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~Tobacco Company June 19, 1996 MICHAEL W. OGDEN, PH.D. R. J. REYNOLDS TOBACCO COMPANY P. O. Box 1236 W~NSTON-SALEM, NC 2"7102-1236 TELE~'~IONE: (910) ?41-5787 FACSIMILE: (910) 741-5019 MINUTES FROM CORESTA'S ETS SUB-GROUP MEETING Milan, Italy May 28-29, 1996 Attendees: Gunnar Anderson, Jan Arnm-p, Takuya Asai, Nicola Attwood, Thierry Birkel, Hoy Bob.anon, Barrie Frost, Jtlrgen Hollweg, Masao Matsukura, Michael Ogden, Tatsuya Ono, Jean-Jacques Piad6, Yves Saint-Jalm, Gerhard Soberer, Stephen Sears, Oskar Stuhl, Ruy de Villas-Boas, and Nigel Warren SUB-GROUP BUSINESS Work within the Sub-Group continues on the task to conduct a world-wide survey of existing ventilation conditions in workplace and hospitality locations. The proposedsurvey is expected to show that current ventilation practices do not meet existing standards. Such an outcome would support the premise that more Draconian ventilation practices under consideration by some standard-setting bodies will not solve IAQ problems. What is needed is compliance with existing regulations. The first step in our work, to develop a standard protocol that can be used world-wide to evaluate ventilation, is complete. This task was performed among a group chaired by Hoy Bohanon that included Nigel Warren, Masao Matsukm'a, and Helmut Reif. The survey has been completed in Japan and plans are nearing completion for conducting the survey in France, the UK, and the US in the upcoming months (see more discussion under Technical Program). The ETS Sub-Group continues to plan a collaborative study of the ETS methods for gravimetric RSP, UVPM, FPM, solanesol, nicotine, and 3-ethertylpyridine. The outcome of the collaborative study (i.e., the method performance parameters r and R) is necessary for inclusion into the technical standards for adoption as CORESTA recommended methods and for submission to ISO. Mike Ogden leads a group consisting of Barrie Frost and J-J Piad6 to organize this study. Dr. Ogden reported a delay in conducting the study; however, work is to resume over the summer months. Fourteen labs have tentatively agreed to participate. The concern of the Scientific Commission was relayed to the Sub-Group over the submission by ANSI of the ETS methods for RSP, UVPM, and FPM to ISO as a proposed new work item. In the .opinion of the Scientific Commission, submission of these methods to ISO should be under the jurisdiction of CORESTA since the Sub-Group had already accepted them as work items for collaborative study and development as CORESTA recommended AQ11234 0 0 0 r,.O

ETS Sub-Group Minutes June 19, 1996 page 2 methods with the intent to submit them to ISO. The action by ANSI was an attempt to accelerate the process within ISO by having the proposed methods accepted as new work items in parallel with the Sub-Group's activities aimed at developing the full technical standards. For comparison, it has taken nearly 7 years for ISO to adopt the CORESTA Recommended Method No. 14 for nicotine in ETS. Although the Sub-Group convenor was not involved in the decision by ANSI to submit these methods to ISO as proposed new work items, he did agree to the request from US TAGfFC 126 to serve as technical contact since the methods originated in his laboratory. Dr. Ogden apologized for any misunderstanding or confusion this may have caused. Following discussion, it was decided that the ETS Sub-Group would not hold a formal meeting during the CORESTA Congress in Yokohama (3-8 November, 1996). Progress in the collaborative study and the ventilation study projects will be discussed informally among Sub-Group members in attendance at the Congress. TECHNICAL PROGRAM A summary of topics and speakers comprising the technical program is the following: Report On Ventilation Committee's Progress (Restaurant ETS Survey) - Hoy Bohanon (RJR), Masao Matsulcura (yrI), Yves Saint-Jalm (SEITA); Effect Of Lighting And Storage Conditions On The Stability Of UVPM, FPM, And Solanesol - Mike Ogden (R/R); Determination Of ETS- RSP:Partieulate Marker Ratios For International Cigarettes - M. Ogden; 4-(Methylnitmsamino)- 1-(3-Pyridyl)-l-Butanone (NNK) In ETS - Gerhard Sehcrcr (VdC); Biomarkers For ETS Exposure - G. Scherer; RSP Measurements In/ndoor Air (A Tentative Proposal) - Jehn-Jaeques. Piadd (PM); Report On ASHRAE Activities - H. Bohanon; Report On ASTM Activities - M. Ogden; Report On SCOTH Activities - Stephen Sears 0LIR). Each of the speakers is commended for his contribution to the program. Hoy Bohanon began the discussion on the restaurant survey progress. He is nearing completion of the planning for a 5-restaurant survey in Winston-Salem and Greensboro in conjunction with Lodllard scientists. Testing is expected to begin in June. Masao Matsukqa-a reported that selection of 5 restaurants in the Tokyo area was completed in mid-April and he presented initial data from one restaurant. Prelim~ary indications are that there was not much air exchange, high CO2, and high ambient RSP. Yves Saint-Jalm presented a finalized plan for testing one restaurant in the Paris area. He will use a contract lab to conduct the survey and will select the restaurant in June and hopes to begin testing in September or October. In discussion, Barrie Frost indicated that several UK companies had also agreed to work through an independent contract laboratory. Tentative plans are to test lO restaurants in the Harrogate area, although final agreemeat on funding etc. has aot been reached. AQI 1234

