Tobacco Documents Online

~CFrdL/~366D--6 G:oup Itse~ch & Dmvelopmmr. Cmncre, BricLsb-~rican Tobacoo Co. Ltd., SOOTRkt4VJ~a. 21st acrobat, L977 (U'poct Ha. RD.1530 Unclass£fLod) puff duplicator devaloptd £n Sour~ap~ has beemused as a tese~cch 8mo~LugmachLae to t~rasclSate :he msLn mad LnCecact£ou e~faccs o£ puff volume, puff shape and JLnvsrvals bevuee: puffs on r~e del£ve:£os Of T]~, a:~cot~e and ¢8~bo~monmr~6e, r.ha r&tLos of l~e dalLyerLt8 of ~ecompouemts and tl~f~l~ati~ne~flclen~] for ~ and ~icot~ne. It m found, thstpuff vol~, t=terval beCweenpu~fs and puff shape each had a s£JnJ~£c4mt e~fect on deliveries and dal£vez~r ratios ~t ~ro we:e also cons£de:able 4nta:acr~Lon effects present. T~Lsmom~s ~t it ks impractical I~ use • kaowLedsa of tota~ volume of su~ka taken by : smoker mad s#:mnd.mzdmmr..J:d[~e smoked del£vecias Co p:ed£cC Ohm deLiva=£es at the ratios o£ vbadalLve:£as of c£Sa:mc~l smok~ co~poum~cs. J~ the p~ue~t ~Lm8 dup~Lur~L~n of ac~al tnman smoi~J~ patte~xs $~vas ~emost ~J~bLe d~t£vetTestLmate8, BAT Co LTD - MINNESOTA TOBACCO LITIGATION m

INDEX HAS INDICATED GAP IN BATES RANGE HERE

w2w Whu the human msokLnS patte~ recorded Ln a previous axper/mant (I) were duplicated it was shots that the TPN to nicotine :at£os achLtved by the panel Rra 8enataLly lo~ than when the sums e~Ka~ettes were smoked by a standard 8moklnK maeh£na to che standard 8moklnK conditions. This difference has been attributed to the ray in u~Lch the human subjects smoked the cigarettes. From the results of the ~ e~perimant (L) it was observed that £mnaLs smokers t~sd to have L~ TPH to nicotine ratios than male s~bjects and that senerally there are dLfferences between the' way in which male and female sub~ecu smoke c£sarettes. The female smokers tended to take more puffs of smaLLer volume per puff 8t mort frequent £nte~wsls than male smokers. The peak flow rates of the in~£v/~ual puffs taken b7 female smokers tended to be lower and the r£sLus edge of the puff profile sharper than those taken by male smokers. EvL4ence has beta publLehed by Fr£sth end 8p£vey (2) and 8eehofet and Wennberg (3) thee the puff profile Cshape) Luf~uan:es the deLiver£u of a eiKareCte. EarLy peaked profiles tended to increase the deL£vez7 of ~4cot~ reLat~Lve to the TL~ eompouemts, vhereas Late peaked profiles tend to increase the ~eL£very of T~4 c~npo~mt8 reLat£ve to u4cotine. The deL£verLas for other prof41es examined were intarwed~ate. This report describes an expertmmlt to /nvest~pte the main and lnte~t/~n ~fects of puff shape, puff volume ~ interval between puffs on del~ver£es of TPN, n4eotine and carbon monoxide, the rat£os of the 4eL£ver4~e8 of these ~oupononts and she f£1tra~JLon eff£e£ene£ts for T~4 and nicotine. BAT Co LTD - MINNESOTA TOBACCO LITIGATION O c...r't oo O

