Tobacco Documents Online

Meeting at The Council for Tobacco Research New York~ New York April 20-23, 1982 During the period April 20-23, 1982, two important meetings were held at The Council for Tobacco Research (CTR): I. Meeting With Microbiological Associates (MA) Representatives, Tuesday, April 20, 1982 The Scientific Advisory Board (SAB) met with MA representatives as noted above to review the status of final report preparation for Contract 30. Experimental work was terminated by mutual agreement effective June 1981; final report and data transfer were scheduled for December 1981. Details of this meeting are shown below: Persons present were: Microbioloqical Associates • Carol J. Henry, Ph.D. Richard Eouri, Ph.D. Scientific Advisory Board Richard M. Bing, M.D. Henry T. Lynch, M.D. Drummond Bowden, M.D. Leon O. Jacobson, M.D. Joseph D. Feldman, M.D. William Gardner CTR Staff Robert C. Hockett, Ph.D. Robert Gertenbach W. T. Hoyt Vincent F. Lisanti, D.M.D. David Stone, Ph.D. Donald H. Ford, Ph.D. Industry Technical Con~mittee Preston H. Leake, Ph.D. Drs. Richard Kouri and Carol Henry su~arized the analysis of data which had been collected over the past 10-12 years and required the expenditure of about $13 million by Microbiological Associates. An outline of their presentation is enclosed as Attachment i. Details are included as Attachment 2. (Note that the last stapled section of Attachment 2 titled "CTR 101A - Chronic Exposure to BC3FI/CUM Mice to 2RI Cigarette Smoke - Second Draft Analyses", with pages designated A through N, represents a more recent analysis of this study.)

-2- Comments included in the agenda material for this CTR meeting revealed that Contract 30 to MA was extended from December 31, 1981 to February 28~ 1982 at a cost of at a cost of $34,000 of unexpended funds remaining in this contract. I understand that this additional expenditure was approved by CTR in response to a request from MA personnel during a presentation at CTR earlier this year. Additional support for data analysis is now being requested by MA (See Attachment 3). Subsequent to the meeting with MA representatives, Dr. Lisanti drew up, for review by the Scientific Advisory Board, a proposal for further contract extension. Emphasis was placed on proper statistical analyses of work already completed. This extension is intended to be the last and MA will be directed to complete analyses and summary of all experimental work. (See Attacb/~ent 4) The work completed by MA is judged to be unique and is likely to engender critical responses by the scientific community. Accordingly, the SAB was especially concerned to have a good statistical analysis reported by the primary investigators. II. Scientific Advisory Board Meeting, April 21-23, 1982 The regular spring SAB meeting for review of grant applications was held as noted above. Those present for this meeting are named below: Scientific Advisor~ Board Richard M. Bing, M.D. Roswell K. Boutwell, Ph.D. Drummond Bowden, M.D. Michael J. Brennan, M.D. Joseph D. Feldman, M.D. William Gardner, Ph.D. Leon O. Jacobson, M.D., Henry T. Lynch, M.D. Gordon H. Sato, Ph.D. Sheldon C. Sommers, M.D. CTR Staff William D. Hobbs W. T. Hoyt Robert Gertenbach Robert C. Hockett, Ph.D. Donald H. Ford, Ph.D. Vincent F. Lisanti, D.M.D. David Stone, Ph.D. Others P. H. Leake, Ph.D., Chairman, George Shafer, LeOnard Zahn, Industry Technical Co~tmittee M.D., Medical Consultant to the Tobacco Institute Leonard Zahn and Associates

-3- of the 66 applications considered by the SAB, 42 applications were approved, two were deferred, 21 were not approved and, on one, there was no motion. In this last instance, the applicant proposed studies of specifically identified cigarette brands. Some information on the applicants, titles of their proposed studies and costs, as well as a sD/~mary of action taken by the SAB are included as Attachment 5. General Comment Matters ran very smoothly during this meeting. Dr. Jacobson, with support from Dr. Sommers, chaired the sessions so as to promote open expression by each member of the Scientific Advisory Board. There was good interaction among the members. I was particularly impressed to find that individuals who had recently become members of the SAB became actively involved in the formal review of grant applications and in less formal discussions during breaks. Evaluation of applications proceeded expediously and in an orderly fashion. I also note with pleasure that Dr. David Stone appears to have fully recovered from the surgery mentioned in my previous report; he was present and active during this meeting. The Fall meeting for review of applications is scheduled to be held in New York on October 6-8, 1982. For information, copies of each of the following two publications are included as Attachments 6 and 7. #6 - "Characterization of Human Expired Air: A Promising Investigative and Diagnostic Technique", Boguslaw Krotoszynski, Glenn Gabriel and Hugh O'Neill, IIT Research Institute, Chicago, Illinois and M.P.A. Claudio, Mercy Hospital and Medical Center, Chicago, Illinois #7 - "Measurement of Chemical Inhalation Exposure in Urban Population in the Presence of Endogenous Effluents, Boguslaw K. Krotoszynski, Geralynn M. Bruneau, and Hugh J. O'Neill, IIT Research Institute Chicago, Illinois