ETS Sub-Group Minutes June 19, 1996 page 3 Mike Ogden reported on stability of UVPM, FPM, and solanesol. Previous reports of instability in the presence of sunlight were confirmed, along with potential degradation in the presence of intense fluorescent light. However, when using filter holders in the manner they have been used in the recent large air quality studies in the US (by R JR and Oak Ridge National Lab) and in Europe (by Coming Hazleton), i.e., with clear filter holders oriented with the inlet side down and with white opaque security bands around the holders, there is no problem with stability of UVPM, FPM, or solanesol. As an added preeatrtion, however, opaque black filter holders (part no. 225-309 from SKC, Inc.) are recommended for future use in place of dear polystyrene holders. M. Ogden also reported on a recently-completed study to determine UVPM- and FPM-to- surrogate standard faeters and the solanesol composition of ETS-RSP for international cigarette brands. These factors and ratios are necessary to apportion total RSP into the fraction attributable to ETS. Notwithstanding slight differences in UVPM and FPM for France (higher than average UVPM and FPM per microgram ETS-RSP) and solanesol for the Czech Republic (lower than average solanesol per microgram ETS-RSP), ratios and factors were relatively consistent. Other countries studied included: Germany, Hong Kong, Italy, Malaysia, Portugal, Spain, Sweden, Switzerland, and the United States. At the specific invitation of the eonvenor, Gerhard Scherer made presentations on NNK in ETS and an overview ofbiomarkers for ETS exposure. Regarding NNK in ETS, Dr. Seherer reported that the very small mount of NNK in ETS is in the particulate phase and that there is no off- gassing from room surfaces like there sometimes is for nicotine. Although it was made clear by the convertor that no new work items were being proposed for the Sub-Group, Dr. Seherer's presentation on biomarkers served as an excellent overview of the trend in exposure monitoring research efforts in many laboratories both within and outside the indust~. J-J Piad6 presented a tentative proposal co-authored with Ted Sanders. This proposal recognizes the non-ETS-specific nature of many methods used to estimate ETS-RSP in indoor air quality investigations, such as gravimelxie, UVPM, FPM, piezobalance, and light-scattering methods. No specific activities were recommended for SubGroup investigation at this time. However, the possibility of work related to better understanding the degree of potential error due to light- scattering calibration techniques and potential interferences in the UVPM and FPM methodologies was discussed. The authors were asked to give these latter points some additional consideration and, if interested, approach the Sub-Group at a later date with a more specific proposal for new work items. Mike Ogden reported that the R JR ETS methods for RSP, UVPM, and FPM have reached final approval as official methods within ASTM (American Society for Testing and Materials). Additionally, the ASTM method for ETS nicotine has been updated and expanded to include 3- ethenylpyridine and it also has reached final approval. These methods are ASTM method numbers D5955 and D5075, respectively. AQ11234 0 0 C) (.0

ETS Sub-Group Minutes June 19, 1996 page 4 Hoy Bohanon informed the Sub-Group that a new standard which incorporates much of Ole Fanger's sensory/perception work was out of ASHRAE (American Society for Heating Refrigerating and Air-Conditioning Engineers) committee in April. It is anticipated that this new standard may be out of the Society by July. It is believed that this standard can be used to determine the "acceptability". of IAQ, and thus ban substances (like ETS) that some find objectionable, based on no real science. Stephen Sears updated us on activities within the SCOTH (Scientific Committee on Tobacco and Health) committee in the UK. The SCOTH report will be limited to reported associations between ETS and lung cancer and Nicholas Wald has been commissioned to write a substantial part of it. Wald's report to the committee is expected in mid-July. Respectfully submitted, Michael W. Ogden, Convertor AQ 11234 0 0 0

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