Tobacco Documents Online

]WJrI"I~CTED Re£eu:emce No. B2o 3 Rese•=,_-'n Con~o=enoe, Cau~clt- &ue~st, 3.982 IIqDrJIqST~DZl~G THE 8MOK.--HG lnROCL~5 -- W~Y FO~ FOR ~ DELI"VtRY PltOI:)OCTS N. OldmaA Zn response 1:o c:onsuautz" demure4, we h•ve been emgaged £or some oaeusJ.derable 1~ the deve3.op=umt and mau:ko~t.ng of ed.garettes w£~.h :edttoe~t smoke dellver£es. 3Products have been imoi41jTJl~ed ~or P..host of otlJ~ OOVtBMMIrJ MhO, vh4180 vJ.sh~ng to remsJ.n ¢~=00~0 smo~ers, ~r~4ye ~e ~rlon~ hu~£4t fz~m muo~ng c4garo~tes y£el~g 1088 ~: 8n4 n£cotLno than £s ob~ad from • Re more ~a~o~al p~u~. So ~i~on 100 the new c~ttas aooempan£e4 by ~lhe n004 for t:he smoker t:o 8d~eullt hLs expecl'a~ons, jF6x~4~-u- 1:tr1¥ £n z~tspoc~ of /'.he emA~.~.s£a~t~Lon" cr: ~asS:e level w}t£ch he wJ.11 ob'caL-~ fz~m ~e: ~l£ve~ pro~hz~. For those ~o are" ~10 ~ a¢cmmaodate the z'odXlct:Lon In serusoz7 and l=harmaaolo~r~al 80JJmla~.£0n, 4t= 48 assumed tha~. the J~p14eu5 reasseucancm which they ob'c,a~ £z~m smo}clng lmwnr deZlve:~ p:ro4uc'~s ena~b100 -,.hem to remain members o~ the smoking popu~at£0n. ~z=~nen~l~ 4~o Re low do14~ 8e~r, f~ to do 8o, ~en ~e nuamz~s .a~np~s ~£th ~ va=£~y of m~14er pz~4~c~a. Th~ ~he~ are • ~~n~ I=o 8~:Lt~h ~01¥ 1u~4 c~as • 8£~4££~an~ ho•lth concern ~v•~£0nr that: they £•£1, ~£4es 80me 84gn4£Lcan~ p=oducS: weaknesses. G~en ~o •~z~nt=l~r h~.~ lev•l of unsu~=essf~ lon~te~m s~£~ez~, £~ ~ea8o~le 1=o concl~ that ~o ~th ~ononrn~ (but as yot unsa~£8££ed) smoke= ~=~ses • market, se~= with 8~££cant ~ po~Lal. @ IN2 Itd~r~ Ammlma Yebeem C~ L~ Tld= mere 0m be •0pied w ~m~u tn emmbeebed peu0m. c --y. C~ O" C~ BAT Co LTD- MINNP.~OTA TOBACCO-I.IT--I-GATION ~"

o Xn order ~ providt F:o~uc~8 in ~s JJtpo~t ~tteg¢=~, Lt v~l be ntees- 8az~ to devote considerable roJo&rch reso~rau to s£gu~f~can~l¥ ex~end our u~de~s~snd~ng of the var£ous se~u;a~Lor~ a~soc~ated vA~h smokAng. Xn v£ev of ~e mul~-£aceted natu=e o.~ ",.he phenomena to be stu~edt At As app=o- p~£ate that ve conceAve of an holAstAc approach to research An th~ area, • drawLng ~pon resources from a ~nge of ~esearch groups with ~GDC. Such a ¢o-o~a1:ed ::ese~rch pl~:~Fram~ :Ls berg ~nmtx~ed fz~m oncjo~n~ pz~:jec1~s, each of vh:L~ As likely to p=ov44m 8Agn~ioant contrJ~uS~Lons ~:o ~ ~dLer- standing o~ ~he ~o~y~ c~emi~a~, physAolc~A~al and phLwmacolc~Acal re~u£rmn~ for a~var~ed 3~w d~]~Lv~ pL~lu~. Xn orde~ to e~ablA~h ~.he ]~m~£~ of any new concep1~s or 4as£~as, refine-" men~ and ex~ensA~ of our c~M ~Lng and ~mokAng behav~ou~ m~hods w:LI~I. -.).,so be =eclu.