BATCo
1996-1997 Research Agenda - Request for Applications
Fields
- Named Organization
- World Health Organization
- University of Minnesota
- University of Lisbon
- NYU Medical Center
- Concordia University
- University of Vermont
- Colorado State University
- University of Pittsburgh
- University of Gothenburg
- San Diego State University
- University of Missouri-Rolla
- University of Tulsa
- Wake Forest University
- University of Toledo
- Tufts University
- US Public Health Service
- National Institute of Standards and Technology
- Virginia Commonwealth University
- US FDA
- University of Washington
- University of Illinois
- Philip Morris USA
- Brown & Williamson Tobacco Corporation
- Japan Tobacco Incorporated
- US EPA
- Meharry Medical College
- Oak Ridge National Laboratory
- US Department of Energy
- TRC Environmental Corporation
- Washington University
- Campbell University
- Danish National Institute of Occupational Health
- Penn State University
- Science Advisory Board
- Svenska Tobaks AB
- Ecusta
- Texas A&M University
- Meckler Engineers Group
- University of Arkansas for Medical Sciences
- University of Aarhus
- Proctor & Gamble
- Ford Motor Company
- Virginia Polytechnic Institute
- NIEHS
- Standard Commercial Corporation
- Shorewood Packaging
- Pennsylvania State University, The
- University of Mysore
- University of Tennessee, The
- DIMON International
- Cornell University Medical Centre
- New York University Medical Centre
- Ottawa
- Mead Paper
- Mundet International Limited
- Quest International Flavors USA
- Somerville Packaging Corporation
- United Technologies Carrier Corporation
- Gas Research Institute
- Touro College
- United Technologies Research Centre
- ITRI
- University of Alaska Fairbanks
- Dorgan Associates
- NYU Medical Centre
- ICF Kaiser Engineers Incorporated
- National Medical Advisory Service Incorporated
- University of North Arizona
- Synesthetics Incorporated
- Apex Environmental Incorporated
- Tulane University Medical Centre
- Rexair Incorporated
- Battelle
- St Louis University
- Building Science Corporation
- IRC Canada
- University of Denvar
- Johnston Controls Incorporated
- National Centre for Occupational Health South Africa
- Prairie Swine Centre Incorporated
- Health Effects Institute, The
- University of Kentucky
- University of California
- University of Texas
- University of Reading
- Southern Illinois University
- RJ Reynolds Tobacco GmbH
- University of Maryland
- Johns Hopkins School of Hygiene and Public Health
- Illinois Institute of Technology
- Brookhaven National Laboratory
- Virginia Polytechnic Institute and State University
- Universal Corporation
- Lorillard Corporation
- Utah State University
- American Health Foundation
- Harvard School of Public Health
- University of Wisconsin Hospital
- Ohio State University
- University of Maryland School of Medicine
- Boston University School of Public Health
- Jacksonville University
- National Institute of Health Guidelines Committee
- Northeastern University
- University of North Carolina
- Named Person
- Lebowitz, Michael D
- Woods, James E
- Levetin, Estelle
- Eisenberg, Max
- Kessler, Irving
- Matanoski, Genevieve M
- Utell, Mark J
- Wolf, Alfred P
- Adams, Eric W
- Arora, Sanjay
- Aust, Steven D
- Bascom, Rebecca
- Bell, Iris R
- Benjaminson, MA
- Billick, Irwin H
- Blumenthal, Malcolm N
- Brennan, Terry
- Burleson, Gary R
- Burrell, Robert
