Tobacco Documents Online

RESEARCH PLANNING BRITISH-AMERICAN TOBACCO COMPANY Rogont'8 P•ek Ro•d. Southlimplon, 809 1PE TOielJltelte I;ogshanDloe 734•1 ~r. W.a. Foz~yce, 3:ttL•h Tobscse Co, (Aust:aliJ) I:d., G.F.O. bx 2609, Sydney 2001, NeSeWer 15tb Januaz'y, 1969 Coo: ~Lam, "~e have received you= lo~t•r o.c bth Jan~zy, :e~es*.tn; our v1~;s on the q~e•tLon• of ZabeZlf~ ¢iwe~e pecks wtt~: (•) • csut/ona:Y wa:nlng; T~ end/or nico~inm delivozie•. ~=vLou•ly, no-one in ~ J~st.ry would fay•v: such • s~ep, ~ut ".ha a:;,:aents ag:ins: the m~e o: the other would sees to be dtffe:L-.t. l"ne:e~oz~, Z ~uld like 1~ sopazal~ thorn in :y reply. { a ) Csuttonaz~ .ia~i n=. ;my reasoned ~unte:-az~FwJnt hare :ust dapand on t~e exac~ • m:dL%. ^ vague s*.atumn~- such e• "Ct~te smYJng my be ha~.~ul to boelth" is • lot easier to live w$~h t.~an ~ m:: specific, such is "Excessive cLgalette mkt~;, l• asrmctatad utth an lnr~eesed risk of decth f:m: lung cance:." If a clause such J• ~ l~tte: we~o used~ I can.t ~hLn~ of am/ a~guaent in z'e:~ul:stJ.on ot, he~ ~ 'th81; the risk depend~ also on ~Jl• nature of the p~odkac~, ~ ~ormLity of ~ sz~ke:r, his o=~gin of birth and ~e degree of u:bsnisa/~t~m to wh!¢h he has been exposed. 3~ none of these otis= fool;ors excludes the deg~• of exposu:e t;o smoke. Pe:haps it shows ~he extent of =V "conditt~a~" by an~-~nok~ng p~op~gsnd~, but Z con.-.ot think of • ~ood scLent~ftc a.-gument against • c~iona~ waznL, q; in general tez~8, except the~ it p~Jsup~ses that ~he blolo~Lr.al activity of ~o'oar.co s:noke ~::m 811 types of cig82qrtte p:oduct8 is siall~r, l ze~u.-n 1:o t~;ls point In my m~we:r to tb). ~hon t~e ca~lonsz~ la~el was ~od In l~m U.S.A., rams p0~plo bel~evod ~a~ ~ht• served warning on ~he cm.~ner of 1~o ~sk" and that ~t ~uld an end I~ •11 l~w suils ~s~ns~ tobtcco ¢m~=a~es. T~s s~11 a~unt of commission say p~sstbly evaporate ~lth • b111 ~e~:e t~ L~ssa~us~tt• Sta~e 14~$sla~u:• w~tch specL~ca11y states 1~ the BAT Co LTD - MINNESOTA TOBACCO LITIGATION

RESEARCH PLANNING -2- w~-ntng ~s not a clefence agaLnst cla~s /or legal l~ablll~ by a censure:. V~ho~her a constantly re-tee:seed :sW~ton of this type has any effec~ on ~okozs is, I suggest, outstd: the azguinto Personally, I doubt the value o," it. (b) T~ ,icottne ftoures Per obvious ~esons, it does not see= feasible to p:J~t ~ f~.~s on the pack, ~less ~ aze ~.~gh en=u~h to ac~modate the ex+.:o=i .~--'gh of the Zange o~ values oncow~a:e~- owLng ~a vaz~atLoas In blend and/o: cop g:ades. No doubt you can cLte f:o: you: own axpe=~once the sort." of var~.m~ions enoun~ezed on • day-~o-day, weok-t~qmek, o: mnt~to-mnt.~ exaatnal;lon of a ~and. The ~=o samples, examlnad~ ~be s~z~z you a:e of the sway in ~he ~igu:es. ~ven so, an ove~age 4ellvozy t~l~e canno~. zopzesen~1:ive of t.he ptz~-tculsz sub-sample o.= cigarettes in 1~ pa:~et o~ 20 pu:chaaed by a consum~:. The alternetLve - ~he publication of leag~e tables - Is :o:e difficult to a:guo a~a2ns~, ~rovicte~ ths~ ?.he sampIe exa~tned £s suff~ciontZy large ar~ that 1~11S sample Is d~awn ~zom ~ milker in a sl~at!stlcally ac~ep~Ze msrme: as fu11¥ :epzesen~r~lve of l~e cl~a:ettu availa'~le to the censum/:~ public. ~von so~ ~he F.T.C. ~thod as p:ectised Ln the U.S.A. ~s rat ye~ accepted by the U.