~e4. Xn essence, v~ ~ ~on£ronted by ~e nm~d 5Co ob~ma£n f~o~ mma~1 8mounts of Smoke, the ~ 8emsoz~ and pba~m~co~i¢&l me~Ja~Lons, we a~e moe~ng eo ach£eve enhanced ~fAcAenc? of[ ~a~Lon, on • per cAgace~Ce or per pu~f~ basis, ~n order that the maximum sensa~Lon can be achieved at ~he ~Lo~es~ delAvmrM level - "~a~Ang the Smoke work ha:de='. &C ~e same l=Uae, ~he smoker must k able ".~ obl~n h:l.s salr~s~ac~A~m v£1~ou~ "vo~'k.,tng ha:de:" - by "ove:smokAng" oz" &~temp~Lng ec~mpensa~LonO. In c~de~. 7.0 achAeve ~h4s~ vo need ~ :~=o £~l~Ly ~m4e=8~=a~4 (a) ~he mechanisms ~.h~gh ~Lch :ensoz7 and ~haz~ncolog4cal 8~1s are :ece~Lved# ~-un~ed and t~anmla~od~ (b) (c) ~he ~ponen~.s of 8moke wh£ch yAelfl ~hese seusa~Aons and vh4ch of ~ue are amenable" to W~Lfa~atLon o: 8ul~lmnentat~on~ (el) ~he An~erac~Lon ~e~veen produ~c ch~=a~e:£st£cs, s~ok.lng behav£ou~ (especAally p~ff 5~Lng) and produ~ ac~eF~abAiA~y.. All these fa~*.ezs v£11 have I=o be :e~oncAle~ ~Lth t~he smoke:': Lnhe:en~ ..dAsposi~Lons ~ smoke An a l~az~Acula= v~y - la:gely dete=n~ned by ~As expeziwnce o~ ~a41~Lonal, £~Ll-£Za~ou:e4 p:~4~-I~ Which 4e£Ane, a~ leas~ An ]pa~t, ILLs mx]pocs~Aonm of • deaA:a~le and accep~tble stall,Lag ex~er£en~e. 0~: i~.--~e: ~mde~s~an4An~ o~ I~e mk£ng pz~m8 w~11 ~IL=~ • roach olose: exa~Lna~Le~ of ~he mm~Ang a~c. Zn ~a=~.teula=, the =ole of l~e ea=ly mm~at=Aons J~t t~t mm~h, vhich ~ont~tJ~e .~o l~e =mmke:'s Amp=ess£em of n~Is£acS~Lon. We believe ~'ta~ goo~ ~mo~Lng ~at~Le8 8~e a pre_-~[ulsLte of an accel~le smoking eXl~=Aemcer ~ do ~ yet ~ whether the J~po=- =e~s~t~Lon o~ "mmz/~d~Ll" £s ~nfe~ by £em~u~es 0£ t~e maoke ~=l~s or is i~fe~ce4 t=~-~:mgh ~e~Lating 8ensm~Ao~s. We bellev~ ~h8~ ~e "]bo~e 0£ the mmok8 may'~ ~em~Lr.a~ly em~tn~ ~.sJ.Dg, £o~' ~1~: £a~ a~td es~.~= e~UL~v~sr ve do ao'c k~c~ h=v theme chmm~28 8c~Leve ~3~L8 e££e~. We believe 1~a~ ~he rome= expects • mu~J~ meusoz~ an4 1~ham~mlc~LrJ.1 rm~d for a g~ven pu~f4-g &ffo~, but ~ do no~ kno~ the ml&s~L~ ].~.ltk of ~J~Ls =o==el~1~Lo~. 1911~ Ik)h~ AmaJus Teteeso Cz LaL TIb mm mle c0pted ~ 8j~mu t0 ummjl~4~d waee~ ~mmm m BAT Co LTD - MINNESOTA TOBACCO LITIGATION

