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CO~J3JZZVE TOXZCZTY STUDT OM ~ PROM c~s ~z~G s~msTrru~ ~s l SC " ~ ~ ~ ~ ~ ~l'l~ .u.s.N.m~m~ TOBACCOS (~~ ~0~) R.EI:'OR~ NO. RD. 1.506 ,EESTR~CTED zz..,8.1977 AUTHOI: R. BLnns ISS~..D BY: 5.E. Evelyn rROG...RZF. 11.01.05 o I.S'L"S,.T.r~ZO~, z Dz. S.J. Green Dr. Z.I/. Hughes Dr. R.A. Smxford IL.K. G£bb, Esq. I.S. Wadt, Esq. l.G. H£cholls. Esq. E. Ricte=shaus I)1:. F. Seebofen: Dr. C.J.P: de Siqueira Dr. D.G. FeIton Library Copy NO. i, 2 I| " " 4, 5 IIII tl 6 " " 7, 8, 9 " " 10, Ii " " 12 " " 13 " " 14 " " 15 " " 16, 17 COFY NO. BAT Co LTD - MINNESOTA TOBACCO LITIGATION

INDEX HAS INDICATED GAP IN BATES RANGE HERE

D/Z~,/:~6D Group Research & Development: Cent:re, Bc£c£sls.-.Amer£can Tobacco Co. Led., llchAu4L'u4t 1977 COer~'_~lNG ~b"l'J.~:U~:~ ~S SC, T,,'C, (geporc No. ]LD. 1506 it.escc£cced) SUJ@fAR,Y Zssential detaLls are Kiven of ohm :esults of a larse-scA1e inhalaC£on 8tnuiy carried out to compa=e 8C~ WC and ~ Mark B. Conclusion. drmm as • result of the e.,zpmrinmaC hzv. been 8mma~£se4. Complete details of the cox.:LcLcy study are Zivem in a sepax'sce 0 C~ BAT Co LTD - MINNESOTA TOBACCO LITIGATION

INDEX HAS INDICATED GAP IN BATES RANGE HERE

An experiment has been caz=£e~ out to assess the comparative toxicity o£ smoke from c£ga:ettes coutsJ~L~ ~he sheet mate:~sls SC, WC and ~ Hark 3 (BK). The control c£sarettes used contained 100Z tobaccos oF a standard U.S. blend. Fo= each of the sheet mSCL~iSls be~8 tested, cisL:ettes were made to tazSet f~clusion Zevels of 17Z sad 30Z of the substitutes. Du:~ the ezpe:~t anLmals ~ere exposed £o: & reeks to smoke at eve &ilut£on levels from each of the clSacettes. The ¢ompZete examLn~ciou iuvolved p:ellmlnaz7 assessment oF mate:eels, TI~ dosJJ~tz7 and exce~slve mm~cor~ of exposure coa4£t~oa~. At the end of the main ~o~LcoZogy study the response of lunK tissue Co ¢n~osu~e to maoke fram the VL=iOUS cigarettes was e.zamla~4. On the bas£s of these observations, the relat£ve ~ox~ci~ of smolte from cigarettes cou~f~ins SC, I~C and lie has been assessed. Complete ezperf~eur~l details of tb~e study are presented i~ mn accompan~ng :sport. To alloy a more rapid appra£s:l of the expe:iaumt, this su~aaz~ report co=~s the essences1 points ~r£e~g from the complete to~clL~7 s~ud~. THE CIGd3~F~ES ~L1 three sheet m~l~el:~ls affected ~he basic cha~acte:istics of c~Kazettes. Puff tombs: was alcezed by each of che sheet :mcec£als, wi.ch both WC and pa~CicuZa:17 SC tending to increase puff m~be:, whereas add~;tiou o£ BE to c£Smrettes ten4ed Co reduce puff number. BAT Co LTD - MINNESOTA TOBACCO LITIGATION .(..~