- Cheek, Jeffrey
- Chen, Qingyan
- Croome, Derek J
- Crouse, William E
- Cain, William S
- Das, Salil K
- Delumyea, R Del
- Dorgan, Charles
- Dowell, Russell T
- Driscoll, Kevin
- Dunn, Bonnie
- Evans, Hugh L
- Fales, Henry M
- Frampton, Mark W
- Larson, Susan M
- Francis, Bettina M
- Gardner, Donald
- Last, Jerold A
- Gearhart, Jeffrey
- Getchell, Thomas V
- Giardino, Nicholas J
- Giese, Roger
- Gilbert, Stephen L
- Hedge, Alan
- Lehrer, Samuel B
- Glicksman, Leon R
- Ford, Timothy
- Jenkins, Roger A
- Gong, Henry
- Meckler, Milton
- Gordon, Terry
- Greene, Robert
- Haghighat, Fariborz
- Hajjar, David
- Hasselblad, Victor
- Hemenway, David
- Reif, John
- Roboz, John
- Rogers, John M
- Sen, Mihir
- Sharma, Vinod Kumar
- Silver, Wayne
- Smith, Douglas A
- Stoner, Gary D
- Stuart, Bruce
- Temple, Robert W
- Turner, Simon
- Tyler, Walter S
- Ultman, James
- Wallace, Lance
- Wispe, John
- Yager, James
- Yang, Chin S
- Zhang, Yuanhui
- Guerin, Michael R
- Lewis, Roger
- Lippman, Morton
- Witschi, Hanspeter
- Kilpatrick, James
- Akland, Gerald
- Burge, Harriet
- Bush, Robert
- Djordjevic, Mirjana
- Dockery, Douglas W
- Doty, Richard L
- Hoidal, John R
- Johnting, Jennifer
- Kanarek, Marty S
- Kleeberger, Steven R
- Kleinman, Michael T
- Knutson, Earl
- Kuhlman, Michael R
- Lewis, Robert
- Loyalka, Sudarshan K
- McGrath, James J
- Mennear, John H
- Nielson, Gunnar
- Ogden, Michael
- Otto, David
- Rohde, Charles
- Spannhake, E William
- Valberg, Peter
- Moschandreas, Demetrios
- Arey, Janet
- Hoffman, Dietrich
- Bohanon, Hoy
- Nagda, Niren L
- Brunnemann, Klaus
- Kilpatrick, S James
- Camboni, Silvana
- Klinger, Lorry A
- Menzel, Daniel
- Palmer, Kenneth C
- Potter, William T
- Ramsey, J Michael
- Stedman, Donald H
- Benson, Janet
- Baker, AJ
- Castagnoli, Neal
- Costa, Daniel L
- Rood, Mark J
- Lacey, John
- Leith, David
- Bement, Collette L
- Boyse, William K
- Christianson, Leslie L
- Cosma, Greg
- Costa, Lucio G
- Cunningham, Jennifer B
- Dharamsi, Amin
- Duffy, Lawrence K
- Eastmond, David A
- Fang, Jin Bao
- Gatley, John
- Gilbert, Avery Nelson
- Gilmour, Matthew Ian
- Gornes, Joao FP
- Goud, S Niranjan
- Graham, Charles W
- Grinsh, Sergey A
- Hittle, Doug C
- Holbrook, G Thomas
- Horner, W Elliott
- Hung, Ling-Ling
- Inyang, Hilary I
- Keller, John G
- Kjaergaard, Soren
- Koch, Wendy H
- Lehnert, Bruce
- Linn, Bill
- Lorig, Tyler S
- Madhusudhan, B
- Koller, Loren
- Koutrakis, Petros
- Nishimoto, Marc
- O'Callaghan, Michael W
- O'Neil, Carol
- Otten, James
- Ritter, Gary L
- Saman, Namir
- Samini, Behzad S
- Ryan, Lisa
- Smith, Raymond A
- Sauer, Hary J
- Sawnor, Marcia
- Solornon, Jerome J
- Swift, David L
- van Berkel, Gary
- Yousefi, Vali
- Zannetti, Paolo
- Zelikoff, Judiath T
- Notes
Author name is not available in the document Missing originals: 800105409-800106141. Handwritten.
- UCSF Code
- hle51a99
- Type
- agenda
- table
- Region
- United Kingdom
- China
- Sweden
- Canada
- South Africa
- Date Loaded
- 01 Dec 2004
- Box
- 0161
- Folder
- bcmn0000
Document Images
-t
• CENTER FOR INDOOR AIR RESEARCH
1996-t997
RESEARCH
AGENDA
REQUEST FOR
APPLICATIONS
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BATCo US DOJ v Philip Morris
Mission Statement
The mission of the Center for Indoor Air Research is to sponsor high quality
research on indoor air issues and to facilitate communication of research findings
to the broad .scientific community.