$. CampanLes an¢~ ~o~ntly with • ha P.T.C. 1;hey a~e ~:~.~ng to establish an A.~.A.C. approved eel:hOd. This is one way of dra~,gt~ their ~eet, perhaps, but it Illustrates soa~ o~ t,~ potn~s of difference. The F.T.C. ~ethod l:mr~s on~y 100 cLgarettes =~ each brand, w~oaa ~ U.S. tndua~/ Insists thst 2~0 ¢lgi~etl;es a~e the utn~:~.'~. TF~.-e Le also the a=g~..en: .oyez bm.~-long~., whe:e F.T.C. over-:uled thai: ChalcDon (Psui Rand D~xon) and the ~ndust.~/, and f~.xed on 2~ :~ w)~:ever p~ssible, These aztlumen:s wez~ all Zql~:41Ja:m@d a suh~ssion to ~J~ ~.T.C. by the U.S. lawyers in ea:ly 1968, and I enclose m copy tn case you have r~ seen i~. Howeve:: once these statLrtlca-: and tecYmLcal polnl:~ are ove=como: we have to ~ace ~.e pz'oblem o~ what the LrJL~'oa mean. Even if one conr.edes that the I~U figuzes az~ some messuzm of ~he exposu~, of ~.hm smoke:, and 'that, one can absolve ~he gls and v~pou:r p~ase i~om any t~a~'~.. ful e!fect: we ~z~ p esuppos4.~g that all types of concli~4m~m a=m of e~ua! bJ~olo~ic~l mctl~.ty l~wa=ds ~ human. ?;e aL=~Ldy knor~ ~=~: expe:~n~s in wk:tch o~nde~sstes a=. p~$n~ed on mouse skin, ~t Lt is poaslble to p=oducm coodensstea w2th d~ ffa:~.q~ sp~cSEtc ~ akin ictLy/~y, e.g. flue-cu~ed vs. U.S. bim~d c~g~e=~es, Col~2d=lan cl;~at~e ~ondens4~es (~un~z and ~k - of whom you are awe=e, ) ~A~ p~esence ~ndmmmt of C~S ~!C~01" l"ecOs~Ltu'~d tobacco sheets, '~'xe ~lHa 0:~ ack~t:~vel i~Gh as sodtu= n£1~ate. ;!e believe 1;hat othaz Facto:s my also a!t;e~ ~ specific mouse s~n tumortgentct~/, e.g. m~ts par ~r~h a~ pu:f vol~ ar~ pe:haps BAT Co LTD - MINNESOTA TOBACCO LITIGATION m O

RESEARCH PLANNING -3- pu.m.: f:equency. So a :Jas~-e o,= T]~ yte1~ in t3~ absence o~ any qualt- ft~tton ze~~ the nZstLve haza~-d to h~ms of d~ff~ condensa~es coul~. be alsludlng. Th~s ~e one aspect where t~ Aus~altan sa:ks'~ d~:fezs ~ that in ~ U.L, In tha~ you have blended cLg~es avai!ab~e t= the consum:. T~ere a:e lndLca~ions (no an:e ".~ that) that th: pseous ar~ vapouz phase of smoke nay play some ps:-~ in the aetLology of ~onchLt~-sp ~seas and csz~lovaecul~ disease. As you Y.qawj pc=pie a:e 1ookt~ f=: ni~:osaa~nes (which are likely ~ occ~: .in ld~ v~pou= phase) ~n~ are al:eady suspicious of ~he :ales wht©h oxides a~ n~tz~)gen and c~:~m ~onoxtde mLgt~ play. Xf theso suapict~ns w~:e ~o b~ ~ta~d in s==z way or ano~hez, It would be~om~ oov%ous tha~ T~ is an t~cc~ate ~.~n one has disposed of a12 t;~ess fac~=zs, we s=e 2e~ wl~ ~ p~blem that the risk w111 no~ be equzl fo: all smoJm:'s, bu: wtl! defend on ~.be ex~en~ and depth of inha181~on oy the £ndLvtdual. I ed~all be sending you sho~'~Zy 8 ~repu~l%ca~on copy of a psp~ by Dav~es and ~aym of Haurz~te, c~n 'the campa:ison of mouse skin tumzigenict~y o~ c~ga.-e~ta --~d ciga:r l~becco condenutes which, natu:slly, :us~ be kept conf~den'.i-; until pu~lic~!on in ~he 3:t~iSh Jou:r~l of Can¢~, in ab.~xt 6 montl-.s. -his c=ncZudes ~ha~ c!ga-~ condansa~e is :o:e ~m0o~i;xmic ~ mouse skin ~.-d ~t the Im-~ez ~isk i$1oc~al~d wi~h c!