuhlman, Michael R
- Lewis, Robert
- Loyalka, Sudarshan K
- McGrath, James J
- Mennear, John H
- Nielson, Gunnar
- Ogden, Michael
- Otto, David
- Rohde, Charles
- Spannhake, E William
- Valberg, Peter
- Moschandreas, Demetrios
- Arey, Janet
- Hoffman, Dietrich
- Bohanon, Hoy
- Nagda, Niren L
- Brunnemann, Klaus
- Kilpatrick, S James
- Camboni, Silvana
- Klinger, Lorry A
- Menzel, Daniel
- Palmer, Kenneth C
- Potter, William T
- Ramsey, J Michael
- Stedman, Donald H
- Benson, Janet
- Baker, AJ
- Castagnoli, Neal
- Costa, Daniel L
- Rood, Mark J
- Lacey, John
- Leith, David
- Bement, Collette L
- Boyse, William K
- Christianson, Leslie L
- Cosma, Greg
- Costa, Lucio G
- Cunningham, Jennifer B
- Dharamsi, Amin
- Duffy, Lawrence K
- Eastmond, David A
- Fang, Jin Bao
- Gatley, John
- Gilbert, Avery Nelson
- Gilmour, Matthew Ian
- Gornes, Joao FP
- Goud, S Niranjan
- Graham, Charles W
- Grinsh, Sergey A
- Hittle, Doug C
- Holbrook, G Thomas
- Horner, W Elliott
- Hung, Ling-Ling
- Inyang, Hilary I
- Keller, John G
- Kjaergaard, Soren
- Koch, Wendy H
- Lehnert, Bruce
- Linn, Bill
- Lorig, Tyler S
- Madhusudhan, B
- Koller, Loren
- Koutrakis, Petros
- Nishimoto, Marc
- O'Callaghan, Michael W
- O'Neil, Carol
- Otten, James
- Ritter, Gary L
- Saman, Namir
- Samini, Behzad S
- Ryan, Lisa
- Smith, Raymond A
- Sauer, Hary J
- Sawnor, Marcia
- Solornon, Jerome J
- Swift, David L
- van Berkel, Gary
- Yousefi, Vali
- Zannetti, Paolo
- Zelikoff, Judiath T
- Woods, James E
- Notes
Author name is not available in the document Missing originals: 800105409-800106141. Handwritten.
- UCSF Code
- hle51a99
- Type
- agenda
- table
- Region
- United Kingdom
- China
- Sweden
- Canada
- South Africa
- China
- Date Loaded
- 01 Dec 2004
- Box
- 0161
- Folder
- bcmn0000
Document Images
-t
CENTER FOR INDOOR AIR RESEARCH
1996-t997
RESEARCH
AGENDA
REQUEST FOR
APPLICATIONS
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BATCo US DOJ v Philip Morris
Mission Statement
The mission of the Center for Indoor Air Research is to sponsor high quality
research on indoor air issues and to facilitate communication of research findings
to the broad .scientific community.
Science Advisory Board Members
William S. Cain, Ph.D.
Professor, Department of Surgery (Otolaryngology)
University of Califomia, San Diego
Michael R. Guerin, Ph.D.
Head, Organic Chemistry Section
Analytical Chemistry Division
Oak Ridge National Laboratory
Irving Kessler, M.D., Dr.P.H.
Professor, Department of Epidemiology and Preventive Medicine
University of Maryland School of Medicine
Morton Lippmann, Ph.D.
Vice-Chairman, Department of Environmental Medicine
New York University Medical Center
Genevieve M. MatanOski, M.D., Dr.P.H.
Professor, Department of Epidemiology
Johns Hopkins School of Hygiene and Public Health
Demelrios Moschandreas, Ph.D.
Professor, Pritzker Department of Environmental Engineering
Illinois Institute of Technology
Mark J. Utell, M.D.
Professor, Medicine and Toxicology
University of Rochester School of Medicine
Alfred P. Wolf, Ph.D.
Director, Cyclotron - PET Program
Brookhaven National Laboratory
James E. Woods, Jr., Ph.D., P.E.
Professor, College of Architecture and Urban Studies
Virginia Polytechnic Institute and State University
t3ATCo US DOJ v Philip Morris
J~uary, 1996
Dear Investigator:
I am plsased to provide you th~ Center for Indoor Air Research's "Request for
Applications" booklet. This package includes information about the Center,
the research and review process, procedures for application, the contract man-
agement process and the application forms. Also included is our Research
Agenda which describes CIAR's research interests.
Applications must be postmarked by June 1st. Funding of awarded projects
begins the following January I st.
If you have additional questions concerning application procedures, please
contact the Center at (410) 684-3777,
Thank you for your interest.
Sincerely,
"°" J
Bg~Co US DO
Table of Contents
Research and Review Process
.................................................................................. 3
Research Agenda
....................................................................................................
... 5
Application Process
................................................................................................. 10
Management of Research Contracts
....................................................................... 10
Contract Administration Policy
.............................................................................. 11
Application - General Information and Instructions ............................................. 12
Application Forms
.......................................................................................... FI - F3
Appendix A: CIAR Membership
........................................................................... 15
Appendix B: CIAR Peer Reviewers
....................................................................... 17
Appendix C: CIAR Final Report Guidelines .........................................................
25
Acknowledgements
................................................................................................. 26
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Center for Indoor
Air Research
The Center for Indoor Air Research
(CIAR) is a non-profit corporation
fonmed in March, 1988 to sponsor
high quality research on indoor air
issues and to facilitate communication
of research findings to the broad scien-
tific community.
The Center has three classes of mem-
bership: charter members, regular
members and associate members (See
Appendix A). The charter members
are those corporations that established
the Center and are currently providing
the majority of the funding. Regular
and associate members are those per-
sons or corporations that are interested
in indoor air quality research but were
not involved in the establishment of
the Center. The regular members are
represented on the Board of Directors
while the associate members are not.
The Center is actively seeking addi-
tional members in both the regular
and associate categories. Additional
information on membership can be
obtained by contacting the Center.
The Center has established a Science
Advisory Board (SAB) which develops
the research agenda for approval by
the Board of Directors. The SAB
recommends proposals for funding
after they have been peer reviewed by
the Center's pool of peer reviewers.
This structure ensures that only high
quality research which will contribute
to the knowledge bank on indoor air is
recommended for funding.
Research and
Review Process
The research agenda of the Center for
Indoor Air Research is formulated by
the Science Advisory Board (SAB), a
multi-disciplinary group of individuals
with reputations for expertise and
scientific leadership in the disciplines
relevant to indoor air research. The
SAB seeks the best judgments of
active research scientists as to what
scientific information is missing in the
various disciplines before independently
ascertaining the research priorities of
the Center.