INDEX HAS INDICATED GAP IN BATES RANGE HERE

-3- De£ivery | There yes no affect on ~ del£very of adding up to 30X SC to cleat•tee. WC sheet c~uetd 8 reduction in ~ delivery which, at both /~clusioa levels, was rouKhZy 1A2[ oE ~at from the control elK•retie. B[ caused • prosress£ve reduction 4n TIM dellv~ (7£eure l(a)). TTH delivs-~y from c£satette8 to the an/x~Z exposure chamber was slilhtly 10wex than that from the butt of the a4sarettee, due to daposit£on of putt:uZttt8 in Zhe smoke 8emeration untt (F4Kure Z(b)). 7or each ¢£earette couta/~£nS • 8ubet£tute, the e~mbLuod e~£ects of thanked T~M del£very and pu££, numbe~ o~ ciKarettes caused • reduction in ~4 deZ4vory pex puff. The reduction was the 8mna £rom SC and MC c~KRxettes and Kreacex than the e££ect on this per•meter o£ addLnK BK to tobacco (Yis~re ICc)). Carbon. 14onoxide. ~C0~ Del£ver7 ~atar£•18 SC and UC both had the ef£ect of £ncreu4x~ total CO delivery from c~earettes. The inczease was 84m41a~ [or both sheets at the 172[ inclusion level, but at the h~Khar ~ne~usion level the dfect of SC was more marked. CO del~v@ry from e4Karettes vizh ~K was 84m~Zar to that from ~he con~xol ¢isarette (Y£~e 2(8)). • aeh sheet ~atex~•l caused an increase in CO delive~ pew pu~£, but ~he increase was not cle~xly related to the level o£ ~nelua£on of the substitute mat~£ale. Over•~l, the /x~rease in CO deZ£very pew pu~£ for 8~ the expew~mau~8~ cLKa~ettes was foully ~1~ of ~ o£ the aontrol (FLIp~e 2(b)). T~/ m~d GO del£vewias of cij~e~tes were a~fe~ted to 8 d~f£exent extent by each o£ the sket materials. However, despite these Oh•hieS, and ~he effects of the ~ubg~tutee on pu££ number, the relative del£veri~g of CO and TFH remained constant in ell experimental c~Ea~ettu (TabLe 1). BAT Co LTD - MINNESOTA TOBACCO LITIGATION u

INDEX HAS INDICATED GAP IN BATES RANGE HERE

100:{ TOB 17Z SC 17Z WC 17Z 31~ 30Z SC 30X WC 30:{ BR CO (:s/cis) (.) i .m 1 13.2 15.7 15.6 13.6 18.1 15.9 12.7 CO/'t"l~ ~t£o sxeos .= ss TPM Relative Co (mg/cia;) atb 1OOX Tobacco (b) | 15,34 0.86 1.O 15.31 1.O3 1.20 12.91 1.21 ~,.41 12.29 1.11 1.29 15 • 46 1.18 1.37 13.51 1.18 1.37 11.36 1.12 1.30 The effect of 8ddinl esch of the |heat uater£ats Co ci|a~eCtts vas Co reduce the avetase smoke concentraC£on to which an~ss18 were exposed. SC and gC sheets produced a s~nilar reduction in chamber TPN concentration vhich~t8 directly proportional Co the leveX of ~nclusiou. ]X cue~l a less pronotn~ed buc proporclou.al reclxu:Ciou 4,. averaKe ¢oucentz'aCiou of d£1u~od smoke. The deKree o£ exposure CExpoaure LevaZ) expelr£enced by an~m.,lo Ls related to averaie smoke coucentraClou (~I/£) x ~xposure t/al (= p~tt[£ number Lu~nuCa8). ~dLt£ou of aS1 8heat ~ater£als aC tJ~e 17S £nclus£on level caused a reduction In T1~IExposura Level. This was tar|ely due to the reduced average maoke concentration VtLtch~LshC a18o be accompanled by a chanae in exposure time (SC+, BE~). ][ncreasiLnE the level o£ shear BAT Co LTD - MINNESOTA TOBACCO LITIGATION

INDEX HAS INDICATED GAP IN BATES RANGE HERE