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Environmental N-Nitroso Compounds Analysis and Formation Nitrosation of Nornicotine in Gaseous Mixtures and Aqueous Solutions

Date: 19760000/P
Length: 11 pages
00267984-7994
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Abstract

Author: Bogovski, P. Davis, W. Dunger, M. Griciute, L. Neurath Pein, F.G. Walker, E.A. Data includes: 1. NNN formation from nornicotine in gaseous mixtures of oxidizing nitric oxide. 2. NNN formation from nicotine in gaseous mixtures of oxidizing nitric oxide. 3. Procedure and results for the velocity of nitrosation of nornicotine in aqueous solutions at different pH values. 4. NNN formation in 0.2M buffer at various pH values. 5. NNN formation in 1.0M buffer at various pH values. 6. Effect of pH on rate of nitrosation of nornicotine.

Fields

Type
Chart/Graph
Psci, Scientific Publication
Keyword
formation
nicotine
nitrosamines
nitrosation
NNN
nornicotine
pH
Location
cd 4
Team
nitrosamines
Author
Bogovski, P.
Davis, W.
Dunger, M.
Griciute, L.
Neurath
Pein, F.G.
Walker, E.A.
Copied
Bell
Named Person
Bodenstein, M.
Gmelin
Grelin
Hoffmann, D.
Klus
Kuhn
Lijinsky
Neurath
Singer

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Page 11: oki20e00 Log in for more options!
236 Wl,'RA-:rr; F-z AL. At longer- gea`bioF'£ -timees_ 2t :.oE:is aia~ r.~~iC, [ izr€ appear to _~re- C~ ~ maximai corregponding-io two, d;f -fferes~y paths- Of reect3on, ==howeverE *his finding was not purs;•ed further. Tl.e reaction proceedeti= f ast-e; at- A0aC: after f ivA minutes at pH 3.8 seore than 1% o€ -the nicotine had already reacted, the t ighest- vall€;es ob= - gerveo being reached after two hours when 6.49% NNN were €orm-ed O"Table 4). AOM9MGMaftS Ihis study was supported by US_Counci3 for Tobacco T Research G-raot No. 891.- REFM°..~ .BodEnsteio., e€. (19185 D:e Geschwir.3igk6it der Reakt!on- zwischan Stickoxyd und Sauerstoff. Z. Flekitmochem., 24, 183 . I i @egi Saaat canneJ_ . f rankft. toxic T py.ro1E (Croab3 been re i3uatch 4 CC~.+tent that it _ f oV{. ~ii - pie Elus, B. So Kuhn, B. (1973) Die 3estimmuog dgs Noroiko*_inaitrosamir-es it Rauc,hkondensat nornikotinreicher Zigarecten-. FachZ. Afitt. 3statr. amines - that Pr RNH2 4- 1 Tobak-regie, 14, 231-657 Lijioicsy, W. & 3inger,-G.M.- (1975) - Fomotion of nitroeamirwes from terti-rr=y tmin€s and ritrmis goid'. In: Bogavski, P. & Walker, E.A., ed., N- Aitroso-Compo-zz-16-in the -Artviran-ert,- Lyoni Ir_[e_rnatsonal Agency for Research on Cancer (IAPC Scientific PubUoationa No.9), pg= 111-114 - ~-_ the car catalyi and _tak Saaherri - alao Pr Io4ua,= 1n oeut Ueefer aairea dealkyl ~-= Gkielio (1936) - Ean&woh der or-org~:~.azhen Cletanie, B.AuE1 ~ 4Si, Wyir-.heiz i p. 738 Hoffmann, D., Hecht,-h.ti., Or-nai, R.-ni_ & Wynder, E-L_. (19,7411 V-NitEoso- -nornico=in€ Io tobacco,. - Science, 186, _26Sg426? 9offma^n, D., hachka-m; ; G. & Liu, Y.`I. ;137 5-) Che?%caf tt-.4di°s or. -baccco ar.-noke. XXV%. _On the isolation _mand i(Ursf:,ficasion of t5alriile ard? nor- voWil&e N-ritroemi_rZnea mid Yydra.z yna$ in cigewatte ~-~l:,e. Inc Bogavaki. P. & Walker,_E.A.,- ed., N.Nitrwaac, Cbwwwnde in _ the E?wirowe:}tc, Lyon, International -444mcy for Research on-^ailcer (l~?; Se_::entifica Pt:VFica= tio,`a8 No.9) 3 pp.-1S9-l`a5- -

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