After the SAB establishes the research
agenda, the Center announces to the
scientific community at large that
research applications in response to
the agenda are being accepted. The
review of proposals and their selection
for funding is accomplished in a
scientifically rigorous and objective
manner. Applications are reviewed
f~t for scientific quality by the appli-
cant's peers selected from the group
listed in Appendix B. The SAB, in
turn, reviews the applications and
peer evaluations, and develops recom-
mendations on the selection of
applications. Studies recommended
by the SAB are subject to final
approval by the Board of Directors.
A staff scientist is assigned to each
funded project to monitor the investi-
gator's progress and to provide assis-
tance to the investigators toward the
successful completion of the project.
When a project is completed, the
investigator submits a draft final report
which is reviewed by the Center for its
scientific quality and soundness of
conclusions. The investigator is
encouraged to publish the work in an
independent, peer reviewed journal for
the benefit of the scientific commtmity
at large.
]3ATCo US DOJ v Philip Morris
Request for
Research
Applications
Introduction
The Center for Indoor Air Research
was established in 1988, as an inde-
pendent, non-profit corporation. Its
primary purpose is to sponsor scientific
and technical research on the sources,
transformation and fate of constituents
affecting indoor air quality; on factors
governing human exposure to, and
retention of those constituents; on the
effects of those constituents on health,
including exposure-response relation-
ships; and on methods of preventing
or abating the concentrations of
indoor air contaminants. The research
program will be supplemented by
periodic conference workshops and
commissioned monographs.
A Science Advisory Board has been
assembled to assist in the formation
and review of the research program.
The Advisory Board consists of
eminent scientists from a range of
disciplines, including environmental
engineering and monitoring, chemistry,
toxicology, microbiology, epidemiolo~,
behavioral sciences and biostatistics.
The following research agenda was
established at a Center for Indoor Air
Research Science Advisory Board
(SAB) Workshop. Research topics of
major interest to the Center are
described in the agenda. Individuals
who intend to apply for funding are
encouraged first to submit a letter of
intent, two-to-three pages in length,
indicating the research objectives,
key elements of the experimental
design and methods, estimated time
required and approximate direct and
indirect cost. The letter should be
addressed to:
Center for Indoor Air Research
1099 Winterson Road, Suite 280
Linthicum, Maryland 21090
| I II
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13ATCo US DOJ v Philip Morns
Research Agenda
In the research agenda that follows,
the Center's priorities and specific
requests for application are presented.
These represent the Center's best
judgment on currently important
research problems, but the agenda is
by no means exhaustive. As stated in
the Introduction, any proposal that is
consistent with the Center's purpose
will be considered. Our objective in
presenting priorities and research
topics is to stimulate researchers to
focus on problems related to indoor
air quality (IAQ).
The research needs that follow are
grouped according to sources investi-
gations, exposure/dose assessment,
heallh effects, perception of IAQ,
and engineering control strategies
for IAQ. This collection of topics
represents one general approach to
indoor air quality research. Numerous
indoor air contaminants warrant
investigation in terms of their fate and
transport in the indoor environment,
the forms and quantities in which they
present themselves to exposed indi-
viduals, the dose actually delivered to
a target (e.g., individual, organ, cell),
strategies to reduce their levels, and
the perception of indoor air quality in
the presence and absence of the contam-
inants. Some contam.inants of interest
are volatile organic compounds
(VOCs), environmental tobacco
smoke (ETS), biological aerosols
(aeroallergens and aeropathogens),
and particulate matter.
Indoor air quality is "'the nature of air
that affects the health and well-being
of occupants" where, according to the
World Health Organization, "health is
a state of complete physical, mental
and social well-being, and not merely
the absence of disease or infirmity".
CIAR is interested in all relevant
chemistry, physics, control strategies
for, health effects caused or aggravated
by, and psychosocial factors influencing
the perception of indoor air quality. Due
to the interdisciplinary nature of
indoor air research, most projects will
encompass more than one of these
areas. CIAR, therefore, encourages
interdepartmental collaborations and
joint projects whenever they serve to
enhance the interpretation and evalua-
tion of results or to strengthen the
validity of conclusions.
SOUrces
Myriad substances in indoor air have
potential to affect health. The sources
are many (e.g., outdoor air, people and
their activities such as cooking, con-
sumer products including pesticides,
heating and cooling systems, building
materials, electronic equipment) and
distributions of sources and chemicals
vary among indoor environments. For
example, certain chemicals might be
added to heating/cooling systems to
exert a biocidal or preservative effect.
The fate and effects of such known-
source agents have not been studied
extensively. Many constituents are
being studied within risk assessment
frameworks as toxicologically-signifi-
cant compounds; however, much work
remains to be done in characterizing
distributions of various agents in
specific envinmmeats related to
sources and assessing their impact on
human health.
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BATCo US DOJ v Philip Morri,,
CIAR is interested in creative proposals
Develop methods to characterize
and quantify source emissions.
Research in this area could include
biologically-based means of source
characterization and product screening,
such as human irritation and odor
assays, as well as development/
improvement of chemical analytical
methods.
Investigate the transport and
environmental fate of indoor air
contaminants, particularly via sinks.
This work will elucidate indoor air
chemistry, and is important in deter-
mining concentrations for short and
long-term exposure estimates.
Develop and validate models to
relate source emissions, fate, and
transport.
The air in virtually all indoor environ-
ments is a complex mixture of low
levels of both reactive and unreactive
species which may interact chemically
or physically in a dynamic equilibrium
between gaseous and particulate phas-
es. The physical and chemical natures
of the species themselves as well as
those of the surrounding environment
could affect the composition of the air
to which an occupant is exposed. For
example, does the presence of moisture
lead to chemical reactions with indoor
air constituents? How and to what
extent do different types of building
materials and surfaces influence the
fate of indoor contaminants?
Elucidate the dynamics of complex
physico- chemical mixtures typical
of indoor environments.
Numerous biological agents in indoor
air may cause human disease. The
most common biological agents found uo~im~.ry
in indoor environments are bacteria,
viruses, fungal spores, algae, arthropod
fragments and droppings,, and animal
dander. Proliferation of microorganisms
is dependent on moisture level and
temperature. These requirements for
growth are often provided by heating
and air conditioning systems, and
humidifiers.
Exposure
Assessment/
The estimates of exposure and inter-
nal dose are critical factors in the
reliability of studies to determine the
health consequences of exposures.
There are at least two critical issues
in exposure-dose relationships: the
effect of aerodynamic respiratory
tract defenses in altering the quantity
and distribution of the exposure to
achieve a tissue dose, and measure-
ment of actual internal dose. The
complex particle-gas composition of
indoor air contaminants has an
important effect on the pulmonary
distribution of the inhaled exposure.
