Tobacco Documents Online

1 II I T~:E RE~: ! Sen~ I~te I~te Rec~ Re~-nea 7 s- t, J~hor I~e I~ BU•." Co:~ec%iana Note: I. 2. This ~ foz~a is in%en4e~ %0 £aoi2/ta%o and. ~o~all "the In~rreas oE G.R. & D.C. Re,oz.• *~he ¢rpesc:t1~ m •hill ~e z~xn~ £m Zln:11~ ap];=mm~L a=~ Im~. ~e p:= ~==:a shoula ~e o,'---m~oecl at ~be t~me of the ~t~ ~-p~z~ and aooc~ the ~7~esc=~ (sz~ ~x~ez aftez g:m%i~n) ~t all subnoq~ten% sta4~a. It :=st 'be ee~t to oen%-zal filing with ~.he ma~e: v~e~ %he :epo:~ i8 l~mzed.. h~J~e~q~ l~8ti~le, d-~a~tm f~:~ I~y~:LD~ 8hou~ ~e ~r~l~%e~ in tJ~. lfte= ~yginK, ~e ~euc=t~t 8hmLla no=ally "De :e%~vnea ~o the J~th:=, who will ~8e~:en~ly Ob"~.t~ the Gl-o~1~ Lea~e~m ~ IB~:4~'• &p1~-~r~l. 3. CiTcul~tlon 8houl~ be ae~ezmlne~ ~y the Issue=. 4. The %?'pesc-~l~t muJr~ =0% be l:~ese~%e~ Eo: p:in~in~ ~n~il the Issue: ha~ in/tlal!e~ ~e ~=~ £©::~ S4sl=~ "P~m M~e~". ~. Aft•.- ~_----.%i-~, one bou.~ co~y ~:s~ be re%-~.--ned to the Issuer_ f~r fimJ~! a;~r~r~! a=~ "~he issuer will ensu_-e ~h&~ ~ne copy 18 see= "by "the ~a~•.-. m r~D BAT Co LTD - MINNESOTA TOBACCO LITIGATION

e.,_ BAT Co LTD - MINNESOTA TOBACCO LITIGATION

ATTENTTON ° t tc This york was produr, ed nn the HaKnetic Card type-,'~£tcr. ] "~ 7 ~r [,Le, TL £s ianperative that all corrections, alteratLons, etc., "~ ~ " are made clearly. E.G. pencilled co~s, full-stops could be easily missed. A cross in the margin, in I/a~e with the correction would draw our attention to the insertion. Would you please be kind enough to write large £nsertions on a separate sheet of paper, and no__.~c cut out portions of typed work. This is because the Magnetic Cards differ £roa Papez" Tapes. - C (" f .... I ""b .'T.t ~c~{.~Cc{~- c .'- f'-" p _! f.~ BAT Co LTD - MINNESOTA TOBACCO LITIGATION ~r

BAT Co LTD - MINNESOTA TOBACCO LITIGATION p',o

INDEX HAS INDICATED GAP IN BATES RANGE HERE

A ST&T'rSTZCAL ANALYS'rS OF THE INCIDENCE OF TUMOUR-BEARING ANIMALS IN JANUS EXPERIMENT B6/B7 REPOET NO. RD.1212-R 9.5.1975 ~UTHOE: E.B. Wilkes ZSSUED BY: M.E. Willis PROJECT JOB NO. ~720 DZSTRIBUTTON: Dr. S.J. G=aen C~py N~. 1 Dr. D,G. FalCon 2, 3 Librar7 " " 4, 5 File No. 46D-2 " " 6 COPT NO. m BAT Co LTD - MINNESOTA TOBACCO LITIGATION

EBW/SMH/46D--2 Group Research & Development Centre, British-American Tobacco Co. Ltd., SOUTHAMPTON. 9th May, 1975 A STATISTICAL ANALYSIS OF THE INCIDENCE OF TUMOUR-R~AR!Nn ANIMALS IN JANUS EXPERIMENT B6/B7 (Report No. ED.1212-R) SUMMARY The major conclusions to be drawn from this analysis are:- 1. Using the all-cumour dana, no siKnlficanc difference between the tumorigenic &cnivities of tobaccos B6 and B7 was found, nor did changing ~he cuts per inch s~gniflcantly effect the ~morigenici~y of the condensates. 2. usinE the maliEnanc tumour data, both the B6/B7 effect and the cuts per inch effect were siEn£ficant. 3. AC the dose Zevels used. both condensates (B6 and B7) were h£Khly ~XiC. A. A marked high dose anomaly i8 present in Ehe dana. making it /mposslble ~o compute a tu~origeu/c ratio ~ith any precision. BAT Co LTD - MINNESOTA TOBACCO LITIGATION r',,,o

INDEX HAS INDICATED GAP IN BATES RANGE HERE

-2- 0eJ~CTZVES The objective of this experiment was co assess the effect of two different modes of tobacco preparatlou on the tumoriKenic activity of the condensate produced by ciKarettes concain~nl the tobacco. The e~fecc of various levels of the cuts per inch used durin8 the muu£actuxe of the cilarectes on the tumorigenic activity o£ the conde~ate8 was also Luvestisaced. 2. DESTGN OF EXPE~ Two modes o£ tobacco -~nu£acture, three level8 oF cuts per /~ch, and three levels o£ condensate application warm used, a total oF 18 tobacco/c.p.i./dose level combinations. Thus the experiment co~isted o£ eighteen Stoups o£ animals, each K~roup contai~4n8 8A animals in the ociK~al desiKn, a total of 1512 animals. These animals were unmated female albino mice o£ S.C.I. breed. When submitted to the exper~nenc they were 8 to 9 weeks old and weiKhed on averase 20 $. The three l~els o£ cuts par inch used were 30 c.p.i., 60 c.p.i., and 120 c.p.i. The ~hree condensate dose levels used were 25 mS, SO m8 and 75 mK. The condensate gas applied every Tuesday, Thursday and Set.day throuKhouC the period o£ the exper~nt in 0.3 ml o£ solution. &11 animals in the exper/ment were shaved with the same sbearln8 rhythm. The details o£ an~m61 husbandry and condensate production are to be found Ln (I). 3. RZSULTS OF ~CPEKZMEHT The practice at 3details, Fra~kJurt~ is to exAmlne each annual weekly. Skin lesions ~rith~n the painted area are recorded as azure /~ they have a diameter o£ at Isaac 2 m and protrude above the 8kLn surface or have a firmer consistency than the 8urroundin8 skin. BAT Co LTD - MINNESOTA TOBACCO LITIGATION t..J-I t'~ ",O OO

INDEX HAS INDICATED GAP IN BATES RANGE HERE