~a~s ~s p~obab!y exp~ined the fact that cigaz mokezs do ~ot ~Ze ~o ~he same extent as c~.gJ:et~e saake:s. ~s is an a:ea whez'a ~i ~Lgu:es on ~het: mm would be =m~less as a n~asu:e of :is~. Up to this poin~, X have endeavo~:ed to I~1k o~ TF:," ~r~res only. Zt would be p=e~e~able ,~ tho a:~mmnt could excZude n~catlne. The evidence Lmpl~cat~ nicotine in lun; c4ncs= Is negltgtb1~ ~r~ As only m Zl~tlo ~z=ne: with ~espect ~o ca:dJov~scula: disease. A Good case £ p:esent could be md~ fo: ~1~-~ nlcotine a clean h£11 of health. Although we :ay believe ~3~at nicotl.-~ can bo abs:lved f=:: any dlzec~ causal connexion with a dtse:ce sue.4 as Lung c~nce: cz athe:oscle.'osAs, v.~ =us~ :~ea~ez =.~ tl is a ~oxic co=po~ and consec~er~ly ~.e s,~auld steps to ensue ~ha~ ~-, individual sh=~Id be able ~c p:o~ec~ hi~se~ ~:=~ ave: dosage wl'.e:e ~his Ls ~z~i~lc=~ec~ C~e way mt;}~t be to class~ty cigsz~ttos fo: exa:ple into ~ree ~:oups b~sed on ~e ni~o~!na deAivez£es, s=ch ms H1;h NA=o~Ine..~=.-:sl N~cottne and ~:~ ,~L~tLae. ~:'.~J~Ln each g:oup one c:uld, i.* one vrl~-.ed, "~s:uula~e b:ands acco:dlng to TR~.deZ~vuy. Thls wou%~ pe:~ps help ~0 d~sseci~e T~t deZive:~es t=o= yields o! nlc~Ane snc~ t~.us a~.d ~=:~" a :el~AveLy i~c~ous c~ with a tum~Agenlc brush. You =ay ze=m=~e: ~ha; this is t.h~ pollcy l~ne which the U.E. ~anu- fsctm:s ~:ried t~ adopt which led t~ the concept of Law 1:at, natal BAT Co LTD - MINNESOTA TOBACCO LITIGATION

RESEARCH PLANNING -.1- nicotine ciga:ette. This app.-each is on!y -u!ly v'J.able if the ¢onsu=a: can c~sciously select the Law ~, no~L r.lcot£ne cl~ts in p:efe=ence to noel ta:, no~:al nicotine ct~es and ~ t~zzn thLs calls re: publication of ~gu:es of TI~ (and nlcol~ne?) Zf you azB 21kely to be faced wt'~ the pubLtaat~on af ~ figu:es~ t1: is woztb tzy£ng "co dlssoc:Lsts ~mn fzom nicotines and t= bage z~edy n~ catego=ies of b=ands co~spond~ t~s ,(a) (b) ~;~, no.-mal nlcottne dellve.-y! Low TF'.'~ Low nicotine 6elAve:y. )kxveve:, you ~st ~e p:ep~d fa: ~ ~edL~l ~st~s~ls~t ~: pu~ f~a:d the view ~hat :educLng the T~'J yield of clgaze~es is unlikm!y to be a haz:fuL step only pzovtded t.~atz (i) SuDkars do no~ I:=ke :o~e of the modified ciga:ette; (li) The/ do not '.n~Le the sake re:e; (lli) The C~ga:~S~'.es ore no*. ~=d!~Sod in :n'[- o~e: ,~ay t~bat ~l~ht increase ~he hsza:ds of maokSn: ~ ~e.g. nil.ares LeaP.try; ~o inc:eased ~live:y of oxides of nit:o;en. These aze .oues~ions whLch ~e ve:y dt~ficuL~ to ~nr.-e=, since "..~y depend uaoa the beh~vtou:sZ p~ta.-n of smke=ss who ~:e wama=e that t~ey o=t being "expe:Laen~ed" on. :no sol,ion ~ould be to :~t a se:tes o: • expensive co.-.mma: tests ~sing ~o~if~ed clgl~e~tes. Zt is ~:~h :eca!l~ng at t~s point that no C~ve~n~s as far as i ~= ~a:e, has evez sta~ officially ~a~ a cism:&.~e y-~aldlng l=we: T]~ is in ~ way "I~E.~O~". ~ ~nt is &].Ways &lor~ ~o IL~eS "r..ha~ the consult :us£ be free "~o make the choice h/ self. Tl~:e is, cLeamLy, a P.R~ ax~a=ent in ad~ttion 1~ t~ scienl"~fic one, and l a: in contact with M:. ~:gx:ve, who will be sending M~. ~lddup amy ammuniq~ton available fz'~: tha'r f~nt. Z hope the fozeg=tng is o~ so:~ help in drm~J.~g up you= courr~a=- p:oposals. .iith kind ~:~a:~s, CG P.D. Tlndley, Esq. G.A. P~esl~m~ Esq. D:. S.J. Gx.en G.C. ~:~:~ve, ~. D.G. F~ZOK •mc. F 514 BAT Co LTD - MINNESOTA TOBACCO LITIGATION m r,,o r',o