Research proposals are requested on
the following:
Develop sampling methods amenable
to standardization for the characteri-
zation of microorganism concentra-
tions in the indoor environment.
Characterize the size-segregated
distribution of specific antigens in
various indoor environmems.
Attention should be paid to factors
influencing the distribution of the
antigen in settled dust and as air-
borne particles.
Measurements from site-specific
and personal monitoring including
biomarker measurements, are more
reliable than self-reported history of
exposure. In epidemiological studies,
inaccurate reports of exposure history
introduce misclassification bias. In
field studies, the use of inaccurate
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BATCo US DOJ v Philip Morris
estimates of exposure can lead to
variable, unreliable dose-response
data. Appropriate modeling may esti-
mate dose from exposure. Biomarkers
can be useful in studying tissue injury
and to determine dose from the low
levels of exposure common indoors.
Applications are requested for the
following:
Clarify the relationship between
experimental measures of exposure
and self-reporting as a measure of
exposure.
Clarify the relationship between
exposure and dosimetry by conducting
studies to improve the use of bio-
markers together with exposure
monitoring and health effects. This
effort would involve improvements
in pharmacokinetic modeling as well
as methods development for exposure
research.
Particular areas in which there are
limited data are:
- personal monitoring in non-indus-
trial occupations and in high risk
groups;
- time-activity profiles in exposure
studies.
Develop unique, new biomarkers
with the sensitivity and specificity to
be useful in studying injury in both
animals and humans.
Develop assays for detection of
biological markers for exposure,
effect, and susceptibility.
Investigate the use of polyclonal
antibodies for screening in exposure-
dose studies.
Develop and validate models to pre-
dict dose and allow for extrapolation
between animals and humans.
Health
Effects/Responses
Low levels of airborne species may
mediate lung injury by effects related
to cumulative dose or long-term dose
rather than peak dose. This concept is
well-established for lead, where total
dose is as important as dose pattern.
Although there is growing agreement
regarding the techniques used to
measure indoor contaminants, there
remains the problem of whether point
or time-weighted measures are most
meaningful. Given a specific indoor
environment with a characterizable
distribution of airborne substances,
do measure,able health effects relate
to cumulative, chronic, low-level
concentrations, to acute peak concen-
trations, and/or to synergistic effects
between substances?
CIAR is interested in considering
creative proposals to:
Investigate the effects of long-term
steady exposures to non-peak or low
levels of indoor contaminants in
order to determine whether or not
realistic indoor levels of these chem-
icals contribute to overall adverse
health effects.
While many chemical constituents
have been identified in indoor air,
little is known about the chemical
changes that occur therein and the
mechanisms by which they occur. The
chemical fate of single species and
their resulting impacts on health could
vary greatly in different complex
environments. For example, does the
presence of an airborne contaminant
or reaction intermediate alter the
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13ATCo US DOJ v Philip Morris
tissue dose and physiological responses
to other indoor air contaminants?
CIAR will consider creative proposals
tO:
Elucidate the health responses of
interactive, low-level, complex
exposures.
Studies of the relationship between
indoor air contaminants and precisely
def'med cl~cal cl~ases are en~uraged.
Health effect/response questions of
interest to CIAR include:
Do inhaled indoor contaminants
- impair cardiovascular performance
and contribute to the incidence of
angina and myocardial infarction?
- initiate or aggravate bronchial
hyperreactivity in asthmatics and/or
the normal population?
- affect resistance to respiratory infec-
tion?
- affect prenatal and perinatal
development?
- affect cognitive performance?
CIAR requests applications to:
Perform studies to determine the
effects of indoor contaminants on
cardiovascular, pulmonary, immune
system and behavioral function.
Investigate host susceptibility factors
for effects due to inhalation of
indoor contaminants.
CIAR is interested particularly in the
long-term consequences of low level
exposures.
Biological agents may cause allergenic
or pathogenic responses. Indoor
allergens, including those present in
animal dander and arthropod fragments
and droppings, appear to be ubiquitous.
Virtually all homes studied, whether
or not pets have been present, have
exhibited allergens. Such allergens are
risk factors in both the development
of asthma and provocation of acute
asthmatic attacks. Avoidance of the
allergens has been associated with
improvement in the clinical status of
asthma. The extent to which the risk
imposed by specific allergens is
determined by their aerodynamic
characteristics and airborne concen-
trations is uncertain. A variety of
microorganisms including fungi,
bacteria, nematodes and amoebae
have been implicated as producers of
sensitizing antigens responsible for
the development of acute and chronic
forms of immunologically mediated
disease. Elevated humidity and moist
surfaces promote the growth of the
parent organisms. The role of
aempathogens in inducing allergenic
rather than pathogenic responses is an
area of interest to the Center.
Conduct highly-focused studies of
aempathogens (endogenous bacterial
and fungal flora found in specific
envimrar~nts which induce allergenic
rather than pathogenic responses.
Proposed studies in this area should
be promising with respect to yielding
productive, new results.
Relate such health responses to
indicators of host susceptibility.
Develop immunological and
biochemical markers that best char-
acterize susceptibility and response.
Perception of IAQ
A basic objective of environmental
control is to provide for the comfort
and health of occupants. Investigators
have not always been able to identify
specific contaminants responsible for
reported health complaints, the most
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prevalent being eye, nose, and throat
irritation. While considerable progress
has been made in the development of
technology to measure contaminant
concentrations, greater effort is needed
in quantifying human responses to
indoor air environments. Studies to
date have shown that worker health in
office buildings, for example, is
influenced by individual, perceptual,
psychosocial, and psychophysical
factors.
CIAR requests applications for
research to:
Elucidate the relationship among
disorders expressed by occupants in
buildings and the importance of
perception. Determine the baseline
rates of symptom reporting under
various, well-documented circum-
stances. This research would most
likely involve the development of
improved sampling strategies fog
surveying building occupants and
improved serf-reporting measures,
interview techniques, and o~her
approaches to assess occupants'
health problems.
Develop convenient, objective ways,
based on physiological or biochemical
measurements, to assess irritation
and to validate symptoms of irrita-
tion. Improve the sensitivity of
existing indices of eye, throat, and
nasal irritation.
Explore the basis for individual and
group differences in perceptual
sensitivity and annoyance to indoor
contaminants. Relevant factors
could include age, sex, and personal
history of smoking behavior, allergy,
and respiratory infection.
Develop and validate a predictive
human structure-activity model for
irritants. Explore the potential for
extrapolating the existing structure-
activity data for irritants in animals
to humans.
Develop convenient, objective ways
based on objective measurements, to
assess the impomance of pollutant per-
ception on alterations in performance.