Science Advisory Board Members
William S. Cain, Ph.D.
Professor, Department of Surgery (Otolaryngology)
University of Califomia, San Diego
Michael R. Guerin, Ph.D.
Head, Organic Chemistry Section
Analytical Chemistry Division
Oak Ridge National Laboratory
Irving Kessler, M.D., Dr.P.H.
Professor, Department of Epidemiology and Preventive Medicine
University of Maryland School of Medicine
Morton Lippmann, Ph.D.
Vice-Chairman, Department of Environmental Medicine
New York University Medical Center
Genevieve M. MatanOski, M.D., Dr.P.H.
Professor, Department of Epidemiology
Johns Hopkins School of Hygiene and Public Health
Demelrios Moschandreas, Ph.D.
Professor, Pritzker Department of Environmental Engineering
Illinois Institute of Technology
Mark J. Utell, M.D.
Professor, Medicine and Toxicology
University of Rochester School of Medicine
Alfred P. Wolf, Ph.D.
Director, Cyclotron - PET Program
Brookhaven National Laboratory
James E. Woods, Jr., Ph.D., P.E.
Professor, College of Architecture and Urban Studies
Virginia Polytechnic Institute and State University
t3ATCo US DOJ v Philip Morris
J~uary, 1996
Dear Investigator:
I am plsased to provide you th~ Center for Indoor Air Research's "Request for
Applications" booklet. This package includes information about the Center,
the research and review process, procedures for application, the contract man-
agement process and the application forms. Also included is our Research
Agenda which describes CIAR's research interests.
Applications must be postmarked by June 1st. Funding of awarded projects
begins the following January I st.
If you have additional questions concerning application procedures, please
contact the Center at (410) 684-3777,
Thank you for your interest.
Sincerely,
"°" J
Bg~Co US DO
Table of Contents
Research and Review Process
.................................................................................. 3
Research Agenda
....................................................................................................
... 5
Application Process
................................................................................................. 10
Management of Research Contracts
....................................................................... 10
Contract Administration Policy
.............................................................................. 11
Application - General Information and Instructions ............................................. 12
Application Forms
.......................................................................................... FI - F3
Appendix A: CIAR Membership
........................................................................... 15
Appendix B: CIAR Peer Reviewers
....................................................................... 17
Appendix C: CIAR Final Report Guidelines .........................................................
25
Acknowledgements
................................................................................................. 26
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Center for Indoor
Air Research
The Center for Indoor Air Research
(CIAR) is a non-profit corporation
fonmed in March, 1988 to sponsor
high quality research on indoor air
issues and to facilitate communication
of research findings to the broad scien-
tific community.
The Center has three classes of mem-
bership: charter members, regular
members and associate members (See
Appendix A). The charter members
are those corporations that established
the Center and are currently providing
the majority of the funding. Regular
and associate members are those per-
sons or corporations that are interested
in indoor air quality research but were
not involved in the establishment of
the Center. The regular members are
represented on the Board of Directors
while the associate members are not.
The Center is actively seeking addi-
tional members in both the regular
and associate categories. Additional
information on membership can be
obtained by contacting the Center.
The Center has established a Science
Advisory Board (SAB) which develops
the research agenda for approval by
the Board of Directors. The SAB
recommends proposals for funding
after they have been peer reviewed by
the Center's pool of peer reviewers.
This structure ensures that only high
quality research which will contribute
to the knowledge bank on indoor air is
recommended for funding.
Research and
Review Process
The research agenda of the Center for
Indoor Air Research is formulated by
the Science Advisory Board (SAB), a
multi-disciplinary group of individuals
with reputations for expertise and
scientific leadership in the disciplines
relevant to indoor air research. The
SAB seeks the best judgments of
active research scientists as to what
scientific information is missing in the
various disciplines before independently
ascertaining the research priorities of
the Center.