.. -3- Here .epea4£L=al/y, we need to know much moz~ abo~ ~.he rela~Lonshtps between smok£nv beh&v£ou: (especially puff. taJ~Lnq) and ".he seneoz~ evalua~Lcm of 5".he same ~LgaxT~tew £n o=de~ t.hst we Imy 4dent4£y 1:he behav£oural and perceptual c~msequenaos of ~cuJ.ar 4es£gn changes. &t ~ same ~.lmo, we need to 1:~re~l:~Lga~o ~h@ L-o].a~Lo~.sh£p )~wten 17uJ~£ takAng and Luhal&~.A.ou, £n o~ to kdon~.A.£y genuA.ne mouth-.oe~y ef£e~.-~',s ~t.£=h may Is@ ~pa~nt@4 £zmn 8eussa1:.t~ cm1¥ /J~£eurred from t~.he ).a~.er jphazmao01odr~oal response to £nhaXaS~Lon. We need to 3mow mu~h more aleut the JJ~luence of parS~L~Le ~Lze and aez~dynaml© e££e=ts o£ smoke Ln ~:he mouth, J~ o:~ler ~o detez~lne th~ 81~5~L8~ and ~n]. ~=mponen~ of ~m~). 8~Amula~Lon and ~elr ~on~~ to sensory 8~s£at.L~n. We should have rega=d no~ only ~.o 4J~e~ enhanc~men~ of des4rable 8ensa~Lons, but also ~o the m4~&~1¢m o£ und~s£nble se~sa~Lons. Zn ~h~s conr~e~cnt, ~l~1ohex~l alcohols a=e claLmed ~o £nh:i..b£~. malodou~ pe=cept:l.on. A~ ~ha name ~Lmo, we should e~plore ~ho poss4ble ~].o£~t~Lm'~ o£ me=benZene vt~Lch m~ po~ent£e~e des~raJ~Le z~sponses ~o smoke ~t~L~uen~8; £or emample, the z~le of sa14vn~Lng agents, 1J.~e mu~'~so oc=t~-a~et~te, should be ~u:the= £nvea~Lgstu4. Zn e=~mazT, on= £u~ure z~sea=ch pro:Je=~s Ln th£s a=ee w£11 re£1e~ on= ~t~ment ~o be~5=e= understand ~J~ smoking p=ocoes ~i~ ~ be1£e£ ~het thJ~s w/.).1, pr~r4de us 5rlt.h the moan8 to deusAgn and nell lm~ del£vet-y Im~4~s ~ • smrk~ va£~Lng ~o be ~onv~n~ed ~,.hat ~.~: Ls pmssJ.ble ~=o smoke ~m~Lld" e~Lge=e~-es v:L1:.ho~t: 8a~=~££4cLng ss~=4s£~-~Lon and en~ol~em~.. z'eseaz'~t vJ.1], not only, en'~end ~ren~ p~ de~t~Lopment: p=£nc£ples, Is expe~r.e~ to pz'o~rAde soma em~-el¥ new d:LmeneAons ~o our ~)~Lng aJ:<~L~ ¢£gaz~:t~e 44sJ.gn, Zn lmrSu.~tg ~hese goals, we need ~o know ~:i.c~ 8¢~.~v£'~Les £n o~hnr CA~ :0m~=h laboratories have a ~Lroc~ bea~Lng on this ptogz-anme and on whJ.~h upecr.s 8ooue d.5.z~=T, collnbo=atJ.on might= be ar~ang~, Also, we should ask wlh.i.ch othe= Xabor&tor£es/oper~ng ~spa~Les are ~ble to of£e: £a¢411t£ee I=o ££e].d t~st ,tJ.Sp~J.~a~t 6~velopmem~=s a=~sLng £:om thOLe .o 4~ o o IMI2 lid~h Ammlma Yeimmo C~ LaL TI~ me~ =m be ea~mi w ~ w u~ulhe~i pma~ BAT Co LTD - MINNESOTA TOBACCO LITIGATION C~ O',, c:r,,,