Engineering
Control of IAQ
The decrease of indoor contaminants
most probably will lead to reduction
of adverse health effects. The choice
of an engineering control strategy
depends strongly on the psychosocial
and psychophysical influences
described above as well as the
measurable environmental contaminant
concentrations. Therefore, develop-
ment of "healthy building characteris-
tics" involves knowledge of both the
physical environment and occupant
responses.
Applications are requested for:.
Developing engineering strategies to
control either indoor comfort para-
meters or indoor air quality parame-
ters, or both. Strategies that enhance
the welfare of occupants (comfort
parameters) and their health (indoor
air parameters) are preferred to
controls that address just one or the
other.
Developing engineering control
strategies to reduce occupant expo-
sures to indoor air contaminants in
office buildings and in residences.
Develop protocols to assess the
efficiency of each proposed strategy.
Developing criteria and standards
for the design of spaces to be
occupied and for design of control
systems, to minimize or mitigate
indoor air quality problems.
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BATCo US DOJ v Philip Morris
Application
Process
LETTER OF INTENT: CIAR
requests submission of a two to three
page letter of intent, including a
synopsis of the proposed research
with reference to the project's specific
goal(s), the general approach to be
used, identification of all participating
institutions and an estimate of the
total monies that will be requested.
These letters will be used to plan the
proposal review process. The letter of
intent is not binding on CIAR or the
applicant. This letter should be
-eceived no later than thirty (30) days
prior to the deadline for submitting
applications, at the following address:
Center for Indoor Air Research
1099 Winterson Road, Suite 280
Linthicum, Maryland 21090
CIAR will notify the applicant ifa full
application is not warranted.
FORMAT: Applications must be
submitted on the attached
"Application for CIAR Research
Contract". Investigators should
review the Application for CIAR
Research Contract General
Information and Instructions found
on pages 12 to 14. Inquiries regarding
application procedures and review
procedures may be directed to the
Center at the above address or by
calling (410) 684- 3777. If two appli-
cations are interdependent or closely
related, they should be appropriately
cross-referenced in the project plan.
Two copies of the abstract and twelve
(original and eleven) copies of the
application (including abstracO are
needed by CIAR for the review
process.
Each copy of the application, except
the original, should be bound wilh
a label containing the title of the
proposal and the principal investi-
gator's name.
DEADLINES: Applications must be
postmarked by June 1. Proposals not
meeting this deadline will be held for
the next funding cycle.
Management of
Research Contracts
Research Agreements
The Center for Indoor Air Research
awards contracts, renewable annually
for the number of years approved by
the Board of Directors if work is
progressing satisfactorily. The
Research Contract has been designed
to maximize the integrity of the scien-
tific process while providing needed
protections and meeting applicable
regulations. Proposals and any addenda
or modifications will be appended and
made part of the contract.
Progress Reports
Investigators are required to submit
progress reports at five months and
ten months of each contract year,
except for the last year of the project,
when the final report is substituted for
the usual ten-month report. These
reports are reviewed by the project
monitor.
The basic objective of the five month
report is to indicate how much
progress has been made in the devel-
opment of experimental procedures,
which objectives have been completed,
and what problems, if any, have arisen.
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135
BATCo US DOJ v Philip Morris
The ten-month report is actually a
combined progress report and renewal
application for the next year's funding.
CIAR's decision regarding renewal of
the contract is based upon the informa-
tion provided by the investigator in
this repo~ The ten-month report
should provide a detailed account of
experimental results obtained during
the funding period, as well as a discus-
sion of specific objectives for the
coming year and a budget.
Site Visits
CIAR staff (project monitor) usually
conducts site visits to the laboratories
of its funded investigators during the
project period. The purpose of these
visits is to evaluate the status of the
project, and to provide an opportunity
for an exchange of ideas between the
investigator and CIAR scientists.
Final Report
As part of the research project, the
investigator prepares a final report
which describes the study and its
findings. The investigator's draft final
report is reviewed by the project
monitor. Some reports are reviewed
also by peers who represent a broad
range of relevant experience. The
objective of the CIAR review process
is to ensure that the Investigator's
Report is complete, precise, and
understandable. Review comments
may be sent to the investigator who
then has an opportunity to respond to
the comments and, if necessary, to
revise the report. Guidelines for the
preparation of final reports to CIAR
appear in Appendix C.
Publications
It is the policy of the Center to strongly
encourage investigators to publish
results of research conducted with
CIAR funds in the open scientific
literature. The following statement,
acknowledging CIAR support, should
appear in all publications resulting
from work funded by CIAR:
"Research described in this article
was supported (in part) by the
Center for Indoor Air Research."
Original reprints of all journal articles,
copies of abstracts, and review articles
describing CIAR-funded research
should be sent to the Center.
Contract
Administration
Policy
Payments will be made quarterly to
the institution where the research is
being conducted. A payment schedule
other than quarterly must be requested
and approved by the Center prior to
commencement of a contract.
Payments are made upon receipt of an
invoice from the institution.
It is the Center's policy to permit
quarterly billing of 22.5% of the total
contract less equipment. Ten percent
of the total contract amount is with-
held pending receipt and acceptance
of the ten-month/final report by the
Center. Equipment should be invoiced
in the quarter in which it is purchased.
Contracts may not be transferred from
one institution to another due to a
change in affiliation by principal
investigator without express permis-
sion of the Center.
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BATCo US DOJ v Philip Morris
A Contract may be terminated prior to
normal expiration date by the contrac-
tor upon notification to the Center with
a statement of reasons for termination.
Unexpended funds shall be returned
to the Center for Indoor Air Research
either upon expiration or termination
of the project.
Budgets are presumed accurate at the
time of award; however, up to 20% of
the funds may be reapportioned
among all categories, except for travel,
without prior approval. If, for any
unforseen reasons, additional funds or
reapportionments exceeding 20% are
required, such requests will be consid-
ered by the Center upon receipt of a
complete statement of reasons for
such change. PLEASE NOTE: If
funds are reapportioned into category
(g), equipment, and/or category(f),
sub-contracts, subsequent reduction in
category (i), indirect costs, will result
and, thus, reduction in the total project
award.
Application for
CIAR Research
Contract
General Information and Instructions
Submission of
Applications
Complete applications received by the
June 1 st postmark deadline will be
reviewed. Funding of awarded projects
will begin the following January Ist.
Submit the original and eleven addi-
tional copies. If photographs are
included, send one original set.
Submit two additional copies of the
Research Abstract form.
Append as much material as required.
Type, single space, using 8 1/2" x 11"
paper and label each sheet with the
name of the Principal Investigator in
the upper right hand comer. Number
each page consecutively beginning
with page 4. DO NOT insert pages
between form pages FI and F3.
