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AMERaCAN HEALTH FOUNDATOON NAYLOR DANA INSTITUTE FOR DISEASE PREVENTION Dana Roadi Valhalla, New York 10595 Telephone: 914r592=2600 C 0 P y American Health Foundation 320 East 43rdiStreet New York, New York 10017 Te lephone: 212-953-1900 OFFICERS AND BOARD OFTRUSTEES David J. Mahoney, Chairman Chairman and Chief Executive Officer Norton Simon,i Inc. William J. Levitt, Past Chairman Founder-Chairman Levitt & Sons„Inc. Ernst L. Wynder, M;D., President John D. Twiname, Managing Director Eric M.,Javits, Secretary Senior Partner Javits & Javits TRUSTEES: John J. Burns, Ph.D. Vice President,for Research Hoffmann-La Roche„Inc. Thomas L. Chrystie Chai rman Merrill Lynch White Weld Capital Markets Group Theodore Cooper, M.D. Dean Cornell University'Medical College Mrs. Charles A. Dana D. Ronald Daniel Managing Director, McKinsey & Company, Ine: Ralph Landau; Sc.D. Chairman & Chief Executive Officer Halcon International„Inc. Hildegarde E. Mahoney Bruce S. Nevins President Perrier, Great Waters of France, Inc. Joseph Robble Managing Partner Miami Dolphins, Ltd. Hbn, Donald H. Rumsfetd President & Chief Executive Officer G:D. Searle & Company John W. Simmons President & Chief Executive Officer Morton-Norwich Products, Inc:. Mrs..Jennifer Jones Simon. Thomas A. Watson ADM. E:,R. Zumwalt, Jr., USN (Qlet.) President & Chief Executive Officer American Medical Buildings, Iha. David~L.,Davies Executive Vice President John H. Weisburger, Pti,D. Vice Presrdentfor Research NaylbrDana Institute Charles B. Arnold, M.D:, MIP.H: Vice President for.Researcn Health Maintenance Institute December 19, 1980 Dr. T. S. Osdene Director of Research and Extramural Studies Philip Morris U.S.A. Research Center P.O. Box 26583 Richmond, VA 23261 Re: On the Selective Reduction of Tobacco Specific N-Nitrosamin'es from Cigarette Smoke Dear Dr. Osdene: In connection with the captioned protocol (copies attached'), it is further understood and agreed's as follows: (a) The American Health Foundation (AIiF) grants, assigns and transfers unto Philip Morris all right, title and' interest in and to any inventions and applications thereof aris- ing out of the services to be rendered by AHF pursuant to said protocol; (b) AHF agrees to execute (or have execu- ted by its employees) any and all papers necessary to effect the foregoing; (c) AHF reserves the righ~t to determine in its sole discretion - whether aaid if to publish the results of the study which is the subject of the said protocol. Notwithstand- ing such unlimited right, AHF agrees to pro- vide Philip Morris with a copy of any paper prior to its submission for publication for their review;

NAYLOR DANA INSTITUTE for A37'SEASE PREVENTION C 0 P Y Page Two December 19, 1980 (d) Nothing contained herein shall be construed as creating a partnership or joint venture relationship between the parties. If the foregoing is satisfactory to you, please so indicate by signing and returning to me the enclosed copy of this letter. d Klarb`Er RK/cch Encls. (3 copies of protocol + copy of letter) S, .