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NAYLOR DANA INSTITUTE or DISEASE PREVENTION American Health Foundation Dana Road Valhalla, N. Y. 10595 Tel: (914) 592 - 2600 American Health Foundation 1370 Avenue of the Americas New. York New York 10019 Tel: (212),489- 8700 OFFICERS AND BOARD OF TRUSTEES David J!,Mahoney, Chairmen Chairman and President Norton Simon, Inc. William J. Levittl Past Chairmen. Founder-Chairman Levitt & Sons, Inc. Ernst L Wynder, M.D., Pres/denf. Eric M; Javits„Secretary Senior Partner Javits & Javits Warner G. Cosgrove. Jr., Treasurer Vice President-Director Shields Model Roland. Inc. TRUSTEES: John J. Burns, Ph.D: Vice Presidentfor Research Hoffmann-La Roche, Inc. Thomas L. Chrystie SeniorVicePresident, Merrill' Lynch & Co. Inc. Mrs. CharlbsA. Dana - D. Ronald Daniel Managing Director, New York..OHice McKinsey & Company; Ihc, Ernest B! Howardi M.D. RaterJohnson Vice President/Public.Affairs Continental Telephone Service Corp. Ralph Landau, Sc.D. Chairman & Chief Executive Officer Halcon Ihternational„Inc.. Hildegard E. Merrill JosephAobbie Maneging.Partner Miami Dolphins, Ltd. John W. Simmons I President & Chief Executive Officer Morton-Norwich,Products. Ihc. eara. dvuru- -nesaimon April 19, 1978 Dr. Thomas S. Osdene Director of Research Philip Morris U.S.A. Main Complex Commerce Road Richmond, Va. 23261 Dear Dr. Osd~ene: Please find enclosed three copies Modified' Proposal for the testing. of our The question arose between the three people at AHF aware of this proposal as to whether we should test the ad'di- ti ve al one as compl ete_ ca_rcin _o_gen, tulmor initiator and cocarcinogien on mouse skim. We estimate that these subtests could be completed with 100 mice each,within six months (tumor initiator) respectilvely, withi'n 15 months. This point is made only on a discuission basis without us having a strong opinion either way. ~ ThomasA.Watson We will be available to meet with you, Chairman Lincoln National Life Insurance Co. a t w h a t ev e r te i me i s c o nv e n i e n t f o r yo u,. Marvin S. Traub President Bloomingdale's ADM E. R:Zumwalt„Jf., USN(Ret.) David L. Davies Executive Vice President John H. Weisburger, Ph.D. Vice President for Research after April 29th. Sincerely yours, Dietrich Hoffmann DH/ch Encl'ss cc: Dr. E. L. Wynder Mrs. I. Hoffmann / l _ Y i`uG. +search Unit of The American Health Foundation