Investigators will receive written
acknowledgement of receipt of the
application.
Research Plan
8. Aims
State the objectives of the research
and the hypotheses you will test.
9. Significance of Proposed Work
Identify gaps in the research area
and discuss pertinent background
material that supports the impor-
tance of the work.
10. Preliminary Studies
Critically evaluate existing knowl-
edge pertinent to the application
with reference to the key litera-
ture. Provide an account of the
principal investigator/program
director's preliminary studies
pertinent to the application and/or
any other information that will
help to establish the experience
and competence of the investigator
to pursue the proposed project.
11. Experimental Design and
Methods
Outline the experimental design
and the procedures to be used to
accomplish the specific aims of
the project. Include the means by
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which the data will be collected,
analyzed, and interpreted. Include
a description of the statistical
methods to be used for analysis
and interpretation of the data.
Describe the proposed statistical
procedures with sufficient detail to
allow evaluation by a biostadstical
reviewer. Describe any new
methodology and its advantage
over existing methodologies.
Discuss the potential difficulties
and limitations of the proposed
procedures and alternative
approaches to achieve the aims.
Provide a tentative sequence or
timetable for the investigation (i.e.,
a columnar or graphical represen-
tation of your schedule for comple-
tion of tasks). Point out any proce-
dures, situations, or materials that
may be hazardous to personnel and
the precautions to be exercised.
Provide a list of literature you cited
in your application~
12. Other Support
List all currently active and pend-
ing support for all key personnel
involved in this proposal. Include
the source of support, percentage
of appointment, dates of project
period, a brief description of the
project and whether it overlaps,
duplicates, replaces, or supplements
this proposed work in any way.
13. Budget
Cost Data: Provide sufficient
detail and analysis to assure the
Center that the proposed costs are
reasonable and that adequate
accounting procedures will be
used. CIAR has no specific limita-
tion on the budgets of research
proposals. Most contracts are
expected to be in the range of
$50,000 to $200,000 per year,
including overhead. Projects
requiring larger budgets must have
exceptional promise for developing
important methods or information
for understanding indoor air quality.
Personnel: List the names and
positions of all applicant organiza-
tion personnel involved in the
project for which salaries are
requested. Note those which are
considered essential to the project.
Estimate the percentage of time or
effort on the project for profes-
sional personnel and non-profes-
sional personnel. List the dollar
amounts separately for each indi-
vidual for salary and fringe bene-
fits. Fringe benefits may be
requested to the extertt that they
are treated consistendy by the
applying organization as a direct
cost to all sponsors.
Consultant Costs: Consultant
service should be explained by
indicating the specific area in
which such service is to be used.
Identify the contemplated consul-
tants. State the number of days of
such services estimated to be
required and the consultant's quomd
rate per day.
Equipment: If special-purpose
equipment is being proposed,
provide a description of the
item(s) and details of the proposed
cost. If fabrication by the applicant
is contemplated, include details of
material, labor, and overhead.
Alterations and Renovations: If
the costs of essential alterations of
facilities, including repairs, paint-
ing, removal or installation of par-
titions, shielding, or air condition-
ing, are requested, itemize them
by category and justify them fully.
BATCo US DOJ v Philip Morris
Supplies and Other Expenses: All
supplies and other expenses should
be itemized in sufficient detail to
allow reviewers to understand the
major categories of expenditures
(i.e., animals, glassware, media
chemicals, as well as publication
costs, page charges, and books,
listed by category and unit cost).
Itemize and justify such items as
patient travel and per diem costs,
rentals, leases, and computer costs.
Unusually expensive items for spe-
cial processes should be separately
identified by quantity and price and
the use or application thoroughly
explained in the project plan. Each
individual expense item must be
categorized as supplies or other
expenses according to the practices
of the accounting office of your
institution.
Travel Expenses: Indicate the esti-
mated number of trips required,
destination, reason for travel, and
cost. Identify and support any
other special transportation costs
attributable to the performance of
this project. CIAR ?ays for foreign
travel only if it is approved in
advance of the trip.
Subcontracts: Itemize and enter a
total for these costs. Describe and
justify all appropriate costs for ser-
vices purchased for, or associated
with, third parties.
Indirect Costs: Indirect costs are
limited to a maximum of 25
percent of budget items, excluding
sub-contracts and equipment on
which no indirect costs are
payable.
Human Subjects: The Center
requires that Institutional Review
Board approval for any procedures
involving human subjects must be
submitted with the application.
Laboratory Animals: The Center
endorses the NIH policies on the
care and use of laboratory animals,
and requires that any proposed
experiment involving the use of
experimental animals be approved
by the Institutional Animal Care and
Use Committee at the investigator's
institution. Documentation of
approval by the local animal care
committee will be required.
Research Abstract: A concise,
descriptive summary of the project
must be submitted with the appli-
cation. A form is provided for this
purpose.
Completeness to Applications:
Provide all information requested.
The signature and typed names of
the institutional officer and princi-
pal investigator must be on the
application.
Notification After Review of
Application: Investigators will be
notified, in writing, of the decision
on their proposal.
Mailing Instructions: Include
eleven copies and an original of
each and every part of the applica-
tion, plus two additional copies of
the Research Abstract form.
NOTE: Each of the eleven copies
must be placed in a binder with a
label containing the title of the
application and the name of the
principal investigator. Mail the
application to:
Center for Indoor Air Research
1099 Winterson Road, Suite 280
Linthicum, Maryland 2 i 090
BATCo US DOJ v Philip Morris
Appendix A
CIAR Membership
CHARTER MEMBERS
Philip Morris U.S.A.
R.J. Reynolds Tobacco Company
Lorillard Corporation
Svenska Tobaks AB
Brown & Williamson Tobacco Corporation
REGULAR MEMBERS
Hoechst Celanese
Mead Paper
Japan Tobacco Inc.
ASSOCIATE MEMBERS
Ecusta, Division of PH Glatfelter
DIMON International
Mundet International Ltd.
Quest Intemalional Flavors, USA
Shorewood Packaging
Somerville Packaging Corp.
Standard Commercial Corp.
United Technologies Carrier Corp.
