Tobacco Documents Online

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Check List Co~e___!r: Nne~. !_ I I~. ~.~ t ...... ';'~s ~ £I is ~~ to £~£~te and d~ the ~ii o£ G.R. & D.C. Re~s should bo ea~emmed st t~o ~tnm o1" the ~'Lt~ I:Tp~ and &ceo~]paz~ the t~pesc~ipt (an~ maJeCe::~ aJ~ ~¢-o~tA~) 8% ~11 l~l~lll~ rb~l. Xt n~It be 1~% %0 CIB~Zm/ fil~z~4~ w~th "\ ITot~e: Ci_-~na~¢£mn ~b~tld be de~ez~Aned by t3~e Zssue~. The tT~escz'lpt nnurt not be lr~'esoa~od for l:=~=t~i~ ~utAl the Zss~er has AnitAalled ~he ~ terms a~ "P~ Muter". After ~=im~ing, one bound copy ~'c be =et'u..--~s~d. to %he Zseme¢" for Eir~ a~=~v&l eu~d the Issue= will ensure ~hat one cop~ is seen b~ %he Mamager. ~m %24 O~ ~ :£o LTD - MINNF_SOTA TOBACCO LITIGATION

This worm was produced on the Ktgnatic Card ~yps~riter. Zt iS ~eratlvt that all corrections, &lttrJtioDs, etc., are made clearly. K.G. pencilled commas, £uLl-scops cou1.d be easily missed. • cross in the marg/~, in line with the correction vould draw our -ttent£on to the insertion. Would you plisse be kind enough to wr£ce lerse insertions on a separate sheet of paper, and no__~t cut out portions of typed work. This is because the HaKnet£c Cards differ from Paper Tapes. ~m=mb ~ ~ Co LTD - MINNESOTA TOBACCO LITIGATION

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• STLTXSTZCAL ~ALTIIZ$ OF TEE ~DMLS DI NO. RD.1690 RESTItZCTED ! 14.9.1979 J~TROK: E.B. W£XEos ISSUED BT: 8. K. Evelyn PROG. REF. 11.05.01 DLSTIIBIEI~I: Dr. 8.J. Groin Copy llo. 1 Dr. D.G. Yeltcm " " 2, 3 LibrazT " " 4, 5 COPY NO. (.,< "--4 ~ ~, Co LTD - MINNESOTA TOBACCO LITIGATION

INDEX HAS INDICATED GAP IN BATES RANGE HERE

EBWIltAl a,6D- 2 Croup ~esearch & Developaenc Centre, Brittsh-A~erieanTobaeco Co. Led., ~N. l~th September 1979. , nX:T~ m~TSZS 07 ~ ~c~ oF ~m~omuUaa ~s ~ J~S x~sx~sm Bll (e-port Is. BD.1690 ~striotod) SOH~&T The bLolosLc~l observatimas of this experiment hive aLrgdy been x epoz~ed (see re£. 1). TnLs report describes a statistical analys£s of some of the d&t4 add leads to the £ollov~ag conclusions:- The conde~s&te £rom the PCL ¢iEazettos was suL:Sinally less active thxn that grom the eostrol tobacco eiSarette. ~. The activity of the ST~ condens&te in less chart half that o£ the coutrol ciga:etts. On a Per ciKarette basis, the SR~ material is at leae~ 3~ times less active than ~Am cmxt:ol tobacco or tbsl~L; there is little difference becveen the control and the FCL. It ks elmer chat the ~ process yields a sheet materlal v~th s~paif£cantly :educed bioloSical actlv£~y. Only a ms~inal reduction is achieved by the PCL proclssbut emrl~er results h~voshovn that c~er©~nl PCL e~sred £mu=ablyvith a staz~Lard blend. On the basis of the biolosicsl results tAse use o£ ALT £s :ecogmm~Aed whenever this ks r~ssibls. ~ k! Co LTD - MINNESOTA TOBACCO LITIGATION

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-2- OKJKCTI~ES The objective of this ezper~t was to compaze the L~mor£Ke~£c ~:tivitles ot the couAmumtes f=om ciSazettes made from F~ and SILT vlth I~8t Of the coode~sste from cl$sretces conta/z~.~ the blend from vh£ch cl~e L~o recouJtituted ~oheccos ve:e made. &n u~pai~ted acetone co~Crol ~oup of au~JutIs was &leo ~uscluded 4n this experiment to monitor the eponr~tnaouJ tiL~n ~smou~ rate of the aJL~JmlS beJJ~8 used. DESZGH OF EX~[IZI(EHT $ The control cLBazetces were ma4e from flue-cu=ad tobacco cut ac 60 cues par /J~h for the lIL/J~ and 160--180 cuts pax" inch for the stem; ¢~0 1~ Co stem retie In the ciKaratces was 60/40. The reconsc£cuced esg Ln the test e~aretcam m cut at 60 c.p.i. 131 ciKareCces were '~) mm in lensch, 25 mm in circumference, wrapped £u Bollor~ O15 VecKe paper. No filter tips yore used. Details of amimal husbandry and condomsate production are given in ~IL). Three dose levels mere used £or each of the three condensaces, and Ohm STceap of aaJJ~lS u painted with acetone/racer solvent concainin~ I~, condensate, so that a total of 10 8:oups o£ a~imals were used. The l wmbezs o£ animals in the var4ou4 Fmxps were:- C~:~ol Bll/I PC~ Bll/2 BII/3 28.3 84 253 252 Dose Level ~0.0 84 253 252 56.6 84 253 253 '~ \ Co LTD - MINNESOTA TOBACCO LITIGATION kj-I ka,,a m P",,O

INDEX HAS INDICATED GAP IN BATES RANGE HERE