INDEX HAS INDICATED GAP IN BATES RANGE HERE

-3- ~THOD The ezperismst side use of the puff duplictCor developed in SouCbmnpcoa (1) vbtch nov•ally smokes cigar•Cots Co human 8mokinZ patCezns recocded on paper Cape by the 8mokLnS puff anmlyser (4). Hovever, it ca= be pros:mead ra work as • versatile research smoking engine mul in ChLs emperLmenc special paper capes vere prepared reprcsenclns the specific smoking paccecus co be studied. Further details of the mCJ2od m:e given mc the end of the repocc. A range of puff volumes and incerval~, becveen pu££• were chosen Co cover the ranK• typically observed when human smokers have been sCudled. The puf£ vole•as used we:e 23, 35, 52..5 azLd 78,8 ml mud Che inCez'vals beJ~N~en puJEEe vez-e 19, 33, 58 and 102 eecm:da. Human emmkinll pact:orns ~¢8~/e C~8 range harve beet measured buC msch peCCarst8 may be eona4dered as euccepCional. The puff pro££1ea (shapes) selected fo= ch4a study we:e noC actual human pz'ofiZee. Fot~ shapns, •arly c~iangle, lace ez-iaugle, sine etzz-ve (bell) and square ve=e eouscrucced autcbemACi~tlly Co :ape•sent the main cha~a~Ce=iscics of human p~ofilea. The puff duration was fixed •c 2 seconds and • molcinK paCe•on cepe was consc~scced for each of Cbe eL:ccy-£ou= comb~tct~s o£ oh• above factors (£~,zr shapes, four vole•m, fou= tJzCervals). Each cape cauaiaced of • lone ee=ias ~£~ Ldenc£ctl pu~£s sud iJ~tervL18 used to conL~ol the mokiu~ of Ohm CmmC cigazeCCes ou the dupticaco=. The ctK~reCCe brm=sd chosen for Ohio scud7 m • B.A.T curreut p=oducC£ozt versicm Of 8en8ou & Hed8es ESTT, u4sLch 48 C~plc•l of the k~Lu4 sin• f£1Cel: tipped c~4BareCCes ac present available on the U.K. umrkeC. BAT Co LTD - MINNESOTA TOBACCO LITIGATION %O Oo Q

-F" -1 Y: _.L l,G __..I l o <...,I"7 BAT Co LTD - MINNESOTA TOBACCO LITIGATION

-4- The dlmens£ons and del£veries of this cigarette when smoked under standard conditions are shown in Table 1. TABLE 1 D]D,~.IqSlCOtqS AHD &NA~XCAL DATA FOE THE CZGARET'ZF. SHOKZD LMDER STAHDARD COND'rTT(~qS Tobacco Rod L4n~ch Tobacco Type PL1ter 14mcez~l F£1Ze~, Le~Kch T£pp/-ug Paper Lengt:h Draw Rms£eCance (3.7.5 ml/eee) TFM Delivmz7 NicoC/nt (TI~) Del£very Carbon MouozLde Deltvery Puff Humber is i|isi m (mn) (zm) (am) (,'- v.G.) (uS) (mS) (mS) The ct4s=ette £41te= £s not :mst£1ated. 64 Flue-cured Blend Cellulose Acetate 20 25 12-14 31 1.6 22 9.4 The dup1£c~zor was callbrated and operated as previously described (1) except each c£garette was marked by penc£1 at 28 mm (t£ppLng paper lanKth + 3 un). When the bux~ reached the mark the dupllcacor was szopped mad cbe c£sarat:ce excLngu:fshed. The delivery of T~f was umasured by d~recC w~Khing of the Cmnbr£dge f11Co: pad ~: ice holder. The £ilter C£p was cuC £:om the clsm~eCZe, re, hem f.Z had bees smoked, and ve£ahod. TLpe ware also cuc from 40 unamoked cl4r~reCtee, and an averaSe we£Kht found re: comper£emz v~ch Ohm CLps couca/~ta~ par~Lculate m~tter. Zn this vat 1. mac/mate could be made of the £ilCrat£on df4ciency of the f41Cmr Co T~I. Both the ££1cr8~Lon e£fic£ency for ~ and n£cotine were saC/maced by wa~gh~ on c:J.p x 100 Y.E. - weight on tip ÷ Ve£sh~ c~ pad • mm,...~. C~ .-,.,j BAT Co LTD - MINNESOTA TOBACCO LITIGATION

INDEX HAS INDICATED GAP IN BATES RANGE HERE

-5- The nicot£ne ccmr~tlned in ~ filter tLp and on the Cambt£dSe filter pad ~e measured Is to~al nicotine aLkAloid8 by a 8t~ul~d s~toamslyser smthod. The carboa uonoxide conte~t of the 8as pkse vu meuured as percentage by voluma by an f~frarod gu analysar. The rumba: of puffs drawn from the cLKaraz~e, and hence th8 mmbet of c18s~iuK puffs, ~tr8 noted so that the percentase snd weiSht of carbon mouox£de in the whole smoke could be calculJ~od. FLve rsplic~tes stets smokad for each of the 64 r~pem. The hr~ from the five repl£c~tes were averaKed snd are shown ~n TJbles 2-5. The date for t~e four vo2~es snd £ou~ £acervals 8re 8bc~m for esch of the £ou~ puff shapes. Q ~Tn O %O BAT Co LTD - MINN~TA TOBACCO LITIGATION

INDEX HAS INDICATED GAP IN BATES RANGE HERE