Universal Corporation
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BLANK SHEET
BATCo US DOJ v Philip Morris
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Appendix B
CIAR Peer Reviewers
Eric W. Adams
United Technologies Research Center
Gerald Akland
U.S. EPA
Janet Arey
University of California, Riverside
San jay Ar0ra
Virginia Polytechnic Institute
Sleven D. Aust
Utah State University
A. J. Baker
The University of Tennessee
Rebecca Bascom
University of Maryland
Bryan R. Becker
University of Missouri-Kansas City
Iris R. Bell
University of Arizona
Collette L Bement
TRC Environmental Corporation
M. A. Benjaminson
Touro College
Janet Benson
Lovelace ITRI
Irwin H. Billick
Gas Research Institute
Malcolm N. Blumenthal
University of Minnesota
William K. Boyes
U.S. EPA
Hoy Bohanon
R. J. Reynolds Tobacco Co.
Terry Brennan
Camroden Associates
Klaus Brunnemann
American Health Foundation
Harriet Burge
Hma,ard School of Public Health
Gary R. Burleson
U.S. EPA
Robert Burrell
West Virginia University Medical Center
Robert Bush
University of Wisconsin Hospital
Silvana Camboni
Ohio State Universi~
Neal Castagnoli, Jr.
Virginia Polytechnic Institute
Jeffrey Cheek
University of California-Davis
Bean T. Chen
ITRI
Qingyan Chen
M.I.T. Department of Architecture
Leslie L. Christianson
University of lllinois-Urhana-Champaign
Theodore Colton
Boston University School of Public ttealth
Emanuela Corsini
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BATCo US DOJ v Philip Morris
Greg Cosma
Colorado State University
Daniel L. Costa
U.S. EPA
Dr. Lucia G. Costa
Universi~." of Washington
Derek L Croome
UniversiO, of Reading - UK
William E. Crouse
Chemical Industry Institute of Toxicology
Jennifer B. Cunningham
TRC Environmental Corporation
Salil K. Das
Meharry Medical College
R. Del Delumyea
Jacksonville University
Amin Dharamsi
OId Dom#don Universi~. , Virginia
Mirjana Djordjevic
American Health Foundation
Douglas W. Dockery
Harvard School of Public Health
Charles Dorgan
Dorgan Associates
Richard L. Dory
University of Pennsylvania Hospital
Russell T. Doweli
Lake Erie College of Osteopathic Medicine
Deborah M. Drechsler-Parks
UniversiD, of California, Santa Barbara
Kevin Driscoll
Proctor & Gamble
Lawrence K. Duffy
Universi~. of Alaska Fairbanks
D. L. Dungworth
University of California-Davis
Bonnie Dunn
U.S. FDA
David A. Eastmond
University of California. Riverside
M. Samy El-Shall
Virginia Commonwealth University
Hugh L. Evans
NYU Medical Center
Henry M. Fales
National Institutes of Health
Jin Bao Fang
National Institute of Standards atld"
Technology
Timothy Ford
Harvard School of Public Health
Mark W. Frampton
UniversiO, of Rochester Medical Center
Bettina M. Francis
University of lllinois-Urbana-Champaign
Donald Gardner
Inhalation Toxicology
John Gatley
Brookhaven National Laboratot3'
Jeffrey Gearhart
ICF Kaiser Engineers Inc.
Robert C. Gesteland
University of Cincinnati
Thomas V. Getchell
University of Kemucky
Nicholas J. Giardino
Brooks AFB
Roger Gie~
Northeastern University
BATCo US DOJ v Philip Morris
Avery. Nelson Gilbert
Synesthetics, Inc.
Stephen L. Gilbert
University of Arizona
Matthew lan Gilmour
University of North Carolina
Leon R. Glicksman
Massachusetts Institute of Technology
Joao F. P. Gomes
University of Lisbon
Henry Gong, Jr.
Rancho Los Amigos Medical Center
Terry Gordon
NYU Medical Center
Ronald E. Gots
National Medical Advisory Service, Inc.
S. Niranjan Goud
University of Kentucky
Charles W. Graham
Texas A&M University
Robert Greene
Thomas Jefferson Medical College
Wayne H. Griest
Oak Ridge National Laboratory
Sergey A. Grinshpt~n
University of Cincinnati
Albert E Gunnison
NYU Medical Center
Fariborz Haghighat
Concordia Uni~,ersit)'
David Hajjar
Cornell University Medical Center
Victor Flasselblad
Center for Hea#h Policy
Research Education
Alan Hedge
Cornell University
David Hemenway
University of Vermont
Doug C. Hittle
Colorado State University
Stuart A. Hoenig
University. of Arizona
Dietrich Hoffmann
American Health Foundation
John R. Hoidal
UniversiO' of Utah Medical Center
G. Thomas Holbrook
Virginia Polytechnic Institute
W. Elliott Homer
Tulane University Medical Center
Ronald Howell
UniversiO' of South Florida
Ling-Ling Hung
U.S. Public Health Service
Hilary I. lnyang
Geoenvironmental Design and
Research Inc.
Roger A. Jenkins
Oak Ridge National Laboratory
Jennifer Johnting
American Health Foundation
Ren Jun
Anhui Anti.Epidemic Station, China
Marry S. Kanarek
University of Wisconsin.Madison
Medical School
John G. Keller
Apex Environmental, Inc.
Randal J. Keller
Universir), of Arkansas for Medical Sciences
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2o
S. James Kilpatrick
Virginia Commonwealth University
Soren Kjaergaard
University of Aarhus
Steven R. Kleeberger
Johns Hopkins University
Michael T. Kleinman
UniversiO' of California.lrvine
Lorry A. Klinger
Rexair, Inc.
Earl Knutson
U.S. Department of Energy
Wendy H. Koch
TRC Environmental Corporation
Loren Koller
Oregon State Universi~.,
Petros Koutrakis
Harvard School of Public Health
Michael R. Kuhlman
Battelle
John Lacey
Rothamsted, UK
Souheil Laham
Ottawa, Canada
Susan M. Larson
University of Hlinois-Urbana-Champaign
Jerold A. Last
Universio, of California-Davis
Christopher Si-Lung Lau
U.S. EPA
Michael D. Lebowitz
University of Arizona College of Medicine
Bruce Lehnert
Los Alamos National LaboratmT
Samuel B. Lehmr
Tulane UniversiO' Medical Center
David Leith
UniversiO, of North Carolina
Estelle Levetin
University of Tulsa
Robert Lewis
U.S. EPA
Roger Lewis
St. Louis University
Waiter Lewis
Washington University
Paul F. Linden
UniversiO, of Cambridge - UK
Bill Linn
Rancho Los Amigos Medical Center
Franklin Loew
Tufts University
Tyler S. Lorig
Washington & Lee University
Sudarshan K. Loyalka
UniversiO' of Missouri-Columbia
Joseph Lstiburek
Building Science Corp.
Robert Luebke
U.S. EPA
B. Madhusudhan
UniversiO' of Mysore, India
Jeannette McGIone
Dalhousie UniversiO'
James J. McGrath
U. S. EPA
Milton Meckler
Meckler Engineers Group
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John H. Mennear
Campbell University
Daniel Menzel
University of California-lrvine
Robert Mercer
Duke University Medical Center
John W. Mitchell
University of Wisconsin-Madison
Somenath Mitra
New Jersey Institute of Technology
Maria T. Morandi
University of Texas
Philip R. Morey
Clayton Environmental Consultants. inc.
