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NAYLOR DANA INSTITUTE 'for D3SEASE PREVEN7"0ON American Health Foundation Dana Road Valhalla, N. Y. 10595 Tel: (914) 592 - 2600 Mne.ican Health Foundation 1370 Avenue of the Americas New York. New York 10019 Tel{ (212) 189-8700 OFFICERS AND BOARD OF TRUSTEES David J. Mahoney, Chairmen Chairman and President Norton Simon, Inc. William J: Levitt, Past Chairman Founder-Chairman Levitt,3 Sons, Inc. Ernst L. Wynder, M.D., Presldent Eric M. Javits, Secretary Senior Partner Javits & Javits WarnerG: Cosgrove, Jr., Treasurer Vice President-Director Shields Model Roland. Inc. TRUSTEES: John'J. Burns, Ph,D. Vice President for Research Hoffmann-La Roche, Inc. Thomas L. Chrystie Senior Vice President Merrill Lynch d Co. Inc. Mrs. Charles A. Dana D. Ronald Daniel Managing Director, New York Office MeKinsey & Company, Inc. Ernest 8. Howard, M.O: RaferJohnson Vice President/Public Affairs Continental.Telephone Service Corp. Ralph Landau, So:D. Chairman & Chief Executive Officer Halcon tnternational, Inc. Hildegard E. Merrill Joseph,Robbie. Managing Partner Miami Dolphins, Ltd. John W. Simmons Presldent.d Chief Executive Officer Morton-Norwich Products. Inc. Mn. Jennifer Jones Simon Marvin S. Traub President Bloomingdate'sThomas A. Watson Chairman. Lincoln National Life Insurance Co. AOYiA E. R; Zumwalt, Jr.. USN(Ret.) April 19, 1978 Dr. Thomas S. Osdene Director of Research Philip Morris U.S.A. Main Complex Commerce Road Richmond, Va. 23261 Dear Dr. Osdene: oK . %41- Q o~' ' Xr ' If you agree on this, our veterinarian feels that the Charles River CD-l(1CR)BR mouse is the best strain for our proposed study. Delivery time is such that application could be started four weeks after we have decided on the protocol. The prices noted on the enclosed list may be outdated. Sincerely, Dietrich Hoffmann David L. Davies Executive Vice President John H. Weisburger, Ph.D. Vice Presidentfor Research. DH/ch cc: Dr. Mrs. Dr. ~ E. L. Wynder C I. Hoffmann G J. Silverman C C r;T ~ Research Unit of The American Health Foundation

COBS®R MICE (Cazsarean-Originated, Barrier-Sustained) CHARLES RIVER CD =-1 (Outbred Aibino) In 1959, this stock originated from caesarean sections on HaM/ICR (Hauschka and'Mirand-Roswell Park Memo- rial Institute-Swiss) mice. Initial caesareans, delivered aseptically in sterile plastic isolators, were suckled on foster germfree stock. Nucleus stocks expanded into the most extensive COBS®'production in the world-animals free of commoni infections and'disease. This was the foundation for the building of the "better mouse." CCI: COBSO CD°-1 (ICR) BR CDV-1 GROWTH CHART UP TO 42 DAYS OLD: 1000 or more .56 ea. 500 through 999 .60 ea. 200 through 499 .62 ea. 100 through 1199 .64 ea. 50 through 99 .68 ea. Less than 50 .71 i ea. Retired Breeders .60 ea. Littermates, 21idays old only .78 ea. GRAMS 37 36 35 34 33 32 31 3D 29 28 27 26 25 Additional charge ofS3,00 per box applies to the following; 24 Order of $25.00 or less. Littermates„Retired'Breeders. 23 Protective Filtered'iShipping Crates are$3!00 each. 22 2> Birthdates furnished upon request~at no charge. Six weeks and older add.14 per animal per week. SURGICAL SERVICES (Including cost of animal): Shipped in filtered~crates only Adrenalectcmies 3.60 ea. _ Castrations 2.30 ea. Hypophysectomies 3.60 ea. Ovariectornies 2:30 ea. Thymectomies 7.25 ea. SPECiALIZED MICE: Shipped infiltered crates only Lactating mouse with litter 8.00 ea. Timed pregnant 4.00 ea. Untimed pregnant 2.85 ea. 20 19 18 17 16 15 14 13 12 11 1° 11- 21 s 28 35 t 42 DAYS ol,D 4 i a 49 i . 56 Please Direct All Orders for Mice to: The Charles River Breeding Laboratories, Inc. 251 Ballardvale Street Wiimington„Massachusetts 01887 Telephone: (617) 658-3333 Telex: 94-7433; Cable Address: CHARIVER ~ rms: Net 30 Days, f.o.b. Shipping Point 0UU0i3U0z;2 CRBL-1109; effective July 1, 1977 Prices subject to change without notice