After the SAB establishes the research
agenda, the Center announces to the
scientific community at large that
research applications in response to
the agenda are being accepted. The
review of proposals and their selection
for funding is accomplished in a
scientifically rigorous and objective
manner. Applications are reviewed
f~t for scientific quality by the appli-
cant's peers selected from the group
listed in Appendix B. The SAB, in
turn, reviews the applications and
peer evaluations, and develops recom-
mendations on the selection of
applications. Studies recommended
by the SAB are subject to final
approval by the Board of Directors.
A staff scientist is assigned to each
funded project to monitor the investi-
gator's progress and to provide assis-
tance to the investigators toward the
successful completion of the project.
When a project is completed, the
investigator submits a draft final report
which is reviewed by the Center for its
scientific quality and soundness of
conclusions. The investigator is
encouraged to publish the work in an
independent, peer reviewed journal for
the benefit of the scientific commtmity
at large.
]3ATCo US DOJ v Philip Morris
Request for
Research
Applications
Introduction
The Center for Indoor Air Research
was established in 1988, as an inde-
pendent, non-profit corporation. Its
primary purpose is to sponsor scientific
and technical research on the sources,
transformation and fate of constituents
affecting indoor air quality; on factors
governing human exposure to, and
retention of those constituents; on the
effects of those constituents on health,
including exposure-response relation-
ships; and on methods of preventing
or abating the concentrations of
indoor air contaminants. The research
program will be supplemented by
periodic conference workshops and
commissioned monographs.
A Science Advisory Board has been
assembled to assist in the formation
and review of the research program.
The Advisory Board consists of
eminent scientists from a range of
disciplines, including environmental
engineering and monitoring, chemistry,
toxicology, microbiology, epidemiolo~,
behavioral sciences and biostatistics.
The following research agenda was
established at a Center for Indoor Air
Research Science Advisory Board
(SAB) Workshop. Research topics of
major interest to the Center are
described in the agenda. Individuals
who intend to apply for funding are
encouraged first to submit a letter of
intent, two-to-three pages in length,
indicating the research objectives,
key elements of the experimental
design and methods, estimated time
required and approximate direct and
indirect cost. The letter should be
addressed to:
Center for Indoor Air Research
1099 Winterson Road, Suite 280
Linthicum, Maryland 21090
| I II
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Research Agenda
In the research agenda that follows,
the Center's priorities and specific
requests for application are presented.
These represent the Center's best
judgment on currently important
research problems, but the agenda is
by no means exhaustive. As stated in
the Introduction, any proposal that is
consistent with the Center's purpose
will be considered. Our objective in
presenting priorities and research
topics is to stimulate researchers to
focus on problems related to indoor
air quality (IAQ).
The research needs that follow are
grouped according to sources investi-
gations, exposure/dose assessment,
heallh effects, perception of IAQ,
and engineering control strategies
for IAQ. This collection of topics
represents one general approach to
indoor air quality research. Numerous
indoor air contaminants warrant
investigation in terms of their fate and
transport in the indoor environment,
the forms and quantities in which they
present themselves to exposed indi-
viduals, the dose actually delivered to
a target (e.g., individual, organ, cell),
strategies to reduce their levels, and
the perception of indoor air quality in
the presence and absence of the contam-
inants. Some contam.inants of interest
are volatile organic compounds
(VOCs), environmental tobacco
smoke (ETS), biological aerosols
(aeroallergens and aeropathogens),
and particulate matter.
Indoor air quality is "'the nature of air
that affects the health and well-being
of occupants" where, according to the
World Health Organization, "health is
a state of complete physical, mental
and social well-being, and not merely
the absence of disease or infirmity".
CIAR is interested in all relevant
chemistry, physics, control strategies
for, health effects caused or aggravated
by, and psychosocial factors influencing
the perception of indoor air quality. Due
to the interdisciplinary nature of
indoor air research, most projects will
encompass more than one of these
areas. CIAR, therefore, encourages
interdepartmental collaborations and
joint projects whenever they serve to
enhance the interpretation and evalua-
tion of results or to strengthen the
validity of conclusions.