Brooke Mossman
University o[ Vermont
Thomas E. Mull
Technology Resource Consulting
Engineers, lnc.
Stanley A. Mumma
The Pennsylvania State University
Donald E. Myers
University of Arizona
Niren L. Nagda
ENERGEN Consulting, Inc.
William Nazaroff
University of California-Berkeley
Abroad Nevissi
University of Washington
P. J. Nieholls
Welsh School of Pharmacy
Gunnar Nielson
Danish National Institute of
Occupational Health
Marc Nishimoto
NOAA
Michael W. O'Callaghan
Tufts University
Carol O'Neil
Tulane University Medical Center
Mary Kay O'Rourke
University of Arizona College of Medicine
Michael Ogden
R. J. Reynolds Tobacco Co.
James Otten
Camber Corp.
David Otto
U.S. EPA
Haluk Ozkaynak
Har~,ard School of Public Health
Kenneth C. Palmer
Wayne State University
S. S. Parmar
University of North Dakota
Darrell W. Pepper
University of Nevada-Los Vegas
Sere H. Phan
University of Michigan Medical School
Sarah Pixley
University of Cincinnati
Charles G. Ploppcr
University of California.Davis
William T. Porter
University of Tulsa
Neil R. Pumford
University of Arkansas for Medical
Sciences
J. Michael Ramsey
Oak Ridge National Laboratory
Rose Ramsey
Oak Ridge National Laboratory
]3ATCo US DOJ v Philip Morris
John Reif
Colorado State Universi~.
Parker C. Reist
University of North Carolina-Chapel Hill
Gary L. Ritter
TRC Environmental Corporation
John Roboz
Mount Sinai School of Medicine
Brian A. Rock
The University of Kansas
John M. Rogers
U.S. EPA
Charles Rohde
Johns Hopkins Universi~."
Mark J. Rood
Unh'ersiO' of Illinois at Urbana-Champaign
Herbert Rosenkranz
Universit)' of Pittsburgh
Gary Rosenthal
Somatogen Inc.
James RotlOn
Florida International University
John C. Rutledge
Universi~ of California-Davis
P. Barry Ryan
The Rollins School of Public Health
of Emory University
Lisa Ryan
U.S. EPA
Ragnar Rylander
University of Gothenberg, Sweden
Namir Saman
Cons~dtant
Behzad S. Samimi
San Diego State University
Harry J. Sauer, Jr.
Universio, of Missouri-Rolla
Marcia Sawnor
Erdman AnthotLv Consulting Engineers
Dennis Schuetzle
Ford Motor Company
Mary Jane Selgrade
U.S. EPA
James M. Seltzer
Indoor Hygienic Technologies Corp.
Mihir Sen
UniversiO, of No~re Dame
Richard B. Setlow
Brookhaven National Laboratoo'
Vinod Kumar Sharma
b~dira Gandhi Institute
Richard Shaughnessy
University of Tulsa
S. A. Sherif
University of Florida
C. Y. Shaw
IRC, Canada
Joseph H. Shinn
Lawrence Livermore National Laboratoo"
Charles L. Sidman
UniversiO' of Cincinnati
Wayne Silver
Wake Forest University
Jean D. Sipe
Boston Universi~. School of Medicine
Douglas A. Smith
University of Toledo
Raymond A. Smilh
Universi~. ' of Nebraska Medical Center
BATCo US DOJ v Philip Morris
Jerome J. Solomon
NYU Medical Center
E. William Spannhake
Johns Hopkins University
Donald H. Stedman
University of Denver
Linda D. Stetzenbach
University of Nevada-Las Vegas
Thomas H. Stock
University of Texas School of Public Health
Jan Stolwijk
Yale University School of Medicine
Gary D. Stoner
Ohio State University
David C. Straus
Texas Tech University Health Sciences
Center
Bruce Stuart
ManTech Environmental Technologies
Kerry Sublette
University of Tulsa
David L. Swift
Johns Hopkins University
You-Zhi Tang
Bovar.Concord Environmental
Robert W. Temple
GulfCreat International, Inc.
Nell W. Tindale
Texas A&M Un&ersity
Greg Traynor
Lawrence Berkeley Laboratory.
Simon Turner
Healthy Buildings International
Walter S. Tyler
University of California-Davis
James Ultman
Penn State University
Peter Valberg
Gradient Corp.
Gary Van Berkel
Oak Ridge National Laboratory
Karen M. Vetrano
TRC Environmental Corporation
James H. Vincent
Unh,ersity of Minnesota
Jamboor K. Vishwanatha
University of Nebraska Medical Center
Lance Wallace
U.S. EPA
John Weisburger
American Health Foundation
Kenneth J. Welch
S. C. Johnson & Son, Inc.
Janell D. Wenger
Johnson Controls, Inc.
Art Wheeler
Wheeler Engineering
Jeffrey Whitsert
Children's Hospital Research Foundation
Marshall Williams
The Ohio State University
Marsha Wills-Karp
The Johns Hopkins University
Tomasz Wihowski
Southern Illinois University
John Wispe
Children's Hospital Medical Center
Hanspeter Witschi
University of California-Davis
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James Yager
Johns Hopkins University Medical Center
Chin S. Yang
P & K Microbiology Services
Hsu-Chi Yeh
Lovelace ITRI
Vali Yousefi
National Centre for Occupational Health
South Afi'ica
Paolo Zannetti
Failure Analysis Associates, Inc.
Judith T. Zelikoff
NYU Medical Center
Jianshun Zhang, Ph.D.
National Research Council Canada
Yuanhui Zhang
Prairie Swine Centre Inc.
BATCo US DOJ v Philip Morris
Appendix C
Guidelines for Final
Report to ClAR
The provision of the final report to
CIAR is a major contractual responsi-
bility of the CIAR-sponsored principal
investigator. It is a comprehensive
account to the funding organization of
all work accomplished with monies
supplied by the organization toward
the objectives and specific aims set out
in the approved version of the investi-
gators' proposal.
The f'mal report should contain:
- A description of the original objec-
tives and intentions, the rationale for
the objectives, and reasons for
research redirections.
- A complete data report including
tables and graphs, and descriptions
of methodologies used to obtain
the data.
- Interpretive results. That is, how
was the data evaluated and what do
they mean?
- Principal Investigator's summary
and conclusions.
-If applicable, brief suggestions for
specific future research aims directly
related to the stated objectives.
