Tobacco Documents Online

4 w a AMERICAN HEALTH FOUNDATION NAYLOR DANA INSTITUTE FOR DISEASE PREVENTION Dana Road, Valhalla, New York 10595 Telephone: 914-592-2600 American Health Foundation ^ . 320 East 43rd Street New York. New York 10017 o Tslephone:212-953A900 David J. Mahoney, Chairman Chairman and Chief Executive Officer Norton Simon, Inc. William J. Levitt, Past Chairman Founder-Chairman Levitt & Sons, Inc. Ernst L. Wynder, M.D., President John 0. TwPname, Managing Oirector OFFICERS AND BOARD OF TRUSTEES ~ - Eric M. Javits, Secretary ~ Senior Partner Javits & Javits ~,.. -" TRUSTEES: 4 John ~J. Burns. Ph.D. Vice President for Research ~~ - Hollmann-La Roche, Inc. } - ; Thomas L. Chrystie Chairman Merrill Lynch White Weld Capital Markets Group = Theodore Cooper, M.D. Dean Cornell University Medical College M'ra. Charles A.,Dana D. Ronald Daniel Managing Director, McKinaey & Company, Inc. Ralph Landau, Sc.D. Chairman & Chief Executive Officer Halcon International~,Inc. Hildegarde E. Mahoney Bruce S. Nevina 3 + President ar, Perrier, Great Waters of,France, Inc. E1 Joseph Robbie Managing Partner ~ ' -Mit<mi Dolphins, Ltd: : Han. Donald H. Rumsfeld r, PresidenY& Chief Executive Officer 13.D, Searle & Company John W: Simmons :' Presidenf& Chief Executive Officer ; -_'Morton-Nbrwich Prodbcts, Inc. Mra. Jennifer Jones Simon Thomas A.,Wataon ADM. E• R. Zumwalt, Jr., USN (Ret.) ~, President & Chief Executive Officer American Medical Buildings, Inc. David L. Davies Axeoutive Vice President John H. Weisburger, ftD. Vice President for Research ; Naylor Dana Institute Charles B. Arnold, M.D.,,M:P.H. Vice Presidenl for Research Health Maintenance Institute -~ }Y _ I f r, . December 10, 1979 Dr. Thomas S. Osdene Phil'ip Morris U.S.A. P.O. Box 26583 . Richmond, VA 23261 Dear Dr. Osdene: Noting the date, I would first like to congratulate you on your 42nd birthday. A1l' the best to you. Please find attached our data on the multa- genicity of the smoke condensates A and B, and their fractions. Except for the muta- :,genicity of the basic fraction in TA 98 and TA 1538 with the S-9 liver fraction of rats pre-treated with 3-methylcholanthrene, we cannot find any differences in the acti- -:vation of tars A and B(°tars° were those 'you sent us for the mouse skin bioassay). At this time we cannot assure you that the two differences are real or based oin weak- nesses in our separation scheme or aging of the "tars". -We may repeat the test for these two examples with tar freshly genera- ted at AHF from the two cigarettes. Please let us know.your thoughts on this. One finding which we wil] reevaluate in due time, concerns the relatively high mutagenic activity of who1e smoke condensate of ciga- rette B at 25 ug/plate i!n TA 1538 with the S-9 0 .fraction of rat liver•homogenate induced by ~ 3-methylcholanthrene. rA W r _ . aq4f+~;'.a~, L Fa , V J. iP w:

n ;e NAYLOR DANA INSTITUTE : kr DISEASE PREVENTION 1; .Page Two December 101, 19'79 Currently, we are testing the "tars" olf the 14C-labelled cigarettes and the fractions for mutagenicity. ; With best wishes, Dietrich H'offman DH/cch Encls. 9, r . .. r4[YR+.:' . . i .n'.:[`l,ii._. -/ t....~~' -. ti CC: Dr. E.L.'Wynder Dr. E.J. LaVoie Mrs. I. Hoffmann ~:DrF R, Seligman, Philip Morris U.S.A. .y. ti O ,.~. ;, W J

~.~ iV 11L .. ,