SOUrces
Myriad substances in indoor air have
potential to affect health. The sources
are many (e.g., outdoor air, people and
their activities such as cooking, con-
sumer products including pesticides,
heating and cooling systems, building
materials, electronic equipment) and
distributions of sources and chemicals
vary among indoor environments. For
example, certain chemicals might be
added to heating/cooling systems to
exert a biocidal or preservative effect.
The fate and effects of such known-
source agents have not been studied
extensively. Many constituents are
being studied within risk assessment
frameworks as toxicologically-signifi-
cant compounds; however, much work
remains to be done in characterizing
distributions of various agents in
specific envinmmeats related to
sources and assessing their impact on
human health.
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BATCo US DOJ v Philip Morri,,
CIAR is interested in creative proposals
• Develop methods to characterize
and quantify source emissions.
Research in this area could include
biologically-based means of source
characterization and product screening,
such as human irritation and odor
assays, as well as development/
improvement of chemical analytical
methods.
• Investigate the transport and
environmental fate of indoor air
contaminants, particularly via sinks.
This work will elucidate indoor air
chemistry, and is important in deter-
mining concentrations for short and
long-term exposure estimates.
• Develop and validate models to
relate source emissions, fate, and
transport.
The air in virtually all indoor environ-
ments is a complex mixture of low
levels of both reactive and unreactive
species which may interact chemically
or physically in a dynamic equilibrium
between gaseous and particulate phas-
es. The physical and chemical natures
of the species themselves as well as
those of the surrounding environment
could affect the composition of the air
to which an occupant is exposed. For
example, does the presence of moisture
lead to chemical reactions with indoor
air constituents? How and to what
extent do different types of building
materials and surfaces influence the
fate of indoor contaminants?
• Elucidate the dynamics of complex
physico- chemical mixtures typical
of indoor environments.
Numerous biological agents in indoor
air may cause human disease. The
most common biological agents found uo~im~.ry
in indoor environments are bacteria,
viruses, fungal spores, algae, arthropod
fragments and droppings,, and animal
dander. Proliferation of microorganisms
is dependent on moisture level and
temperature. These requirements for
growth are often provided by heating
and air conditioning systems, and
humidifiers.
Exposure
Assessment/
The estimates of exposure and inter-
nal dose are critical factors in the
reliability of studies to determine the
health consequences of exposures.
There are at least two critical issues
in exposure-dose relationships: the
effect of aerodynamic respiratory
tract defenses in altering the quantity
and distribution of the exposure to
achieve a tissue dose, and measure-
ment of actual internal dose. The
complex particle-gas composition of
indoor air contaminants has an
important effect on the pulmonary
distribution of the inhaled exposure.
Research proposals are requested on
the following:
• Develop sampling methods amenable
to standardization for the characteri-
zation of microorganism concentra-
tions in the indoor environment.
• Characterize the size-segregated
distribution of specific antigens in
various indoor environmems.
Attention should be paid to factors
influencing the distribution of the
antigen in settled dust and as air-
borne particles.
Measurements from site-specific
and personal monitoring including
biomarker measurements, are more
reliable than self-reported history of
exposure. In epidemiological studies,
inaccurate reports of exposure history
introduce misclassification bias. In
field studies, the use of inaccurate
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BATCo US DOJ v Philip Morris
estimates of exposure can lead to
variable, unreliable dose-response
data. Appropriate modeling may esti-
mate dose from exposure. Biomarkers
can be useful in studying tissue injury
and to determine dose from the low
levels of exposure common indoors.
Applications are requested for the
following:
• Clarify the relationship between
experimental measures of exposure
and self-reporting as a measure of
exposure.
• Clarify the relationship between
exposure and dosimetry by conducting
studies to improve the use of bio-
markers together with exposure
monitoring and health effects. This
effort would involve improvements
in pharmacokinetic modeling as well
as methods development for exposure
research.
Particular areas in which there are
limited data are:
- personal monitoring in non-indus-
trial occupations and in high risk
groups;
- time-activity profiles in exposure
studies.