- A comprehensive list of all
abstracts, oral presentations, and
joumal manuscripts (submitted, in
press,and published) which resulted
from CIAR-supported work. Please
include reprints, preferably origi-
nals, for any published works
acknowledging CIAR support not
already sent to CIAR.
The final report is a technical docu-
ment subject to peer review for
scientific clarity and soundness and,
therefore, should communicate the
project objectives, design, and
conclusions well. The f'mal report
should not contain new proposals
whether or not related to the work
reported therein.
Adherence to these guidelines will
facilitate a timely f'mal report
approval, disbursement of withheld
dollars, and contract termination.
BATCo US DOJ v Philip Morris
The Center for Indoor Air Research
wishes to acknowledge the assistance
of the following:
The Health Effects Institute (HEI) for
sharing their Request for Application
and mailing list. Portions of this RFA
were based on the application proce-
dures and administrative policies
developed by HEI. Our use of their
material recognizes the considerable
efforts they have made to produce an
effective application and
administrative policy that meets the
needs of both the contracting agency
and the researchers. Use of this
material does not imply, nor is there
any association between our two
organizations;
The U.S. Department of Health and
Human Services as portions of the
application forms and instructions
were modeled on the Grant
Application Form PHS 398.
BATCo US DOJ v Philip Morris
Research Abstract
Title of Project:
Investigator(s):
Institution:
ABSTRACT: In the space below, please provide a descriptive summary of your proposed research
project.
Signature, Principal Investigator Date
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BATCo US DOJ v Philip Morris
Application for
Research Contract
CENTER FOR INDOOR AIR RESEARCH
1099 Winterson Road, Suite 280, Linthicum, MD 21090
(410) 684-3777 FAX (410) 684-3729
1. Principal Investigator. Name, Title, Telephone ~, and mailing addre~.
fa) (b)
(c)
Name T, de
Telephone #/Fax *
(d) (e)
[~anmant Institution
(0
Mailing Address
Star efZip
2. Project Title.
3. Key Words. Please provide three (3) key words which will be used as reference headings.
4. Institution. Name and address of institution responsible and accountable for disgx~ition of funds
awarded on the basis of this application.
(a). (b)
Institution Street Address
(c).
(d)
Ciqt
State~ip
5. Location. List location where research will be conducted if other than instituion identified in
.4 above.
6. Inclusive Dates and Total Costs of this specific project related to each 12 month period if more
than one year is required to com-
plete project. Summarize from budget page, item 14(j). It must be understood that awards for 2nd
and 3rd periods are dependent on
Center approval of continuation application.
Inclusive Date Total Cost
(a) 1st 12 month period ~__ $
(b) 2nd 12 month period (if required) r.hnl_ $
(c) 3rd 12 month period (ifm=luired). .thru $
7. Institutional Officer. Name, title and telephone number of individual authorized to s:gn for the
institution identified in *4 above.
It is understood that the officer, in applying for a contract, has read and found acceptable the
Center's Management of Research
Contracts and Contract Administration Policy.
Name
Telephone
8. Aims*
(a) Hypoth~
(h} Objectiv~
9. Significance of Proposed Work*.
(a) ~
(h)
(c) Importance of Project
10. Preliminary Studies*.
(a) Fo~ibili~, of Propoxd I~--arch
(b) Qualifications oflnv~agator
11. Experimental Plan*.
(a) D~i~
(h) Merhod~
(c) Anal~i~ of data
(d) interpretation ofr~ul~
(e) Timetable for the invesriOrion
(f) Literature cited
12. Available Facilities and Resources*.
13. Other Support*
Title
(a) (e)
Signature of Institutional Officer Date
*Al~end as much material as ~luired. TYPE, single space, use 8-1/2" x 11" white paper and label each
sheet with name of the principal investigator in the upper right
hand comer and page number at the bottom. Consecut|vely number each addendum beginning with page 4.
Do not insert pages between form pages FI and F3.
Include eleven copie~ and an original. If sending photog~phs, include I original set. Note: Each of
the eleven copies nma be bound per mailing instructions.
O
O
BATCo US DOJ v Philip Morris
14. Budget. Detail specific needs for the first 12-month period. Estimate cattegor3, sub-totals for
2nd and 3rd periods, if
required. Append justifications.
(a) Salaries, List personnel by name and ntle.
Indicate individuals % time to be slxen~ on this project.
Technical:
Fringe Benefits payable at institution's rate of %
Categoq, (a) SubTotal
Ih) Comultants (per diem, travel & expeme~):
Ic) Supplies & Expenses:
Consumables (by categor’)
Animals and related costs
Othe’ Expenses (itemize)
Category (b) SubTotal
Catego~/(c) SubTotal
(d) Travel Expenses:
Category (d) SubTotal
(e) Alterations and Renovations
Categor’ (e) SubTotal
Category (0 SubTotal
Subcontracts
(g) Equipment
Catego~ (g) SubTotal
(h) TOTAL DIRECT COSTS
$ $ $
period 2nd period 3rd period
(i) lndiaxt corn not to exceed 25% d the sum of (a) thin (e):
(j) TOTAL PROJECTS COSTS
15. Biographical Sketch of all professional personnel listed in 14(a). Append. Please include the
following: Name, title,
education, scientific field, major research interest and/or professional experience and
publications. (Limit list of
publications to the 20 most important and/or relevant,)
16. a) Are Human Subjects to be used in this research? Yes
If yes, attach Institutional Review Board approval for procedures involving human subjects.
No
b) Are Laboratory Animals to be used in this research? Yes No
If yes, attach Institutional Animal Care and Use Committee approval for procedures involving
animals.
17. Signature of Principal Investigator:
Signature of Principal Investigator
Date
BATCo US DOJ v Philip Morris
Board of Directors
Charles R. Green, Ph.D., Chairman
$co~t Appleton, Ph.D.
Richard A. Carchman, Ph.D.
J. Daniel Heck, Ph.D.
Lutz Mueller, Ph.D.
Helmut M. Reif, Ph.D,
Tilford Rieh!
Alex W. Spears, Ph.D.
Inger Wahlberg, Ph.D.
Executive Director
Max Eisenberg, Ph.D.
Staff
Marsha S. Buss, C.P.A., Program Manager Administration
Lynn Kosak-Channing, Ph.D., Staff Scientist
Alice V. Zeiger, Ph.D., M.B.A., Staff Scientist
Paula G. Raimondo, M.L.S., Manager of Library Sen,ices
V. Christine MarquardL Administrative Assistant
BATCo US DOJ v Philip Morris
.I
CENTER FOR INDOOR AIR RESEARCH
1099 Winterson Road, Suite 280
Linthicum, Maryland 21090
(410) 684-3777
FAX (410) 684-3729
E-mail: ciarinc@aol.com
BATCo US DOJ v Philip Morris
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