• Develop unique, new biomarkers
with the sensitivity and specificity to
be useful in studying injury in both
animals and humans.
• Develop assays for detection of
biological markers for exposure,
effect, and susceptibility.
• Investigate the use of polyclonal
antibodies for screening in exposure-
dose studies.
• Develop and validate models to pre-
dict dose and allow for extrapolation
between animals and humans.
Health
Effects/Responses
Low levels of airborne species may
mediate lung injury by effects related
to cumulative dose or long-term dose
rather than peak dose. This concept is
well-established for lead, where total
dose is as important as dose pattern.
Although there is growing agreement
regarding the techniques used to
measure indoor contaminants, there
remains the problem of whether point
or time-weighted measures are most
meaningful. Given a specific indoor
environment with a characterizable
distribution of airborne substances,
do measure,able health effects relate
to cumulative, chronic, low-level
concentrations, to acute peak concen-
trations, and/or to synergistic effects
between substances?
CIAR is interested in considering
creative proposals to:
• Investigate the effects of long-term
steady exposures to non-peak or low
levels of indoor contaminants in
order to determine whether or not
realistic indoor levels of these chem-
icals contribute to overall adverse
health effects.
While many chemical constituents
have been identified in indoor air,
little is known about the chemical
changes that occur therein and the
mechanisms by which they occur. The
chemical fate of single species and
their resulting impacts on health could
vary greatly in different complex
environments. For example, does the
presence of an airborne contaminant
or reaction intermediate alter the
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13ATCo US DOJ v Philip Morris
tissue dose and physiological responses
to other indoor air contaminants?
CIAR will consider creative proposals
tO:
• Elucidate the health responses of
interactive, low-level, complex
exposures.
Studies of the relationship between
indoor air contaminants and precisely
def'med cl~cal cl~ases are en~uraged.
Health effect/response questions of
interest to CIAR include:
• Do inhaled indoor contaminants
- impair cardiovascular performance
and contribute to the incidence of
angina and myocardial infarction?
- initiate or aggravate bronchial
hyperreactivity in asthmatics and/or
the normal population?
- affect resistance to respiratory infec-
tion?
- affect prenatal and perinatal
development?
- affect cognitive performance?
CIAR requests applications to:
• Perform studies to determine the
effects of indoor contaminants on
cardiovascular, pulmonary, immune
system and behavioral function.
• Investigate host susceptibility factors
for effects due to inhalation of
indoor contaminants.
CIAR is interested particularly in the
long-term consequences of low level
exposures.
Biological agents may cause allergenic
or pathogenic responses. Indoor
allergens, including those present in
animal dander and arthropod fragments
and droppings, appear to be ubiquitous.
Virtually all homes studied, whether
or not pets have been present, have
exhibited allergens. Such allergens are
risk factors in both the development
of asthma and provocation of acute
asthmatic attacks. Avoidance of the
allergens has been associated with
improvement in the clinical status of
asthma. The extent to which the risk
imposed by specific allergens is
determined by their aerodynamic
characteristics and airborne concen-
trations is uncertain. A variety of
microorganisms including fungi,
bacteria, nematodes and amoebae
have been implicated as producers of
sensitizing antigens responsible for
the development of acute and chronic
forms of immunologically mediated
disease. Elevated humidity and moist
surfaces promote the growth of the
parent organisms. The role of
aempathogens in inducing allergenic
rather than pathogenic responses is an
area of interest to the Center.
• Conduct highly-focused studies of
aempathogens (endogenous bacterial
and fungal flora found in specific
envimrar~nts which induce allergenic
rather than pathogenic responses.
Proposed studies in this area should
be promising with respect to yielding
productive, new results.
• Relate such health responses to
indicators of host susceptibility.
• Develop immunological and
biochemical markers that best char-
acterize susceptibility and response.
Perception of IAQ
A basic objective of environmental
control is to provide for the comfort
and health of occupants. Investigators
have not always been able to identify
specific contaminants responsible for
reported health complaints, the most
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